- Ongoing, recruitingPhase I and Phase II (Integrated)- Other
KANDOVA - A two-part Phase Ib/IIa study to evaluate the safety and tolerability of KAND567, in combination with carboplatin therapy, and to determine the Recommended Phase II Dose (RPIID) of KAND567. An open-label, multicenter dose escalation study with an expansion cohort in women with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
This study is looking at a new medicine called KAND567, given alongside standard carboplatin chemotherapy, for women with ovarian, fallopian tube, or primary peritoneal cancer that has come back. It aims to see how safe it is and find the best dose.
For: Recurrent epithelial ovarian · fallopian tube · or primary peritoneal cancer.Denmark · Norway · Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
Influence of Argipressin on blood loss during liver resection; a double-blinded, randomized, placebo-controlled trial (ARG-01)
This study looks at whether a medicine called argipressin can help reduce blood loss during liver surgery. Doctors will compare it to a dummy treatment (placebo) to see if it makes a difference and if it's safe for patients having liver operations.
For: Hepatic resection due to primary malignant disease · metastasis or benign tumourSweden - AuthorisedTherapeutic exploratory (Phase II)
Chemoimmunotherapy in conjunction with blood-brain-barrier opening in patients with newly diagnosed or relapsed primary central nervous system lymphoma
This study looks at new ways to treat a rare type of brain lymphoma in adults. It combines chemotherapy with newer immune-boosting drugs. Doctors want to see if this treatment helps patients live longer, whether they are newly diagnosed or if their cancer has returned.
For: Primaari aivolymfomaa · ensilinjan hoito tai hoito relapoituneessa tai refraktaarissa taudissaFinland - AuthorisedTherapeutic use (Phase IV)
Aciclovir for HSV-2 MENingitis: A double-blinded randomised controlled trial (AMEN)
This study is looking at whether a medicine called aciclovir can help people with meningitis caused by the herpes simplex virus (HSV-2). It's a follow-up study (Phase IV) to see if the treatment works well in everyday medical care and to learn more about its effects.
For: HSV-2 meningitisDenmark - AuthorisedTherapeutic use (Phase IV)
Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomized clinical trial
This study looks at different pain medicines (methadone, fentanyl, and oxycodone) after heart surgery. It wants to find out which one best reduces pain and limits the amount of strong pain relief needed, aiming for fewer problems and a better recovery for patients.
For: Following heart surgery · patients experience poor postoperative pain control and a moderate/high opioid consumptions. This is correlated to adverese events and poor outcome.Denmark - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A double-blind, randomised, placebo-controlled, first-in-human (FIH) Phase I/IIa, multi-centre trial to assess safety, tolerability, and immune response of single and multiple ascending doses of TOL2 (Immune Tolerising Agent) in patients with generalised myasthenia gravis
This study is testing a new medicine, TOL2, for generalised myasthenia gravis. It's looking at how safe the medicine is, how well people can tolerate it, and if it affects the body's immune system. This is an early-stage UK trial.
For: generalised myasthenia gravisGermany · Denmark · Sweden - AuthorisedTherapeutic use (Phase IV)
Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
This study looks at how different amounts of the medicine thiopental, used for sleep during electroconvulsive therapy (ECT), affect treatment for severe depression. Researchers want to see if a lower dose works better than a higher dose for improving mood.
For: Major depressive disorderSweden - AuthorisedTherapeutic exploratory (Phase II)
Neoadjuvant pembrolizumab in patients with stage IIb/c melanoma, a phase II double-blind placebo-controlled randomized trial NEOPRIME
This study looks at a new way to treat an advanced type of skin cancer called melanoma before surgery. It tests a drug called pembrolizumab (Keytruda) to see if it can shrink the cancer and make surgery more effective, hoping to improve long-term outcomes for patients.
For: Stage IIb/c melanomaSweden - AuthorisedPhase III and phase IV (Integrated)
Contrast Strategy In Fenestrated EndoVascular Aneurysm Repair Randomized Control Trial
This study looks at different X-ray dyes used during a keyhole surgery for a bulge in the main body artery. We're checking which dye is safer for your kidneys and how well they help doctors see during the operation.
For: Abdominal aortic aneurysmSweden - AuthorisedTherapeutic use (Phase IV)
Multicentre, open-label, randomized controlled non-inferiority trial comparing single dose intrathecal morphine and continuous thoracic epidural analgesia for multimodal analgesia in open colorectal surgery: the ColoREDIT protocol
This study compares different pain relief methods after bowel surgery. It looks at whether a single morphine injection into the spine is as good as continuous pain medicine delivered through a small tube in the back to help patients recover well and manage pain during their recovery.
For: All diseases requiring resective colorectal surgery with a midline incision.Sweden - AuthorisedTherapeutic confirmatory (Phase III)
CYPENZA - A prospective cohort trial on antiandrogens influences on the pharmacokinetics of corticosteroids.
This study looks at how medicines for prostate cancer (antiandrogens like enzalutamide or apalutamide) might change how a steroid medicine (dexamethasone) works in the body. We want to see if these cancer drugs affect the amount of dexamethasone in your blood.
For: Prostate cancerSweden - AuthorisedTherapeutic exploratory (Phase II)
Comparison of esketamine mouthwash versus intravenous administration for the treatment of chemotherapy/radiotherapy-induced mucositis
This study compares esketamine mouthwash with an intravenous (IV) drip for treating mouth sores caused by cancer treatment. We want to see if the mouthwash works just as well to reduce pain, aiming to find an easier way to help patients.
For: Oral mucositisNetherlands - AuthorisedTherapeutic confirmatory (Phase III)
EPISSOC : Randomized controlled trial comparing an Early Pleural Irrigation strategy with Saline to the Standard of Care for the management of complicated pleural infections
This study compares different ways to treat serious chest infections, called pleural infections. It looks at whether an early wash-out procedure using salt water is better than standard care to help patients recover and avoid further treatments or surgery. It's a phase 3 trial, meaning it's testing for effectiveness.
For: Pleural infectionsFrance - AuthorisedTherapeutic use (Phase IV)
Comparing intraoperative indocyanine green fluorescence imaging with standard clinical assessment for flap perfusion in head and neck reconstruction: A randomised controlled Trial (VISION Trial)
This study looks at a new way to check blood flow during surgery for head and neck cancer. It compares a special dye injection with the usual methods to see if it helps reduce problems with tissue flaps used for reconstruction.
For: Head and neck cancerSweden - AuthorisedTherapeutic confirmatory (Phase III)
Prognostic Performance of Quantitative Myocardial Perfusion Imaging Using H2[15O] Positron Emission Tomography in Coronary Artery Disease - The AQUA COR trial
This study is looking at a special heart scan called quantitative myocardial perfusion imaging using H2[15O] PET. It aims to see how well this scan can predict future heart problems like heart attacks or death in people with heart disease over up to 10 years. It will help doctors understand who is most at risk.
For: Cardiovascular diseaseSweden - Ongoing, recruitingTherapeutic use (Phase IV)
The Intertransverse Process Block - Single or Multiple Injection? A randomised, procedure related, blinded crossover trial in healthy volunteers
For: The ITP block is primarily used for pain amelioration after breast cancer surgery.Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Experimental Study on Alcohol Use and Behavior in Young Adults
For: Alcohol Use Disorder (AUD)Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase 2, randomised, double-blind, placebo-controlled trial to evaluate safety and local tolerability of four weekly administrations of A24110He in subjects with elevated triglyceride plasma concentrations
For: Moderate to severe hypertriglyceridemiaSweden - AuthorisedTherapeutic exploratory (Phase II)
HEMO trial - A randomized controlled trial of heparin bolus mobilization prior to peripheral hematopoietic cell collection from patients with lymphoma or myeloma
For: Myelom · LymfomSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Double-blind, Placebo-controlled, Randomised Trial Investigating the Effect of AZD3427 on Renal Perfusion in HFrEF Patients With Renal Impairment Using Positron Emission Tomography (PET)
For: Heart failure with reduced ejection fraction · Renal impairmentSweden - AuthorisedTherapeutic use (Phase IV)
TailorDose®-II: Therapeutic dose monitoring of commonly used cytostatic drugs/regimes indicated for breast cancer
For: Breast cancer female NOSSweden