- AuthorisedTherapeutic use (Phase IV)
Acute appendicitis and microbiota – etiology and effects of the antimicrobial treatment - MAPPAC
This study looks at how antibiotics for appendicitis affect the helpful germs (microbiota) in your gut. It aims to see if certain gut germs are linked to more serious appendicitis and how different antibiotics change them.
For: Uncomplicated acute appendicitis · Complicated acute appendicitisFinland - AuthorisedTherapeutic use (Phase IV)
Antibiotic therapy vs. placebo in the treatment of acute uncomplicated appendicitis: a prospective randomized double-blind placebo-controlled trial - APPAC III
This study, called APPAC III, is looking at whether antibiotics can successfully treat acute appendicitis without surgery. We're comparing antibiotics to a dummy treatment to see if patients get better and avoid an operation. It's for adults with uncomplicated appendicitis.
For: Uncomplicated acute appendicitisFinland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial
This study is looking at whether a common antibiotic, co-trimoxazole, can be used to treat pneumonia in patients on a ventilator in intensive care. It compares it to standard treatments to see if it works just as well and is safe.
For: Intensive Care · Ventilator-associated PneumoniaFrance - AuthorisedTherapeutic use (Phase IV)
Evaluation of the clinical implementation of biofilm susceptibility to antibiotics using Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC) to guide the treatment of periprosthetic joint infections; a prospective randomized clinical trial
This study looks at how best to treat infections around artificial hip or knee joints. It compares standard test results with a new test to see if combining them helps doctors choose better antibiotics and leads to fewer repeat infections or surgeries.
For: Periprosthetic hip joint infection Periprosthetic knee joint infectionSweden - AuthorisedTherapeutic use (Phase IV)
AIR. ANTIBIOTIC THERAPY IN RESPIRATORY TRACT INFECTIONS A controlled randomized, open label, multicenter, non-inferiority trial evaluating an individualized antibiotic treatment duration based on patient clinical response, evaluated through connected devices, for suspected community acquired pneumonia in the community setting
This study, called AIR, is looking at the best way to use antibiotics for chest infections (pneumonia). It compares different lengths of antibiotic treatment to see which works best, aiming to reduce how many antibiotics patients need.
For: Community acquired pneumonia (CAP)France - AuthorisedTherapeutic use (Phase IV)
Optimizing the antibiotic treatment of uncomplicated acute appendicitis: a prospective randomized multicenter study
This study looks at different antibiotic treatments for mild appendicitis. Researchers want to see which antibiotics work best to avoid surgery and prevent the appendicitis from returning for at least a year. It's for adults aged 18 and over.
For: Uncomplicated acute appendicitisFinland - AuthorisedTherapeutic confirmatory (Phase III)
The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis (other than for generalized peritonitis): a prospective, randomized, open-label, non-inferiority Phase III study.
This study is looking at whether giving antibiotics after surgery for a complicated appendix reduces new infections. It compares common antibiotics to see which works best for patients aged 18 and over, after keyhole surgery.
For: complicated acute appendicitisFrance - AuthorisedTherapeutic use (Phase IV)
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
This study looks at how well antibiotics work in very sick patients. Researchers want to make sure these important medicines reach the right levels in the body to fight serious infections effectively and safely. It's about getting the dose just right.
For: Serious infections in critically ill patients treated with antibioticsFrance