- Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized Phase 2, double-blind, placebo-controlled, parallel-group, 2-arm study to assess the efficacy, safety, and tolerability of subcutaneous lunsekimig in adult participants with chronic rhinosinusitis with nasal polyps (CRSwNP)
This study looks at a new medicine called lunsekimig for adults with long-term stuffy nose and growths called nasal polyps. It compares lunsekimig to a dummy medicine to see if it makes symptoms better and if it's safe.
For: Respiratory tract diseasesBulgaria · Poland · Belgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
This study is looking into a new tablet called brensocatib for adults with long-term sinus problems that don't involve growths (nasal polyps). It wants to see if this new medicine can help reduce symptoms like stuffy nose and improve how people feel, compared to a dummy pill.
For: Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)Bulgaria · Czechia · Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess the Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects with Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) Allergy
This study is testing a new injection called PURETHAL Mites to see if it can help adults with hay fever-like symptoms or asthma caused by house dust mites. It compares the injection to a dummy treatment (placebo) to see if it reduces their allergy symptoms.
For: Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) AllergyLithuania · Germany · Latvia - Ongoing, recruitingTherapeutic use (Phase IV)
Characterisation and intervention study in patients with long-term use of nasal decongestants.
This study looks at helping people stop using nasal sprays too much. It tests a steroid nasal spray (Mometasone) to see if it can help them overcome blocked noses caused by over-using decongestant sprays, and if they can stay off the old sprays.
For: rhinitis medicamentosaBelgium