- Active not recruiting
Effect of Early Hydrocortisone on Risk of Gastrointestinal Perforations in Extremely Preterm Infants
This study looks at whether a common treatment for very premature babies (hydrocortisone) might increase the risk of a rare gut problem called intestinal perforation. Researchers are using existing hospital records to find out if there's a link, helping to make treatments safer for tiny infants.
For: Intestinal PerforationUnited Kingdom - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of ANB032 in the Treatment of Subjects with Moderate to Severe Atopic Dermatitis
This study is testing a new medicine, ANB032, for people with moderate to severe eczema (atopic dermatitis). We want to see if it makes skin better and if it's safe to use, compared to a dummy treatment.
For: Atopic DermatitisPoland · Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I4V-MC-JAIP: A Phase 3, Multicenter, Randomized, Double blind, Placebo controlled, Parallel group, Outpatient Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Baricitinib in Pediatric Patients with Moderate-to-Severe Atopic Dermatitis
This study is looking at a new medicine called Baricitinib for children and teenagers with moderate to severe eczema. It wants to see if the medicine is safe and effective in helping their skin get better, compared to a dummy pill.
For: Atopic DermatitisHungary · Czechia · Poland - RecruitingPHASE3
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
This study compares a new medicine, opevesostat, with existing treatments like abiraterone or enzalutamide for prostate cancer that has spread and is no longer responding well to standard hormone therapy. It aims to see if opevesostat is safer and more effective at stopping cancer growth.
For: Metastatic Castration-resistant Prostate Cancer (mCRPC) · Prostatic NeoplasmsUnited States · Australia · Brazil - RecruitingPHASE3
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This study is testing a new medicine, Opevesostat, for men with prostate cancer that has spread and is resistant to hormone treatment. We want to see if Opevesostat helps men live longer compared to standard hormone therapies, especially after they've had other treatments.
For: Prostate Cancer MetastaticUnited States · Argentina · Australia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Reducing Supraphysiologic Glucocorticoid Use in Adult Subjects with Classic Congenital Adrenal Hyperplasia
This study is looking into a new medication called Tildacerfont for adults with a condition called classic congenital adrenal hyperplasia. It aims to see if Tildacerfont can help reduce the amount of steroid medicine (like hydrocortisone or prednisolone) people need to take.
For: Classic Congenital Adrenal HyperplasiaSweden · Netherlands · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Adult Subjects with Classic Congenital Adrenal Hyperplasia
This study is testing a new medicine, Tildacerfont, for adults with a condition called Classic Congenital Adrenal Hyperplasia (CAH). Doctors want to see if it helps reduce certain hormone levels and if it's safe to use.
For: Classic Congenital Adrenal HyperplasiaSweden · Netherlands · Ireland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Week, Phase 2 Open-Label, Sequential Dose Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 Treatment in Participants with Congenital Adrenal Hyperplasia
This study is looking at a new treatment called CRN04894 for people with Congenital Adrenal Hyperplasia (CAH). It will check if the treatment is safe, how well it works, and how the body handles it. This is an early-stage study.
For: CONGENITAL ADRENAL HYPERPLASIAGermany · Italy - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First in-Human, Consecutive-Cohort, Clinical Trial of BI 1910, a Monoclonal Antibody to Tumor Necrosis Factor Receptor 2 (TNFR2), as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
This study is testing a new drug, BI 1910, for people with advanced cancers. It will check how safe the drug is, what side effects it causes, and how much of it the body can handle, both on its own and when given with another cancer drug.
For: Advanced solid tumorsDenmark · Poland · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, ADAPTIVE PHASE III TRIAL TO INVESTIGATE EFFICACY AND SAFETY OF VILOBELIMAB IN THE TREATMENT OF ULCERATIVE PYODERMA GANGRENOSUM
This study is testing a new medicine called Gohibic for people with a skin condition called ulcerative pyoderma gangrenosum. It compares Gohibic to other treatments or a dummy medicine to see if it helps heal the ulcers and reduces pain, with the aim of finding better ways to treat this condition.
For: ulcerative pyoderma gangrenosumBelgium · Hungary · Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
For: Rheumatoid arthritisPoland - AuthorisedTherapeutic confirmatory (Phase III)
Prolonged corticosteroid therapy in scheduled cardiac surgery in intermediate/high-risk patients: a prospective multicenter randomized controlled double-blind placebo-controlled study
This study is looking at whether giving certain steroid medicines before and after heart surgery in people with higher risks helps prevent problems like kidney failure or lung issues. It aims to see if these medicines are safe and effective.
For: high /medium risk cardiac surgery · acute renal failureFrance - AuthorisedTherapeutic exploratory (Phase II)
PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial
This study is looking for better ways to treat sepsis in adults. It's testing several existing medicines to see if any work well for different types of sepsis. The main goals are to improve survival and help patients recover without needing machines to support their bodies.
For: SepsisFrance