- Ongoing, recruitingTherapeutic use (Phase IV)
Predictive factors and magnitude of response to omalizumab and mepolizumab in allergic and eosinophilic severe asthma: PREDICTUMAB, an open-label, controlled, randomized multinational pragmatic trial.
This study compares two existing asthma medications, omalizumab and mepolizumab, for people with severe allergic or eosinophilic asthma. It aims to see which treatment better prevents severe asthma attacks and how well each drug works overall in different groups of people.
For: Severe allergic and eosinophilic asthmaBelgium · France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, 52-week, open-label, single arm study to investigate the efficacy and safety of mepolizumab SC in participants aged 6 to 17 years with hypereosinophilic syndrome.
This study is for young people aged 6 to 17 with a rare blood condition called hypereosinophilic syndrome (HES). It's testing a medicine called mepolizumab to see if it can reduce how often their symptoms flare up and to check if it's safe.
For: Hypereosinophilic syndrome (HES)Spain · Netherlands - Active not recruitingPHASE3
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
This study is looking at two medicines, Depemokimab and Mepolizumab, for adults with a rare condition called EGPA. We want to see how well they work and if they are safe when patients are already having standard treatment.
For: Eosinophilic Granulomatosis With PolyangiitisUnited States · Argentina · Austria - Active not recruitingPHASE3
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.
This study compares two treatments, benralizumab and mepolizumab, for a rare condition called Eosinophilic Granulomatosis with Polyangiitis (EGPA). Researchers want to see which one works better and is safer for people whose EGPA keeps coming back or isn't well controlled, even with other medicines.
For: Eosinophilic Granulomatous VasculitisUnited States · Belgium · Canada