comprimé sécable clinical trials

Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis (JAKUVEITE)

This study is looking at a new tablet treatment called baricitinib (Olumiant) for a type of eye inflammation called uveitis. Researchers want to see if it can help improve symptoms and reduce the need for other medications over six months.

A randomized non-inferiority clinical trial of doxycycline vs BPG for early syphilis

This study compares two treatments, doxycycline and BPG, for early syphilis. Researchers want to see if doxycycline works just as well as BPG. They will check how well the treatments reduce the infection over 6 months.

COURAGE - Corticosteroid in acute urticaria in emergency department

This study is looking at whether a steroid medication (like Prednisolone) helps adults who come to A&E with sudden, itchy skin rashes called urticaria (hives). They want to see if the steroid reduces the rash better than a dummy pill after 7 days.

SEM-CORTICO.Severe erythema multiform: A randomized controlled trial com-paring a short systemic corticosteroids regimen to placebo in the acute established phase.

This study looks into treating severe erythema multiforme, a serious skin condition, with a short course of steroid tablets like prednisolone. They want to see if this helps patients get better faster compared to a dummy treatment, focusing on pain control and eating.

ANA4CKD - Randomized multicenter double-blind controlled trial comparing anakinra to prednisone for gout flare in patients with chronic kidney disease stage 4-5 or kidney transplantation

This study is looking at two treatments for painful gout attacks in people with kidney disease or a kidney transplant: anakinra and prednisone. Researchers want to see which one works better and causes fewer side effects by measuring pain levels and other health changes.

SPironolactONe for the maintenance of Sinus Rhythm in hypertensive patients with atrial fibrillation and preserved left ventricular ejection fraction: a Prospective Randomized Open Blinded End-point (PROBE) multicenter study (SPONSoR study).

This study looks at whether a medicine called spironolactone can help people with high blood pressure and an irregular heartbeat (atrial fibrillation) stay in a normal heart rhythm. It checks how well spironolactone works over 12 months in preventing their irregular heartbeat from coming back.

RANDOMIZED, CONTROLLED, OPEN TRIAL OF TWO STANDARDIZED DECLINE SCHEMES, FAST (NORTH AMERICAN) AND SLOW (EUROPEAN) RESPECTIVELY, OF CORTISONE IN GIANT CELL ARTERITIS

This study compares two ways of slowly reducing steroid medication for Giant Cell Arteritis (GCA), a condition causing inflammation of blood vessels. It looks at whether a faster or slower reduction helps patients stay well without their symptoms returning, known as remission.

French prospective open label phase II randomized non-comparative study of SC tocilizumab associated with IV pulse steroid versus IV pulse steroid alone for the treatment of acute anterior ischemic optic neuropathy associated with giant cell arteritis. (TOCIAION)

This study looks at a new way to treat sudden vision loss from a condition called giant cell arteritis (GCA). It compares standard treatment with a new drug, tocilizumab, to see if the new drug can help improve eyesight more effectively.

Efficiency of a composite personalised care on functional outcome in early psychosis: A Prospective Randomised Controlled Trial

This study is looking at how well a special personalised care package, which includes certain supplements like vitamins and omega-3, works for young people who are at very high risk of developing psychosis or who have recently experienced their first episode. It aims to see if this care can help improve their daily lives.

COTAM - Use of glucocorticoids therapy in acute myocarditis with severe left ventricular dysfunction: a multicenter randomized controlled trial

This study looks at whether a steroid medicine called methylprednisolone can help people with severe acute myocarditis, a heart condition. Researchers will compare it to a dummy medicine to see if it improves heart function and prevents serious heart problems.

Efficacy of Ursodeoxycholic Acid versus Corticosteroids for the Treatment of Cholestatic Hepatitis Secondary to Immunotherapy: A Multicenter, Controlled, Randomized, Open Trial

This study compares two treatments, ursodeoxycholic acid and steroids, for liver inflammation caused by cancer immunotherapy. It wants to see which treatment helps liver function improve by at least 25% within 21 days.

Evaluation of the efficacy of corticosteroids in septic arthritis in adults: Randomized double-blind controlled trial [CORSAR]

This study, called CORSAR, is looking at whether a steroid medicine called prednisone can help adults with septic arthritis. Researchers want to see if it improves how well people can use their affected joints over 24 weeks.

Multicentre study evaluating the efficacy of a 7-day course of doxycycline for the treatment of asymptomatic anal lymphogranuloma venereum SHORT-LGV

This study is testing if a 7-day course of doxycycline can cure a specific type of asymptomatic anal LGV infection in men. Doctors will check if the infection clears up after treatment.

Comparative Bioavailability and Bioequivalence of Oxazepam 50 mg Orodispersible Tablets (Test) Versus Seresta® 50 mg Tablets (Reference): A Single-Dose, Open-Label, Randomized, Two-Sequence, Two-Treatment, Two-Period Crossover Study in Healthy Subjects