- AuthorisedTherapeutic use (Phase IV)
Optimizing the antibiotic treatment of uncomplicated acute appendicitis: a prospective randomized multicenter study
This study looks at different antibiotic treatments for mild appendicitis. Researchers want to see which antibiotics work best to avoid surgery and prevent the appendicitis from returning for at least a year. It's for adults aged 18 and over.
For: Uncomplicated acute appendicitisFinland - AuthorisedTherapeutic use (Phase IV)
Acute appendicitis and microbiota – etiology and effects of the antimicrobial treatment - MAPPAC
This study looks at how antibiotics for appendicitis affect the helpful germs (microbiota) in your gut. It aims to see if certain gut germs are linked to more serious appendicitis and how different antibiotics change them.
For: Uncomplicated acute appendicitis · Complicated acute appendicitisFinland - AuthorisedTherapeutic use (Phase IV)
Antibiotic therapy vs. placebo in the treatment of acute uncomplicated appendicitis: a prospective randomized double-blind placebo-controlled trial - APPAC III
This study, called APPAC III, is looking at whether antibiotics can successfully treat acute appendicitis without surgery. We're comparing antibiotics to a dummy treatment to see if patients get better and avoid an operation. It's for adults with uncomplicated appendicitis.
For: Uncomplicated acute appendicitisFinland - AuthorisedTherapeutic use (Phase IV)
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
This study looks at how well antibiotics work in very sick patients. Researchers want to make sure these important medicines reach the right levels in the body to fight serious infections effectively and safely. It's about getting the dose just right.
For: Serious infections in critically ill patients treated with antibioticsFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial
For: Intensive Care · Ventilator-associated PneumoniaFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Temocillin versus meropenem for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (ASTARTÉ):randomised, pragmatic trial
For: Infections due to EnterobacteriaceaeSpain