- RecruitingPHASE3
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This study is testing a new medicine, Opevesostat, for men with prostate cancer that has spread and is resistant to hormone treatment. We want to see if Opevesostat helps men live longer compared to standard hormone therapies, especially after they've had other treatments.
For: Prostate Cancer MetastaticUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
This study compares a new medicine, opevesostat, with existing treatments like abiraterone or enzalutamide for prostate cancer that has spread and is no longer responding well to standard hormone therapy. It aims to see if opevesostat is safer and more effective at stopping cancer growth.
For: Metastatic Castration-resistant Prostate Cancer (mCRPC) · Prostatic NeoplasmsUnited States · Australia · Brazil - RecruitingTherapeutic confirmatory (Phase III)
I4V-MC-JAIP: A Phase 3, Multicenter, Randomized, Double blind, Placebo controlled, Parallel group, Outpatient Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Baricitinib in Pediatric Patients with Moderate-to-Severe Atopic Dermatitis
This study is looking at a new medicine called Baricitinib for children and teenagers with moderate to severe eczema. It wants to see if the medicine is safe and effective in helping their skin get better, compared to a dummy pill.
For: Atopic DermatitisHungary · Czechia · Poland - Active not recruitingPHASE3
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
This study looks at new ways to treat childhood acute lymphoblastic leukemia (ALL). It explores how to choose the right treatment strength for each child and tests a new way to give a common chemotherapy drug called pegaspargase.
For: Acute Lymphoblastic Leukemia, PediatricUnited States · Canada - RecruitingPHASE3
Comparison of Topical Treatment for Inflammatory Secretions of the Conjonctiva (Patients With Ocular Prostheses)
This study looks at different eye drops for people with artificial eyes who have discomfort or discharge. It compares two common medications, Hydrocortisone and Dexamethasone, to see which works best and if they can ease irritation.
For: Ocular Inflammation · Ocular ProsthesesFrance - Active not recruiting
Effect of Early Hydrocortisone on Risk of Gastrointestinal Perforations in Extremely Preterm Infants
This study looks at whether a common treatment for very premature babies (hydrocortisone) might increase the risk of a rare gut problem called intestinal perforation. Researchers are using existing hospital records to find out if there's a link, helping to make treatments safer for tiny infants.
For: Intestinal PerforationUnited Kingdom