- Ongoing, recruitingTherapeutic confirmatory (Phase III)
Tisagenlecleucel versus standard of care in adult patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma: A randomized, open label, phase III trial (BELINDA)
This study compares a new cell therapy (Tisagenlecleucel) with standard treatments for adults with an aggressive type of lymphoma that has come back or not responded to previous therapy. Researchers want to see which treatment is better at stopping the cancer from growing.
For: Adult patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphomaNetherlands · Spain · Norway - RecruitingPHASE1, PHASE2
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
This study looks at new treatments for children and young adults with specific types of blood cancer that have come back or not responded to previous treatment. It tests a combination of medicines to see if they are safe and work well for those whose cancer has certain genetic changes.
For: Acute Lymphoblastic Leukemia, in Relapse · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentAustria · Belgium · Denmark - Active not recruitingPHASE1
A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies
This study is testing a new drug called Bleximenib alongside standard treatments for acute myeloid leukaemia (AML). It aims to find the safest and most effective dose of Bleximenib when given with other AML medicines, and to understand its side effects.
For: Leukemia, Myeloid, AcuteUnited States · Australia · Canada - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase-I/II trial for relapsed or refractory AML patients combining cytarabine and mitoxantrone with venetoclax (TUD-RELAX1-070)
This study is for adults with a type of blood cancer called AML that has come back or not responded to usual treatments. It's testing a new combination of medicines to see if it's safe and helps more people. It combines standard chemotherapy drugs with a newer drug called venetoclax.
Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
Rituximab, bendamustine and cytarabine followed by venetoclax (V-RBAC) in high-risk elderly patients with mantle cell lymphoma (MCL)
This study is looking at a new treatment combination — rituximab, bendamustine, cytarabine, and venetoclax (V-RBAC) — for older patients with a specific type of blood cancer called mantle cell lymphoma. It aims to see how well this new treatment stops the cancer from growing for at least two years.
For: Mantle Cell LymphomaItaly - Ongoing, recruitingTherapeutic exploratory (Phase II)
A PHASE I/II STUDY TO EVALUATE THE SAFETY AND EFFICACY OF MEBENDAZOLE IN COMBINATION WITH LOW-DOSE ARA-C IN ELDERLY PATIENTS WITH RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA (MAIL)
This study is looking at a new way to treat acute myeloid leukaemia (AML) in older patients where other treatments haven't worked or stopped working. It combines two medicines, mebendazole and Ara-C, to see if they are safe and effective together.
For: relapsed/refractory acute myeloid leukemiaGermany - Active not recruitingPHASE2, PHASE3
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT
This study looks at new treatments for adults with acute myeloid leukaemia (AML) and high-risk myelodysplastic syndrome (MDS) who are having a stem cell transplant. It aims to improve transplant success and reduce relapse.
For: Acute Myeloid Leukaemia · High-risk Myelodysplastic SyndromeUnited Kingdom - RecruitingPHASE1, PHASE2
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
This study is for children and young adults aged 1-21 with specific types of aggressive blood cancers that have come back or not responded to treatment. It tests new drug combinations to see if they're safe and work well for those with certain genetic changes in their cancer.
For: Acute Lymphoblastic Leukemia · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentAustria · Belgium · Denmark - RecruitingPHASE1, PHASE2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This study is for children and young people with cancer that hasn't responded to usual treatments. It tests new medicines that target specific changes in cancer cells, aiming to find the right dose and see if they help. The goal is to find better ways to treat childhood cancer.
For: Pediatric CancerDenmark · France · Italy - RecruitingPHASE1, PHASE2
HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies
This study looks at new drug combinations for children and young adults with blood cancers (leukaemia and lymphoma) that have come back or not responded to treatment. It focuses on cancers with specific genetic changes, hoping to find safer and more effective ways to help them.
For: Acute Lymphoblastic Leukemia, in Relapse · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentAustria · Belgium · Denmark - RecruitingPHASE3
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia
This study looks at new ways to treat children with a type of blood cancer called Acute Myeloid Leukaemia (AML). It compares different chemotherapy drugs, including a drug called gemtuzumab ozogamicin, and different types of stem cell transplants to find the most effective and safest treatments for young patients.
For: Acute Myeloid LeukaemiaAustralia · France · Ireland - AuthorisedTherapeutic exploratory (Phase II)
Revumenib Treatment in Combination with FLA Chemotherapy in Paediatric Refractory/Relapsed KMT2A-r, NUP98-r or NPM1-mut Acute Myeloid Leukemia (AML)
This study is testing a new drug called Revumenib with standard chemotherapy for children and young people with a type of blood cancer called Acute Myeloid Leukaemia (AML). It's for those whose cancer has returned after treatment or hasn't responded to initial therapy.
For: Acute Myeloid LeukemiaDenmark · Italy · Czechia