Methylprednisolone clinical trials
27 indexed studies · 4 currently recruiting
- RecruitingPHASE3
Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis
This study looks at a new way to treat bowel inflammation (colitis) caused by cancer medicines called immune checkpoint inhibitors. It compares standard steroids with steroids plus a drug called infliximab to see which works best and fastest.
For: ColitisDenmark · United Kingdom - AuthorisedTherapeutic confirmatory (Phase III)
Utility of the use of N-acetylcysteine associated with conventional treatment in patients with severe acute alcoholic hepatitis (Maddrey>=32)
This study looks at whether adding a medication called N-acetylcysteine (NAC) to standard treatment helps people with severe alcoholic hepatitis. Researchers want to see if this combination improves survival in the first month and reduces other serious problems.
For: Acute Alcoholic hepatitisSpain - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
This study looks at a new, higher dose of ocrelizumab for people with primary progressive multiple sclerosis (PPMS). Researchers want to see if this dose is safe and works better than the current approved dose to slow down the disease.
For: Multiple SclerosisUnited States · Argentina · Belgium - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
This study is testing a new treatment, LY3884961, for babies with a serious inherited condition called Type 2 Gaucher disease. Researchers want to see if it's safe and effective. It's a long-term study, following babies for up to 5 years.
For: Gaucher Disease, Type 2United States · United Kingdom - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
This study is looking into a new treatment called Obinutuzumab for a condition called lupus (Systemic Lupus Erythematosus). It compares this new treatment with a dummy treatment (placebo) to see if it's safe and effective for people already getting standard lupus care.
For: Systemic Lupus ErythematosusUnited States · Argentina · Brazil - RecruitingPHASE3
High Dose Steroids in Children With Stroke
This study looks at whether strong anti-inflammatory medicines (steroids) can help children recover from a type of stroke called focal cerebral arteriopathy (FCA). Scientists want to see if steroids, given alongside standard care, lead to better and faster recovery.
For: Paediatric StrokeAustralia · Austria · Denmark - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
This study is testing a new medicine, LY3884963, for Frontotemporal Dementia (FTD) caused by a specific gene change. It will check if the medicine is safe, how it affects a protein called progranulin, and if it helps patients.
For: Frontotemporal DementiaUnited States · Australia · Belgium - Active not recruitingPHASE3
SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM
This study is looking at a new way to give a medicine called isatuximab for a type of blood cancer called multiple myeloma. It compares giving the medicine as a shot under the skin versus through a drip into a vein, always with other standard treatments.
For: Plasma Cell Myeloma RecurrentUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.
For: Kidney Transplant RejectionAustralia · Chile · China - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy B – Relapsed/Refractory Richter Transformation (RT)
This study looks at a new cell therapy called Tecartus for adults with a type of blood cancer called Richter Transformation that has come back or not responded to previous treatments. It aims to see how well it works and if it's safe.
For: Relapsed/refractory Richter Transformation (RT)France · Germany · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy C – Relapsed/Refractory Burkitt Lymphoma (BL)
This study is looking at a new treatment called Tecartus for adults in the UK with a specific type of blood cancer called Burkitt Lymphoma. It's for patients whose cancer has come back or hasn't responded to previous treatments. Researchers want to see how well Tecartus works.
For: Relapsed/Refractory Burkitt Lymphoma (BL)Netherlands · France · Austria - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA-25) – Substudy D - Relapsed/Refractory Hairy Cell Leukemia (HCL)
This study looks at a new cell therapy called Tecartus for adults with a rare blood cancer called hairy cell leukaemia. It aims to see how well it works and if it's safe for people whose cancer has come back or hasn't responded to previous treatments.
For: Relapsed/Refractory Hairy Cell LeukemiaNetherlands · Spain · Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA-25) – Substudy A – Relapsed/Refractory Waldenstrom Macroglobulinemia
This study is testing a new cell therapy called Tecartus for adults in the UK with a rare blood cancer called Waldenstrom Macroglobulinemia. It's for people whose cancer has come back or hasn't responded to previous treatments. We want to see how well it works and if it's safe.
For: Relapsed/Refractory Waldenstrom Macroglobulinemia (WM)Netherlands · Spain · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 open-label, controlled, randomised, multi-centre trial comparing imlifidase and standard-of-care with standard-of-care alone in the treatment of severe anti-GBM antibody disease (Goodpasture disease)
This study is testing a new medicine, Idefirix, for a rare kidney disease called Goodpasture disease. Researchers want to see if Idefirix, along with usual care, helps kidney function better than usual care alone over six months.
For: Anti-GBM antibody disease (Goodpasture disease)Spain · Czechia · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Controlled Double-blind, Multicenter Study Comparing the Efficacy and Safety of Zetomipzomib (KZR-616) 30 mg or 60 mg with Placebo in Patients with Active Lupus Nephritis
This study is looking at a new medicine called Zetomipzomib (KZR-616) for people with lupus affecting their kidneys. Researchers want to see if it's safe and helps improve kidney function compared to existing treatments, using different dose levels.
For: Autoimmune diseasePortugal · Germany · Greece - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Week, Phase 2 Open-Label, Sequential Dose Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 Treatment in Participants with Congenital Adrenal Hyperplasia
This study is looking at a new treatment called CRN04894 for people with Congenital Adrenal Hyperplasia (CAH). It will check if the treatment is safe, how well it works, and how the body handles it. This is an early-stage study.
For: CONGENITAL ADRENAL HYPERPLASIAGermany · Italy - Ongoing, recruitingTherapeutic exploratory (Phase II)
A PHASE 2 MULTICENTER STUDY OF AXICABTAGENE CILOLEUCEL IN SUBJECTS WITH RELAPSED/REFRACTORY INDOLENT NON-HODGKIN LYMPHOMA (INHL)
This study looks at a new type of cell therapy, Yescarta, for people with certain types of slow-growing non-Hodgkin lymphoma that has come back or hasn't responded to other treatments. Researchers are checking how well it works and if it's safe over many years.
For: Follicular Lymphoma · Marginal Zone Lymphoma · Indolent Non-Hodgkin LymphomaFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, ADAPTIVE PHASE III TRIAL TO INVESTIGATE EFFICACY AND SAFETY OF VILOBELIMAB IN THE TREATMENT OF ULCERATIVE PYODERMA GANGRENOSUM
This study is testing a new medicine called Gohibic for people with a skin condition called ulcerative pyoderma gangrenosum. It compares Gohibic to other treatments or a dummy medicine to see if it helps heal the ulcers and reduces pain, with the aim of finding better ways to treat this condition.
For: ulcerative pyoderma gangrenosumBelgium · Hungary · Poland - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase I/II, open-label, dose escalation study to evaluate the safety of 2 doses of intravenous ATA-200, an adeno-associated viral vector carrying the human gamma-sarcoglycan gene, in patients with gamma-sarcoglycanopathy (limb-girdle muscular dystrophy LGMDR5, formerly LGMD2C).
This study is testing a new gene therapy for a rare muscle condition called limb-girdle muscular dystrophy type R5 (LGMD-R5). It aims to see if the treatment is safe, what dose works best, and if it helps improve muscle function.
For: limb-girdle muscular dystrophy type R5 (previously named LGMD2C)France · Italy - AuthorisedTherapeutic confirmatory (Phase III)
High Dose Steroids in Children with Stroke and Unilateral Focal Arteriopathy: A Multicentre Randomized Controlled Trial
This study looks at using strong steroid medicines to treat a type of stroke in children called focal cerebral arteriopathy (FCA). Researchers want to see if these medicines can reduce the inflammation in blood vessels and improve children's recovery.
For: Focal cerebral arteriopathy and childhood stroke Focal cerebral arteriopathy (FCA) is an inflammatory vessel wall disease provoked by infection.France · Austria · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
EFRAIM II _ Empirical steroids and/or antifungals in immunocompromised patients with acute respiratory failure from undetermined etiology: a multicenter double-blind randomized controlled trial
This study is looking at new ways to treat very sick patients in intensive care who have serious breathing problems. We want to find out if certain medicines, like special steroids or anti-fungal drugs, can help these patients recover better and improve their chances of survival.
For: patients with acute respiratory failure from undetermined etiologyFrance - AuthorisedTherapeutic confirmatory (Phase III)
SEM-CORTICO.Severe erythema multiform: A randomized controlled trial com-paring a short systemic corticosteroids regimen to placebo in the acute established phase.
This study looks into treating severe erythema multiforme, a serious skin condition, with a short course of steroid tablets like prednisolone. They want to see if this helps patients get better faster compared to a dummy treatment, focusing on pain control and eating.
For: Erythema multiforme (EM) in its severe form managed at the hospitalFrance - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
For: Lupus NephritisUnited States · Argentina · Brazil - AuthorisedTherapeutic exploratory (Phase II)
Pulse corticosteroids or/and Immunoglobulins to treat fulminant Myocarditis: a double-blind randomized controlled adaptive trial (The CORIUM study)
This study looks at new ways to treat a serious heart condition called fulminant myocarditis. Researchers are testing if special medications, corticosteroids and immunoglobulins, can help patients recover better and quicker, focusing on improving heart function and survival.
For: Fulminant myocarditisFrance - AuthorisedTherapeutic exploratory (Phase II)
The HIt HArd and hiT early in multiple sclerosis trial – HiHat trial
This study, called HiHat, is looking into new treatments for relapsing-remitting multiple sclerosis (MS) in people who have had the condition for less than 10 years. It's investigating if certain medicines can stop MS from getting worse, while making sure they are safe.
For: Patients with relapsing-remitting multiple sclerosis with less than 10 years disease duration.Sweden - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
This study is testing a higher dose of a medicine called ocrelizumab for adults with a type of multiple sclerosis (MS) called relapsing MS. It compares the new dose to the standard dose to see if it's more effective and safe.
For: Multiple SclerosisUnited States · Argentina · Australia