- Ongoing, recruitingTherapeutic use (Phase IV)
Optimization of the management of drepanocytosis patients treated with hydroxyurea: Interest of the pharmacological therapeutic follow-up
This study is looking at how to give the medicine hydroxyurea more effectively to people with sickle cell disease. It wants to find the best dose to help patients and reduce side effects, making their treatment work better in the long run.
For: DrepanocytosisFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
TSPO ligands in the treatment of depression: proof-of-concept of efficacy and underlying mechanisms of action
This study is testing a new capsule treatment for different types of depression. Researchers want to see if it helps improve mood and understand how it works in the body. It's an early-stage study open to adults aged 18 and over.
For: Unipolar/bipolar depressive disorderGermany - Ongoing, recruitingTherapeutic use (Phase IV)
Short-term effectiveness of Gabapentin versus Placebo in acute Lumbosacral Radiculalgia by herniation disc: a prospective, multicentric, randomized, controlled, double-blind study (GRADE)
This study looks at whether gabapentin helps reduce nerve pain in the lower back (lumbosacral radiculalgia) caused by a slipped disc, compared to a dummy pill (placebo). Researchers are checking pain levels after a short time.
For: lumbosacral radiculalgiaFrance - AuthorisedTherapeutic use (Phase IV)
PTX3 genetically stratified randomized double-blinded allocation event-driven clinical trial for antifungal prophylaxis in patients with acute myeloid leukemia
This study looks at different medicines to prevent fungal infections in people with a type of blood cancer called acute myeloid leukaemia. It compares how well these medicines work over 6 months to keep people healthy.
For: Antifungal prophylaxis in patients with acute myeloid leukemiaBelgium · France - AuthorisedTherapeutic use (Phase IV)
Efficiency of a composite personalised care on functional outcome in early psychosis: A Prospective Randomised Controlled Trial
This study is looking at how well a special personalised care package, which includes certain supplements like vitamins and omega-3, works for young people who are at very high risk of developing psychosis or who have recently experienced their first episode. It aims to see if this care can help improve their daily lives.
For: Ultra High Risk of psychosis and first episode psychosisFrance - AuthorisedTherapeutic confirmatory (Phase III)
RIFAMAB : Rifabutin versus rifampicin for treatment of staphylococcal prosthetic joint infection treated with debridement, antibiotics and implant retention (DAIR strategy): a multicenter randomized, open-label, non-inferiority trial
This study compares two antibiotics, rifabutin and rifampicin, for treating joint infections caused by bacteria after surgery. It looks at how well they work to prevent further problems after a procedure called DAIR, which cleans the infection without removing the whole joint.
For: Adult with an staphylococcal prosthetic joint infection treated with debridement · antibiotics and implant retention (DAIR strategy)France - AuthorisedTherapeutic confirmatory (Phase III)
Rifampin-free regimen versus rifampin-containing regimen in the treatment of staphylococcal prosthetic valve endocarditis: a multicenter randomized controlled non-inferiority study (RIFREE)
This study compares two ways to treat a serious heart infection called staphylococcal endocarditis, which affects artificial heart valves. It looks at whether treatment without a medicine called rifampin is as good as treatment with it, focusing on patient survival after six months.
For: staphylococcal endocarditisFrance - AuthorisedTherapeutic exploratory (Phase II)
SYMBOL CLINICAL : Treatment of severe ocular chemical burns by subconjunctival injection of allogeneic mesenchymal stem cells: a multicentre, single-arm, open-label phase II trial
This study is looking at a new way to treat severe eye burns caused by chemicals. It uses special cells from donors, called mesenchymal stem cells, injected near the eye. Doctors want to see if this treatment can stop the eye from developing a hole in its surface.
For: Patient with severe eye chemical burnsFrance