Treatment

GEMCITABINE HYDROCHLORIDE clinical trials

3 indexed studies · 0 currently recruiting

Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination With Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARTISTRY-7)
This study is testing a new combination treatment for advanced ovarian, fallopian tube, or peritoneal cancers that haven't responded to previous chemotherapy. It compares a new drug, nemvaleukin alfa, with an existing cancer drug, pembrolizumab, against standard chemotherapy treatments to see if it helps people live longer.
For: Platinum-Resistant Epithelial Ovarian · Fallopian Tube · or Primary Peritoneal Cancer
Italy · Norway · Spain
Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2 Study of Preoperative Gemcitabine Plus Cisplatin with Durvalumab (MEDI4736) and Tremelimumab in intrahepatic cholangiocarcinoma (NeoTreme)
This study is testing a new combination of medicines before surgery for a rare type of liver cancer called intrahepatic cholangiocarcinoma. It aims to see if these medicines can help more patients have successful surgery by making the tumour smaller or easier to remove.
For: intrahepatic cholangiocarcinoma
Germany
Ongoing, recruitingTherapeutic confirmatory (Phase III)
Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)
This study looks at extra medicine (chemotherapy) after surgery for certain bile duct or gallbladder cancers. It compares a standard treatment to a new combination, hoping to stop the cancer from coming back and help people live longer and better.
For: Patients after curative intent resection of cholangiocarcinoma (intrahepatic · hilar or distal) or muscle invasive gallbladder carcinoma (without evidence of metastatic disease).
Austria · Germany · Italy

A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination With Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARTISTRY-7)

Phase 2 Study of Preoperative Gemcitabine Plus Cisplatin with Durvalumab (MEDI4736) and Tremelimumab in intrahepatic cholangiocarcinoma (NeoTreme)

Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)