- AuthorisedTherapeutic use (Phase IV)
Clinical impact of pharmacokinetic monitoring of antibiotics in critically ill patients
This study looks at how well antibiotics work in very ill patients in intensive care. It checks if carefully tracking antibiotic levels in their bodies helps treat infections and improve how quickly they recover, including how long they stay in hospital.
For: Critical Patients admitted to the ICUSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
RANDOMIZED, CONTROLLED, OPEN, MULTICENTRIC CLINICAL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF A COMBINATION OF ANTI-TUBERCULOUS DRUGS BASED ON HIGH DOSE RIFAMPICIN, HIGH DOSE MOXIFLOXACIN AND LINEZOLID IN PATIENTS WITH BACILLIFEROUS PULMONARY TUBERCULOSIS (RML-TB).
This study is testing new combinations of existing medicines for lung tuberculosis. Researchers want to see if these new combinations work better and are safe, especially for patients whose spit samples still show bacteria. It's an early-stage study to gather important information.
For: Bacilliferous pulmonary tuberculosisSpain - Ongoing, recruitingTherapeutic use (Phase IV)
SePkLin Study: Pragmatic, Multicenter, Randomized, Controlled Clinical Trial in Patients with Sepsis to Evaluate the Safety and Efficacy of Personalized Pk/Pd Dosing Versus Standard Dosing of LINezolid.
This study looks at treating sepsis (a serious infection) with antibiotics. It compares giving a standard dose of the antibiotic linezolid with giving a personalised dose to see which is safer and works better, especially in preventing low platelet counts.
For: SepsisSpain - Ongoing, recruitingPhase III and phase IV (Integrated)
Oral and Neuro-Penetrative Alternative Antibiotics for Patients with Syphilis
This study is looking for better ways to treat syphilis. Researchers are comparing a new antibiotic, Linezolid, with the usual treatment to see which one works best. They're checking if the treatments cure the infection, stop it from coming back, and looking for any side effects.
For: SyphilisSpain - AuthorisedTherapeutic use (Phase IV)
Evaluation of the clinical implementation of biofilm susceptibility to antibiotics using Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC) to guide the treatment of periprosthetic joint infections; a prospective randomized clinical trial
This study looks at how best to treat infections around artificial hip or knee joints. It compares standard test results with a new test to see if combining them helps doctors choose better antibiotics and leads to fewer repeat infections or surgeries.
For: Periprosthetic hip joint infection Periprosthetic knee joint infectionSweden - RecruitingPHASE2, PHASE3
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
This study, called FORMaT, is looking for the best ways to treat a serious lung infection called Mycobacterium abscessus (MABS-PD). It tests different medicines to find the most effective and safest treatments, aiming to improve how people with this condition live.
For: Pulmonary Disease Due to Mycobacteria (Diagnosis)Australia · Denmark · Israel - AuthorisedTherapeutic confirmatory (Phase III)
Feasibility of the Application of a new Six-month Treatment for multidrug-resistant tuberculosis (MDR-TB) patients in France (FAST-MDR)
This study, called FAST-MDR, is looking at a new, shorter 6-month treatment for a severe type of tuberculosis (TB) that is hard to treat with usual medicines. It aims to see if this new treatment works as well as, or better than, older treatments for adults in France.
For: Patients diagnosed at the study sites with rifampicinresistant tuberculosis during the recruitment period will be evaluated for study inclusion.France - AuthorisedTherapeutic use (Phase IV)
TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trial
This study is looking at the best length of antibiotic treatment for liver abscesses, comparing 3 weeks to 6 weeks. It wants to see if shorter treatment is just as effective and safe as longer treatment for patients after their abscess has been drained.
For: Pyogenic liver abscessFrance - AuthorisedTherapeutic use (Phase IV)
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
This study looks at how well antibiotics work in very sick patients. Researchers want to make sure these important medicines reach the right levels in the body to fight serious infections effectively and safely. It's about getting the dose just right.
For: Serious infections in critically ill patients treated with antibioticsFrance