- Ongoing, recruitingTherapeutic use (Phase IV)
Duration of peripheral nerve blocks in opioid tolerant individuals - A volunteer blinded matched case-control study
This study looks at how long special pain-blocking injections work in people who regularly use strong painkillers. It compares a pain-numbing medicine to see if it lasts longer in these individuals after an operation.
For: Postoperative painDenmark - Ongoing, recruitingPhase III and phase IV (Integrated)
The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block. A randomized controlled trial
This study looks at how well a mix of two pain medications, lidocaine and ropivacaine, works for hand surgery. Researchers want to see if combining them makes the numbing effect last longer and start quicker for patients.
For: Patients undergoing hand surgery for antebrachial fractures or arthroplasty/alloplasty of a thumb base joint in the handDenmark - AuthorisedTherapeutic use (Phase IV)
Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomized clinical trial
This study looks at different pain medicines (methadone, fentanyl, and oxycodone) after heart surgery. It wants to find out which one best reduces pain and limits the amount of strong pain relief needed, aiming for fewer problems and a better recovery for patients.
For: Following heart surgery · patients experience poor postoperative pain control and a moderate/high opioid consumptions. This is correlated to adverese events and poor outcome.Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Comparison of cocaine, lidocaine/xylometazoline and saline for intranasal analgesia - A blinded triple crossover study
This study is comparing different medicines (cocaine, a mix of lidocaine and xylometazoline, and salt water) given inside the nose to help reduce discomfort during a medical procedure where a breathing tube is put through the nose. It's looking at how much pain people feel.
For: Nasotracheal intubationDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Strategies towards personalised treatment in Juvenile Idiopathic Arthritis (JIA): An open randomised multicentre blinded-assessor trial assessing the effectiveness of intraarticular glucocorticoid injections in JIA patients starting tumour necrosis factor inhibitor treatment. The MyJIA trial.
This study, called MyJIA, looks at how well a steroid injection into joints works for children with juvenile idiopathic arthritis (JIA) who are also starting a new medicine called a TNF inhibitor. It wants to see if this combined approach helps them stay well for longer.
For: Juvenile Idiopathic ArthritisNorway - Ongoing, recruitingTherapeutic use (Phase IV)
A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Quadrivalent Influenza Vaccine vs. Standard-Dose Quadrivalent Influenza Vaccine in Older Adults
This study is looking at whether a high-dose flu vaccine works better than the standard flu vaccine for older adults. It aims to see if the high-dose vaccine helps prevent hospital stays due to flu or pneumonia.
For: Prevention of influenza infection in older adultsDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
A blinded randomized study of neostigmine/glycopyrrolate 50 mikrogram/kg or sugammadex 2 mg/kg for reversal of neuromuscular blockade in elderly patients (≥ 75 years)
This study looks at how well two common medicines help older patients (over 75) wake up after keyhole surgery using a robot. We're checking which medicine helps them recover fastest and if they have any problems afterwards.
For: Anaesthesia to laparoscopic robotassisted surgeryDenmark - Ongoing, recruitingPhase III and phase IV (Integrated)
The effect of the Popliteal Plexus Block on the motor function of the leg - a randomized, controlled, blinded study in volunteers
This study looks at how a type of pain relief, called a popliteal plexus block, affects leg movement after knee surgery. Researchers want to see if different pain medications used in the block change how well people can move their ankles after the procedure.
For: Acute post surgical pain after knee surgeryDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Intraoperative clonidine for postoperative pain management in patients undergoing spine surgery: a prospective, randomized, blinded, placebo-controlled trial
This study looks at whether a drug called clonidine, given during spine surgery, can help reduce the amount of strong pain relief (opioids) people need right after their operation. It aims to make recovery more comfortable for patients with back problems.
For: Degenerative spine diseasesDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Effect of ultrasound guided lateral infraclavicular brachial plexus block with Lidocaine or Ropivacaine for closed reduction of distal radius fractures - A randomized controlled non-inferiority trial
This study looks at two types of numbing medicine (Lidocaine or Ropivacaine) used for reducing broken wrists. Researchers want to see if one is as good as the other in quickly numbing the area using ultrasound guidance, to help set the bone without surgery.
For: Distal radius fractures with need of acute closed reductionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A trial comparing the effect and safety of once weekly dosing of somapacitan with daily Norditropin® in children with growth hormone deficiency
This study is looking at a new way to give growth hormone treatment to children. Instead of daily injections, it's testing a weekly injection called Sogroya against the usual daily treatment, Norditropin. The main goal is to see if weekly Sogroya helps children grow as well as daily treatment.
For: Growth Hormone Deficiency in childrenGermany · Italy · Spain - Ongoing, recruitingTherapeutic use (Phase IV)
A blinded randomized study of ephedrine 0.15 mg/kg for reducing onset time of rocuronium 0.6 mg/kg in elderly patients (≥ 80 years)
This study is looking at whether a medicine called ephedrine can help a muscle relaxant called rocuronium work faster in elderly patients (80 years or older) undergoing planned surgery. We want to see if ephedrine helps patients get ready for surgery more quickly.
For: Elective surgeryDenmark