mycophenolate mofetil clinical trials
10 indexed studies · 4 currently recruiting
- RecruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.
For: Kidney Transplant RejectionAustralia · Chile · China - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 Monotherapy and MEDI4736 in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Unresectable Stage IV Urothelial Cancer
This study looks at new treatments for advanced bladder cancer that can’t be removed by surgery. It compares two new medicines, alone or together, against standard chemotherapy to see which helps people live longer and stops cancer from growing.
For: ureters · urinary bladder · and urethra)Spain · Greece - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination with either Durvalumab Monotherapy or Durvalumab plus Bevacizumab Therapy in Patients with Locoregional Hepatocellular Carcinoma (EMERALD-1)
This study is testing new ways to treat a type of liver cancer that hasn't spread far. It combines a standard treatment (TACE) with new medicines (durvalumab, sometimes with bevacizumab) to see if they help people live longer without their cancer growing.
For: Locoregional Hepatocellular Carcinoma (HCC)Italy · France · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Multicentre, Open-Label Study to Assess the Efficacy and Safety of Olaparib Monotherapy and Olaparib Plus Durvalumab Combination as Neoadjuvant Therapy in Patients with BRCA Mutations and Early Stage HER2- negative Breast Cancer (OlympiaN)
This study is looking at new ways to treat a specific type of early breast cancer in people with a gene change called a BRCA mutation. It tests two medicines, olaparib alone and olaparib with durvalumab, to see how well they shrink tumours before surgery and if they are safe.
For: BRCA Mutations and Early Stage HER2-Negative Breast CancerGermany · Belgium · Austria - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III Randomised, Double-Blind, Placebo-Controlled, Multicentre Study of Durvalumab in Combination with Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib in Newly Diagnosed Advanced Ovarian Cancer Patients (DUO-O).
This study looks at new treatments for advanced ovarian cancer. It combines standard chemotherapy with newer drugs, durvalumab and bevacizumab, and then adds olaparib. We want to see if this combination helps patients live longer without their cancer growing.
For: Newly diagnosed advanced (FIGO stage III-IV) high grade epithelial ovarian · fallopian or primary peritoneal cancerBelgium · Italy · Spain - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - RecruitingPHASE3
A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications
This study compares two ways to help young people (12-17) after a kidney transplant. It looks at changing medicine from one type (calcineurin inhibitor) to another (belatacept-based) and how well patients stick to their treatment. It aims to see which approach works best.
For: Renal Allograft RecipientsUnited States · Argentina · Belgium - AuthorisedTherapeutic confirmatory (Phase III)
A Phase III, Randomised, Open-label, Global Study of Adjuvant Datopotamab Deruxtecan (Dato-DXd) in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma Non-small Cell Lung Cancer who are ctDNA-positive or Have High-risk Pathological Features (TROPION Lung12)
This study looks at new treatments for early-stage lung cancer, specifically adenocarcinoma non-small cell lung cancer, after surgery. It compares a new drug combination, Datopotamab Deruxtecan with Rilvegostomig, or Rilvegostomig alone, against current standard treatments to see which works best at preventing the cancer from coming back.
For: Stage I adenocarcinoma non-small cell lung cancer (NSCLC) with ctDNA-positive result or high-risk pathological featureNetherlands · Spain · Hungary - AuthorisedTherapeutic use (Phase IV)
Safety and efficacy of steering of immunosuppression based on BKPyV-specific T cells in case of BK Polyomavirus (BKPyV) DNAe- mia after kidney transplantation
This study looks at how well a new approach to adjusting medicines helps control a common virus called BK Polyomavirus (BKPyV) in people who have had a kidney transplant. The goal is to find the best way to keep the new kidney healthy.
For: BK Polyomavirus DNAemia after kidney transplantationGermany - RecruitingPHASE2
Methods of T Cell Depletion Trial (MoTD)
This study compares different ways to prevent a complication called GvHD after stem cell transplants for various blood cancers. It's looking for the best treatment plan to help patients recover well, using common medicines like Thymoglobulin, Cyclophosphamide, Cyclosporine, Sirolimus, and Mycophenolate Mofetil.
For: Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Chronic Myelomonocytic LeukemiaUnited Kingdom