- Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I-II Study to Assess the Safety, Tolerability and Efficacy of Lurbinectedin and Dostarlimab in Advanced/Recurrent Endometrial Cancer Patients with Disease Progression after Prior Therapy with Platinum-based Chemotherapy. LiDer trial
This study is looking at a new combination treatment for advanced womb cancer that has come back or spread after previous chemotherapy. It aims to see how safe and effective lurbinectedin and dostarlimab are together in hopefully shrinking tumours.
For: Advanced/Recurrent Endometrial Cancer Patients with Disease Progression after Prior Therapy with Platinum-based ChemotherapySpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Open-label, Phase III Study of Lurbinectedin Single-Agent or Lurbinectedin in Combination with Irinotecan versus Investigator’s Choice (Topotecan or Irinotecan) in Relapsed Small Cell Lung Cancer (SCLC) Patients (LAGOON Trial)
This study looks at new ways to treat small cell lung cancer that has come back. It compares a drug called lurbinectedin, alone or with irinotecan, against standard treatments to see which helps patients live longer and clearer of cancer.
For: Small Cell Lung Cancer (SCLC)Poland · France · Germany - Active not recruitingPHASE3
Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo)
This study compares a new drug combination (Lurbinectedin and Doxorubicin) against Doxorubicin alone for people with advanced leiomyosarcoma, a rare type of cancer. It aims to see if the combination can keep the cancer from growing for longer.
For: LeiomyosarcomaUnited States · Austria · Belgium - Active not recruitingPHASE3
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
This study is looking at a new treatment called Tarlatamab for advanced small cell lung cancer that has come back after earlier treatment. We want to see if Tarlatamab helps people live longer compared to standard chemotherapy.
For: Small Cell Lung Cancer (SCLC)United States · Argentina · Australia - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
“Phase I/II, Multicenter, Open-label, Clinical and Pharmacokinetic Study of Lurbinectedin (PM01183) in Combination with Pembrolizumab in Patients with Relapsed Small Cell Lung Cancer (the LUPER study).”
This study looks at a new combination of two drugs, Lurbinectedin and Pembrolizumab, for people with small cell lung cancer that has come back. It aims to find the safest dose and see how well the combination works.
For: Small cell lung cancer (SCLC).Spain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I/II, Multicenter, Open-label, Clinical and Pharmacokinetic Study of Lurbinectedin in Combination with Irinotecan in Pretreated Patients with Selected Advanced Solid Tumors
This study is testing a new combination of medicines, lurbinectedin and irinotecan, for people with advanced cancers that have already been treated. It aims to find the right dose and see how well it works and if it's safe.
For: Selected Advanced Solid TumorsSpain · France · Italy - Active not recruitingPHASE3
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
This study looks at treating a specific type of advanced lung cancer. It compares two treatments, atezolizumab alone or combined with lurbinectedin, after initial chemotherapy. The aim is to see which approach works best to keep the cancer stable.
For: Small-Cell Lung CancerUnited States · Belgium · Germany - RecruitingPHASE3
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
This study is looking at a new medicine called ifinatamab deruxtecan (I-DXd) for small cell lung cancer that has come back. It compares I-DXd to standard treatments to see if it works better and is safe.
For: Small Cell Lung CancerUnited States · Australia · Austria