Treatment

Dapagliflozin placebo clinical trials

2 indexed studies · 0 currently recruiting

Ongoing, recruitingTherapeutic exploratory (Phase II)
A Multicentre, Randomised, Double-blind, Placebo-controlled, Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Combination Compared to Zibotentan Monotherapy as well as Zibotentan/Dapagliflozin and Zibotentan Monotherapy Compared to Placebo in Participants with Cirrhosis
This study is looking at how safe new drug combinations (Zibotentan with Dapagliflozin, or Zibotentan on its own) are for people with liver scarring (cirrhosis). Researchers want to see if these treatments help manage fluid build-up in the body, compared to a dummy pill.
For: Cirrhosis of the liver is a condition in which the liver is scarred and damaged
Belgium · Slovakia · Czechia
Ongoing, recruitingTherapeutic exploratory (Phase II)
A Two Part Phase IIa/b Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel Group Dose ranging Study to Assess Efficacy, Safety, and Tolerability of the Combination of Zibotentan and Dapagliflozin, and Dapagliflozin Monotherapy Versus Placebo in Participants with Cirrhosis with Features of Portal Hypertension
This study looks at new ways to treat liver scarring (cirrhosis) that causes high pressure in the liver. We are testing a combination of two medicines, Zibotentan and Dapagliflozin, against Dapagliflozin alone or a dummy pill, to see if they can lower this pressure and are safe.
For: Liver cirrhosis with features of portal hypertension.
Spain · Germany · Netherlands