- Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
For: Ulcerative ColitisCzechia · Spain · Poland - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
TEMPLE - Thiopurine Enhanced Mutations for PD-1/Ligand-1 Efficacy
This study is testing new ways to treat cancer. It combines standard cancer drugs with newer immunotherapy to see if they work better together. Researchers are also looking for the best dose and how safe this new treatment is.
For: OncologyDenmark - AuthorisedPhase I and Phase II (Integrated)- Other
ABT-199 (Venetoclax) and Purine analogues as Novel Oral Drug Combination for Treatment of Relapsed/Refractory Acute Myeloid Leukemia (ApoAML)
This study looks at new drug combinations for adults with Acute Myeloid Leukaemia (AML) that has come back or not responded to previous treatment. It tests venetoclax and mercaptopurine together to see how well they work and if they are safe.
For: Acute myeloid leukemiaBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Multicenter Induction Study with an Active Treatment Extension to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vixarelimab in Patients with Moderate to Severe Ulcerative Colitis
This study is testing a new drug, called Vixarelimab, for adults with moderate to severe ulcerative colitis. It aims to see how well it works to reduce symptoms and improve the gut, as well as checking its safety and how the body handles it.
For: Ulcerative Colitis (UC)Belgium · Germany · France