CEFTRIAXONE clinical trials

The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis (other than for generalized peritonitis): a prospective, randomized, open-label, non-inferiority Phase III study.

This study is looking at whether giving antibiotics after surgery for a complicated appendix reduces new infections. It compares common antibiotics to see which works best for patients aged 18 and over, after keyhole surgery.

PYELOCOURT - 3-day intravenous antibiotic treatment versus 3-day intravenous followed by 7-day oral antibiotic treatment for acute pyelonephritis in children 1 month to 3 years old: a non-inferiority open randomized multicentric clinical trial

This study looks at how best to treat kidney infections in children aged 1 month to 3 years. It compares a 3-day IV antibiotic with a 3-day IV followed by a 7-day oral antibiotic. The main goal is to see which treatment best prevents the infection from coming back.

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.

Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.

This study looks at how well antibiotics work in very sick patients. Researchers want to make sure these important medicines reach the right levels in the body to fight serious infections effectively and safely. It's about getting the dose just right.

Prospective Multicenter Randomized Non-Inferiority Study Comparing 7 Days Versus 14 Days of Antibiotic Treatment for Graft Pyelonephritis in Kidney Transplant Recipients (KTI)

This study compares different antibiotic treatment lengths (7 days vs. 14 days) for kidney transplant patients who get a kidney infection. Researchers want to see if a shorter treatment works just as well to prevent serious problems.

ANTIPROM - Comparison of two prophylactic antibiotic regimens in case of preterm prelabor rupture of membranes before 34 weeks of gestation: a randomized controlled trial

This study looks at two different combinations of antibiotics given to pregnant women whose waters have broken early (before 34 weeks). The aim is to find the best way to protect both the mother and baby from serious problems and infections.

Efficacy of Temocillin compared to standard of care in the Treatment of Neisseria gonorrhoeae Infections: A Multicenter Randomized Controlled Non-Inferiority Trial (TEMtoGo).

This study is testing a new antibiotic called Temocillin to see if it's as good as the usual treatment for gonorrhoea. Researchers want to find out if it can successfully clear the infection, checking at different body sites, and if it has any side effects.

COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial