- Active not recruitingPHASE1
A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months
This study is testing new mRNA vaccines against common winter viruses, RSV and hMPV, in babies and toddlers aged 5 to 24 months. Researchers want to see if the vaccines are safe and good at triggering the body's immune response.
For: Respiratory Syncytial Virus · Human MetapneumovirusUnited States · Australia · Canada - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Reactogenicity, Safety, and Immunogenicity of mRNA-1345, an mRNA Vaccine Targeting Respiratory Syncytial Virus, in Pregnant Women, and Safety, and Immunogenicity in Infants Born to Vaccinated Mothers.
This study is testing a new vaccine for pregnant women to protect their babies from RSV, a common chest infection. We're looking at how safe the vaccine is, its side effects, and how well it helps the mother and baby fight off RSV.
For: Respiratory syncytial virusDenmark - Active not recruitingPHASE3
A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in High-risk Adults
This study is testing a new vaccine (mRNA-1345) to protect against Respiratory Syncytial Virus (RSV) in adults at higher risk. It aims to see how safe the vaccine is and how well the body's immune system responds to it. The study involves two groups: high-risk adults and organ transplant recipients.
For: Respiratory Syncytial VirusUnited States · Canada · Puerto Rico - Active not recruitingPHASE2
A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers
This study is looking at a new vaccine (mRNA-1345) for Respiratory Syncytial Virus (RSV) in pregnant women. It checks if the vaccine is safe and works well for mums-to-be, and also for their babies after they are born.
For: Respiratory Syncytial VirusUnited States · Canada · Chile - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Observer-blind, Placebo-controlled, Age De-escalation Study of the Safety, Tolerability, and Immunogenicity of mRNA-1345 and mRNA-1365 in Participants Aged 5 months to < 24 months
This study is looking at how safe new vaccines are for babies aged 5 to 23 months. It's testing two different vaccines (mRNA-1345 and mRNA-1365) to see if they help protect against chest infections, like those caused by RSV. Scientists are checking for any side effects and how well the vaccines boost the babies' immune systems.
For: Acute lower respiratory infectionSpain · Latvia · Poland