- AuthorisedTherapeutic use (Phase IV)
Methadone versus fentanil and oxycodone for post-operative pain reduction in patients undergoing coronary artery bypass grafting and/or valve surgery – a placebo-controlled, double-blind, randomized clinical trial
This study looks at different pain medicines (methadone, fentanyl, and oxycodone) after heart surgery. It wants to find out which one best reduces pain and limits the amount of strong pain relief needed, aiming for fewer problems and a better recovery for patients.
For: Following heart surgery · patients experience poor postoperative pain control and a moderate/high opioid consumptions. This is correlated to adverese events and poor outcome.Denmark - Ongoing, recruitingPhase III and phase IV (Integrated)
Perioperative methadone compared to placebo in elderly hip fracture patients – a randomized controlled trial. Phase two of the MetaHip trial
This study looks at whether a medicine called methadone can help older people who have had a hip fracture manage their pain better and reduce how much strong pain medication they need. It also checks for side effects like sickness and confusion.
For: Hip fracturesDenmark