- Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase 2, multi-center, open-label, randomized study of oral asciminib added to imatinib versus continued imatinib versus switch to nilotinib in patients with CML-CP who have been previously treated with imatinib and have not achieved deep molecular response
This study looks at new treatments for a type of blood cancer called Chronic Myeloid Leukaemia (CML). It compares a new drug, asciminib (Scemblix), with existing treatments (imatinib or nilotinib) in people whose CML hasn't fully responded to imatinib yet. The main goal is to see which treatment helps more people achieve a very low level of cancer cells.
For: Chronic Myelogenous Leukemia in chronic phase (CML-CP) · previously treated with imatinib and have not achieved deep molecular responseFrance · Spain · Italy - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
For: Community-acquired Pneumonia, Influenza, COVID-19United States · Australia · Belgium - RecruitingPHASE3
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
This study, called ALLTogether, is for children and young adults aged 0-45 with acute lymphoblastic leukaemia (ALL). It aims to improve survival and reduce side effects by combining the best treatments from several countries and testing new approaches.
For: Leukemia, Acute LymphoblasticBelgium · Denmark · Estonia - RecruitingPHASE4
Asciminib Roll-over Study
This study is for people who have already been taking a medicine called asciminib (or similar drugs) in a Novartis study for a type of blood cancer called CML. It allows them to keep taking the medicine if their doctor thinks it's still helping them.
For: Chronic Myelogenous Leukemia · Leukemia, Myelogenous, Chronic, BCR-ABL PositiveUnited States · Argentina · Austria - Active not recruitingPHASE3
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
This study looks at a new medicine called asciminib for adults with a type of blood cancer called CML. Researchers want to see if it works better than other standard CML treatments. It's for people recently diagnosed who haven't had treatment yet.
For: Chronic Myeloid Leukemia (CML) Philadelphia Chromosome PositiveUnited States · Australia · Austria