comprimé pelliculé clinical trials
13 indexed studies · 0 currently recruiting
- AuthorisedTherapeutic confirmatory (Phase III)
Effectiveness of a preventive strategy for cytomegalovirus infection guided differently from a universal prophylactic strategy in kidney transplant patients - CYTOPREV
This study compares different ways to prevent cytomegalovirus (CMV) infection after a kidney transplant. It tests a specific medicine, VALGANCICLOVIR VIATRIS, to see how well it works and if it's better than standard prevention to keep patients healthy.
For: CMVFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Pilot study of safety and efficacy of nicotinamide (vitamin B3) in OPA1 Dominant Optic Atrophy - NICOPA1-TOL
This study is looking at a vitamin B3 treatment for Dominant Optic Atrophy. We want to see if it's safe and if it helps improve vision. We'll check for any side effects and see if people's eyesight gets better over time. It's a key stage in testing this new treatment.
For: Dominant Optic AtrophyFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
IBCSG 67-22 PREcoopERA: A Window-of-Opportunity trial of giredestrant +/- triptorelin vs. anastrozole + triptorelin in premenopausal patients with ER-positive/HER2-negative early breast cancer.
This study looks at new ways to treat early breast cancer in women before menopause. It compares different hormone treatments to see which best slows down cancer cell growth, using medicines like giredestrant, triptorelin, and anastrozole. The aim is to find more effective options for this type of breast cancer.
For: ER-positive/HER2-negative early breast cancerSpain · Germany · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized crossover clinical trial regarding the blockage of the mineralocorticoid receptor using Eplerenone on the evolution of arterial stiffness in kidney patients one year after transplant: EVATRAN (The effect of Eplerenone on the evolution of Vasculopathy in renal transplant patients).
This study looks at how a drug called eplerenone affects the stiffness of blood vessels in kidney transplant patients. Researchers want to see if it can improve heart and blood vessel health a year after a kidney transplant.
For: kidney transplantationFrance - AuthorisedTherapeutic exploratory (Phase II)
VASCULAR AND RENAL IMPACT OF ENDOTHELIN-1 RECEPTOR BLOCKADE IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION - ENDOTHELIN-2
This study is looking at a new way to treat high blood pressure that isn't controlled by usual medicines. It will test a drug called bosentan to see if it helps blood vessels relax and improves blood flow over 8 weeks.
For: Uncontrolled arterial hypertensionFrance - AuthorisedTherapeutic confirmatory (Phase III)
Comparison of azathioprine to methotrexate in combination therapy with adalimumab in Crohn’s Disease: an open-label randomized controlled trial
This study looks at how well two different medicines, azathioprine and methotrexate, work when given with another medicine called adalimumab. It’s for adults with Crohn’s disease and aims to see which combination helps heal the gut lining better.
For: Crohn’s DiseaseFrance - AuthorisedTherapeutic confirmatory (Phase III)
Efficacy of domperidone (a prokinetic agent) on time in range in digestively asymptomatic type I diabetic patients with delayed gastric emptying
This study looks at whether a drug called domperidone can help people with Type 1 diabetes better manage their blood sugar if they also have slow stomach emptying. Researchers want to see if it increases the time their blood sugar stays in a healthy range.
For: Type 1 Diabetic patientsFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
E-merge - Evaluation of MEpolizumab-based regimen Compared to Conventional Therapeutic Strategy For Remission Induction In Patients With Eosinophilic Granulomatosis With Polyangiitis. Prospective, randomized, controlled, double-blind study
This study is testing a new way to treat EGPA, a rare condition causing inflammation. It compares a new drug called mepolizumab to standard treatments to see if it can help patients reduce their steroid dose and avoid flare-ups.
For: Eosinophilic granulomatosis with polyangiitis (EGPA) · formerly called Churg-Strauss syndromeFrance - AuthorisedTherapeutic confirmatory (Phase III)
A randomized phase III trial of short-course versus long-course pre-operative chemotherapy with mFOLFIRINOX or PAXG regimen for stage I-III pancreatic ductal adenocarcinoma (PDAC)
This study looks at different ways to give chemotherapy before surgery for pancreatic cancer. We want to see if a shorter or longer course of treatment works better in helping people live longer and preventing the cancer from growing.
For: pancreatic ductal adenocarcinomaItaly - AuthorisedTherapeutic use (Phase IV)
Pharmacokinetic study of the use of Nefopam 30 mg tablet in patients suffering from acute pain in rheumatology - NEFOPAIN kinetics
This study looks at how a pain medication called Nefopam works in people with sudden joint and muscle pain in hospitals. Researchers are checking how the body handles the medicine, seeing if the tablet and injection versions are similar, and aiming to find the best dose.
For: Hospitalized patient with acute rheumatological pain · requiring nefopam if necessaryFrance - AuthorisedTherapeutic confirmatory (Phase III)
ANTIBIOBONTA - Assessment of the interest of a peri-operative antibiotic strategy applied to patients with asymptomatic bacteriuria undergoing intra-vesical botulinum toxin A injections
This study looks at whether antibiotics before and after bladder botulinum toxin A injections can prevent urine infections. It's for adults with bladder problems from multiple sclerosis or spinal cord injury, who also have bacteria in their urine without symptoms.
For: Patients (male or female) ≥18 years old with Detrusor overactivity (DO) in multiple sclerosis (MS) or spinal cord injured (SCI).France - AuthorisedTherapeutic exploratory (Phase II)
SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells: a multicentre, single-arm, open-label phase II trial
This study is looking at a new way to treat severe eye burns caused by chemicals. It uses special cells from donors, called mesenchymal stem cells, injected near the eye. Doctors want to see if this treatment can stop the eye from developing a hole in its surface.
For: Patient with severe eye chemical burnsFrance - AuthorisedTherapeutic exploratory (Phase II)
Pilot study of the efficacy of nicotinamide (vitamin B3) in Leber's hereditary optic neuropathy - NICOLHON
This study looks at whether vitamin B3 (nicotinamide) can help improve vision in people with Leber's Hereditary Optic Neuropathy (LHON). Researchers will check vision changes over a year to see if the vitamin makes a difference for this eye condition.
For: Leber's Hereditary Optic NeuropathyFrance