- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
For: Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban · rivaroxaban · or edoxaban) who require urgent surgery or procedureFrance · Portugal · Spain - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2 / Phase 3, Multicenter, Randomized, Multiple-Dose, Double-Blind, Placebo-Controlled Adaptive Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents with Sickle Cell Disease during Vaso-Occlusive Crisis
This study is looking at a new medicine called CSL889 for people having a sickle cell pain crisis. We want to see if it's safe, helps reduce pain faster, and how the body uses it compared to a sham treatment.
For: Sickle cell disease vaso-occlusive crisisSpain · Italy · Greece