Hydrokortison ”Orion” clinical trials

REPLACE - A multi-centre, randomised, double-blinded, placebo controlled 16-weeks study to compare the effect of hydrocortisone and placebo in patients with Giant Cell Arteritis (GCA)/ Polymyalgia Rheumatica (PMR) with patient-reported symptoms of adrenal insufficiency after cessation of glucocorticoid treatment.

This study looks at treating symptoms of adrenal insufficiency in people with Giant Cell Arteritis or Polymyalgia Rheumatica after they stop steroid treatment. It compares a hydrocortisone tablet to a dummy tablet over 16 weeks to see if it helps patients feel better.