- Ongoing, recruitingTherapeutic use (Phase IV)
A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults
This study is looking at whether a high-dose flu vaccine works better than the standard flu vaccine for older adults. It aims to see if the high-dose vaccine helps prevent hospital stays due to flu or pneumonia.
For: Prevention of influenza infection in older adultsDenmark - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, randomized, dose-finding/dose-confirmation study to evaluate the reactogenicity, safety and immunogenicity of mRNA-based multivalent seasonal influenza vaccine candidates administered in healthy younger and older adults
This study is testing new mRNA flu vaccines in healthy adults. Researchers want to see how safe they are, if they cause side effects, and how well they help your body fight the flu, compared to existing flu jabs. It's a key first step for new vaccine development.
For: Healthy volunteers (prevention of influenza infection)Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized Double-blind Controlled Study to Evaluate the Immunogenicity, Safety, and Reactogenicity of ExPEC9V and High-dose Quadrivalent Influenza Vaccine, With and Without Co-administration, in Adults Aged 65 Years or Older
This study looks at a new vaccine to prevent serious E. coli infections and a strong flu vaccine in people aged 65 and over. Researchers want to see how well they work, how safe they are, and if they can be given together.
For: Prevention of invasive extraintestinal pathogenic Escherichia coli (ExPEC) diseaseBelgium · Poland