- Ongoing, recruitingTherapeutic use (Phase IV)
Effect of intravenous Lidocaine bolus on the median effective concentration (EC50) of Propofol during target controlled infusion (TCI : Schnider model) for gastroscopy in adult patients : a prospective, randomized, double-blinded study
This study looks at how a common painkiller called lidocaine, given through a drip, might help reduce the amount of a sleep-inducing medicine (propofol) needed for a gastroscopy. It aims to make the procedure smoother and more comfortable for adult patients.
For: GastroscopyBelgium - Ongoing, recruitingTherapeutic use (Phase IV)
Perioperative oral analgesia versus intravenous analgesia for knee arthroscopy, a randomized, double-blinded, non-inferiority trial. OVIKA-trial - S68618
This study, called OVIKA, is looking at the best way to manage pain after a common knee operation. Researchers are comparing pain relief given through an IV drip with pain relief given as tablets to see if tablets work just as well for knee pain.
For: Postoperative pain relief after knee arthroscopyBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(REGON) Repeated corticosteroid injections around the Greater Occipital Nerve (GON) as prophylactic treatment in chronic cluster headache
This study looks at whether regular injections around a nerve in the back of the head can help prevent severe "cluster headaches." It compares a pain-relieving medicine with a dummy injection to see how long people stay free from their usual headache patterns.
For: Cluster headacheNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Selän alueen poikkeava aktiivisuus servikaalisessa dystoniassa
This study looks at how abnormal muscle activity in the back is linked to cervical dystonia, a condition causing twisted neck positions. It compares different botulinum toxin injections (like Botox) to see how well they reduce muscle overactivity and improve symptoms.
For: Servikaalinen dystonia · jossa poikkeavaa lihasaktiivisuutta esiintyy kaulan alueen lihaksissa aiheuttaen tyypillisiä virheasentoja kuten pään kiertymistä · kallistumista ja vapinaa. Servikaalista dystoniaa hoidetaan ensisijaisesti paikallisesti botuliinitoksiinipistoksillaFinland - Ongoing, recruitingTherapeutic exploratory (Phase II)
CONCOMITANT ADMINISTRATION OF LICENSED VACCINES AGAINST COVID-19 AND FLU WITH OR WITHOUT MF59 ADJUVANT: A MULTI-CENTRE, RANDOMIZED, SINGLE-BLIND CLINICAL TRIAL TO ASSESS IMMUNOGENICITY IN ADULTS AGED 65 AND OVER
This study looks at giving COVID-19 and flu vaccines at the same time to people aged 65 and over. We want to see how well their bodies respond to both vaccines and if it's safe to have them together. This could make it easier for older adults to stay protected.
For: COVID-19 and fluBelgium · Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
ANA4CKD - Randomized multicenter double-blind controlled trial comparing anakinra to prednisone for gout flare in patients with chronic kidney disease stage 4-5 or kidney transplantation
This study is looking at two treatments for painful gout attacks in people with kidney disease or a kidney transplant: anakinra and prednisone. Researchers want to see which one works better and causes fewer side effects by measuring pain levels and other health changes.
For: Men and women over 18 years of age with renal failure renal failure stages 3b/4/5 · renal transplantation or dialysis and an untreated gout attackFrance - Ongoing, recruitingPhase III and phase IV (Integrated)
Routine versus selective protamine administration to reduce bleeding complications after transcatheter aortic valve implantation
This study looks at using a medicine called protamine to help prevent serious bleeding after a heart procedure called TAVI. Researchers want to see if giving protamine to everyone or only some patients makes a difference to safety and recovery after TAVI.
For: Aortic stenosisNetherlands · Belgium - AuthorisedTherapeutic confirmatory (Phase III)
ZAMBA: Zoledronic Acid for Modic Back Pain. A randomized, double blind, placebo-controlled, multicenter trial
This study, called ZAMBA, is looking at whether a medicine called zoledronic acid can help people with ongoing back pain. It compares this medicine to a dummy treatment (placebo) to see if it improves daily activities and pain levels over one year.
For: Low Back PainNorway