- Active not recruitingPHASE1
A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer
This study looks at new ways to treat head and neck cancer. It combines different medicines that help your immune system fight cancer and stop tumours from growing. It's for people whose previous treatments weren't successful or who don't have standard options.
For: Head and Neck Squamous Cell Carcinoma (HNSCC)United States · France · Japan - Ongoing, recruitingTherapeutic exploratory (Phase II)
EMPIRE : Targeting MDM2 and PD1 in tumors with tertiary lymphoid structures
This study is looking into new ways to treat advanced solid cancers. It's testing a combination of medicines (BI 907828 and Ezabenlimab) to see if they can help control the cancer's growth in adult patients. Researchers want to understand how well these drugs work.
For: Adult patients with locally advanced/metastatic solid tumorsFrance - AuthorisedTherapeutic exploratory (Phase II)
A phase II trial evaluating treatment intensification with Ezabenlimab in patients with PD-L1–expressing, locally advanced head and neck squamous cell carcinoma (LA-HNSCC) with minimal residual disease (MRD) as detected by circulating tumor DNA (ctDNA) after curative-intent chemoradiation
This study is looking at a new treatment called Ezabenlimab for a type of head and neck cancer. It focuses on patients who have small traces of cancer left after their first treatment, to see if adding Ezabenlimab can prevent the cancer from coming back.
For: Locally advanced head and neck squamous cell carcinoma (LA-HNSCC)Belgium - RecruitingPHASE1
A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
This study looks at new treatments, BI 1703880 and Ezabenlimab, for different advanced cancers in adults when other treatments haven't worked. Doctors want to find a safe dose and see if these new drugs help the body fight cancer.
For: Solid TumorsUnited States · Japan · Spain