- AuthorisedTherapeutic exploratory (Phase II)
A Phase II, Open-Label, Single Arm, prospective, multicenter study of niraparib plus dostarlimab in patients with pleural mesothelioma positive for PD-L1 expression and germline or somatic mutations in the HRR genes
This study looks at a new combination of two medicines, niraparib and dostarlimab, for people with a type of lung cancer called pleural mesothelioma. Researchers want to see if this treatment can stop the cancer from growing for longer periods.
For: NON SMALL CELL LUNG CANCER · PLEURAL MESOTHELIOMAItaly - Active not recruitingPHASE3
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
This study looks at a new drug, Niraparib, for certain types of breast cancer: HER2-negative with a faulty BRCA gene or triple-negative breast cancer. It investigates if Niraparib is better than a dummy pill (placebo) after surgery or standard treatment.
For: Neoplasms, BreastUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
This study is looking at a new treatment for men with prostate cancer that has spread and is responding to hormone therapy. It combines a drug called niraparib with standard treatments (abiraterone acetate and prednisone) to see if it works better for those with specific genetic changes.
For: Metastatic Castration-sensitive Prostate CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
This study is testing a new combination of medicines, niraparib and abiraterone, with prednisone, for men with advanced prostate cancer that has spread and is resistant to hormone therapy. It compares this new combination against the standard treatment of abiraterone and prednisone to see if it works better.
For: Castration-Resistant Prostatic CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
This study looks at new ways to treat advanced or returning womb cancer. It compares a drug called dostarlimab, with or without another drug called niraparib, alongside standard chemotherapy, against chemotherapy plus a dummy drug, to see if these new treatments work better and are safe.
For: NeoplasmsUnited States · Belarus · Belgium - Active not recruitingPHASE3
A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
This study is looking at a new medicine called Niraparib to see if it can help women with advanced ovarian cancer stay well for longer after their first round of chemotherapy. It’s comparing Niraparib to a dummy drug (placebo).
For: Ovarian NeoplasmsUnited States · Belgium · Denmark - Active not recruitingPHASE2
Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)
This study is for women with ovarian cancer that has come back after treatment with certain drugs (PARP inhibitors). It's looking at new combinations of medicines (tuvusertib with niraparib or lartesertib) to see how well they work and if they are safe.
For: Ovarian CancerUnited States · Australia · Belgium - Active not recruitingPHASE1
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This study is testing new ways to give medicines called niraparib and abiraterone acetate for men with advanced prostate cancer. Researchers want to see how well different forms of these drugs are absorbed by the body to help patients get the best treatment.
For: Prostatic NeoplasmsUnited States · Belgium · France - RecruitingPHASE3
Personalized Medicine for Advanced Biliary Cancer Patients
This study looks at whether adding a special "targeted" drug after initial treatment for advanced bile duct cancer works better than continuing standard treatment. It customises treatment based on your tumour's unique features.
For: Biliary Tract NeoplasmsBelgium · France · United Kingdom - Active not recruitingPHASE3
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
This study compares new drug combinations (dostarlimab and niraparib) with standard care for women newly diagnosed with advanced ovarian cancer. It aims to see if these new treatments can stop the cancer from growing for longer.
For: Ovarian Neoplasms · Ovarian, Fallopian Tube and Primary Peritoneal CarcinomaUnited States · Belarus · Belgium - RecruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
For: Glioblastoma · GBM · Brain Neoplasms, Adult, MalignantUnited States · Australia · Canada - Active not recruitingPHASE1
Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)
This early-stage study is testing a new drug called Tuvusertib (M1774), alone or with another drug called niraparib, for people with advanced solid tumours that have spread or can't be removed by surgery. Doctors want to see if it's safe, how the body handles it, and if it shows any early signs of helping.
For: Metastatic or Locally Advanced Unresectable Solid TumorsUnited States · China · Japan