- Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(siplizumab) Compared to Anti-Thymocyte Globulin (rATG), as Induction Therapy in de novo Renal Transplant Recipients
This study looks at a new medicine called TCD601 (siplizumab) for people who have recently had a kidney transplant. It compares TCD601 to a standard treatment to see if it's safe and how well it helps prevent the body from rejecting the new kidney.
For: Renal TransplantationSweden · Spain · Austria - Ongoing, recruitingTherapeutic exploratory (Phase II)
TSPO ligands in the treatment of depression: proof-of-concept of efficacy and underlying mechanisms of action
This study is testing a new capsule treatment for different types of depression. Researchers want to see if it helps improve mood and understand how it works in the body. It's an early-stage study open to adults aged 18 and over.
For: Unipolar/bipolar depressive disorderGermany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A 6-week, International, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of the Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 years of age) with Schizophrenia
This study is looking at a medicine called cariprazine for young people aged 13 to 17 who have schizophrenia. It compares different doses of cariprazine with a dummy pill (placebo) over 6 weeks to see if it helps with symptoms and is safe.
For: Adolescent Patients (13 to 17 years of age) with SchizophreniaRomania · Bulgaria - Ongoing, recruitingTherapeutic exploratory (Phase II)
Precision therapy versus standard therapy in Acute Myeloid Leukaemia and Myelodysplastic syndrome in elderly (PALM) – a phase II randomized clinical trial
This study looks at new, personalised treatments for older people with certain blood cancers like Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS). It compares these 'precision' treatments with standard care to see which works best and offers the best value for money in improving quality of life.
For: Chronic myelomonocyte leukemia · Myelodysplastic syndrome · Acute myeloid leukemiaNorway - Ongoing, recruitingTherapeutic use (Phase IV)
The OPTIMIzE study;OPen label multicenter randomized Trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients.
This study looks at new ways to give medicines after a kidney transplant to elderly patients. It compares standard treatment with a different combination of drugs to see which works best for protecting the new kidney and keeping patients healthy.
For: kidney transplantNetherlands · Belgium - AuthorisedPhase III and phase IV (Integrated)
Ultrasound-guided Radiofrequency Ablation versus radioactive Iodine as treatment for Hyperthyroidism caused by Solitary Autonomous Thyroid Nodules (RABITO study)
This study compares two treatments for an overactive thyroid lump: a new ultrasound-guided heat treatment (radiofrequency ablation) and radioactive iodine. Researchers are checking how well they work, if they cause an underactive thyroid, and their overall safety for adults in the UK.
For: Hyperactive thyroid nodulesNetherlands - AuthorisedTherapeutic exploratory (Phase II)
TARGET-EBV in MS: A prospective randomized controlled parallel group phase 2b double blinded study to investigate if targeting Epstein Barr Virus with Tenofovir Alafenamide Fumarate compared to placebo as add-on treatment to anti-CD20 therapy reduces neuronal damage in multiple sclerosis
This study looks into whether a drug called Tenofovir Alafenamide, given alongside a standard MS treatment, can help reduce nerve damage in people with multiple sclerosis by targeting the Epstein-Barr virus. It compares the drug to a dummy pill.
For: multiple sclerosisNorway