- Ongoing, recruitingTherapeutic confirmatory (Phase III)
Prophylactic nimodipine treatment for hearing preservation after vestibular schwannoma surgery: a randomized multi-center phase III trial (AkNiPro2)
This study is testing if a drug called nimodipine can help protect hearing after surgery for a non-cancerous growth near the brain called a vestibular schwannoma (also known as an acoustic neuroma). Researchers want to see if the drug can stop hearing from getting worse after the operation.
For: Acoustic schwannomaGermany - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, adaptive, open-label, single ascending dose to multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-3745 in participants with glycogen storage disease type 1a (GSD1a), followed by an open-label extension
This study is testing a new medicine, mRNA-3745, for Glycogen Storage Disease Type 1a (GSD1a). It's looking at how safe it is, how well people tolerate it, and how it works in the body, starting with low doses and gradually increasing them.
For: Glycogen storage disease type 1a (GSD1a)Spain · Poland · Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Perioperative oral analgesia versus intravenous analgesia for knee arthroscopy, a randomized, double-blinded, non-inferiority trial. OVIKA-trial - S68618
This study, called OVIKA, is looking at the best way to manage pain after a common knee operation. Researchers are comparing pain relief given through an IV drip with pain relief given as tablets to see if tablets work just as well for knee pain.
For: Postoperative pain relief after knee arthroscopyBelgium - Ongoing, recruitingTherapeutic use (Phase IV)
Selän alueen poikkeava aktiivisuus servikaalisessa dystoniassa
This study looks at how abnormal muscle activity in the back is linked to cervical dystonia, a condition causing twisted neck positions. It compares different botulinum toxin injections (like Botox) to see how well they reduce muscle overactivity and improve symptoms.
For: Servikaalinen dystonia · jossa poikkeavaa lihasaktiivisuutta esiintyy kaulan alueen lihaksissa aiheuttaen tyypillisiä virheasentoja kuten pään kiertymistä · kallistumista ja vapinaa. Servikaalista dystoniaa hoidetaan ensisijaisesti paikallisesti botuliinitoksiinipistoksillaFinland