- Active not recruitingPHASE3
A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
This study is testing a new combination of medicines with chemotherapy for some upper gut cancers that have spread and can't be removed by surgery. It aims to see if the new combination works better than current treatments.
For: Advanced Upper Gastrointestinal Tract AdenocarcinomaUnited States · Argentina · Australia - RecruitingPHASE2
Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLC
This study is for people with advanced lung cancer that has spread. It tests new treatments using a drug called Visugromab, combined with Nivolumab and sometimes Docetaxel, to see if they can work better than existing options.
For: Metastatic Non-Squamous Non-Small Cell Lung Cancer · Adult Solid TumorUnited States · Germany · Italy - RecruitingPHASE2, PHASE3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
This study looks at new drug Pumitamig with chemotherapy, or Nivolumab with chemotherapy, for advanced stomach, gastroesophageal junction, or oesophageal cancer. It aims to see how safe and effective these combinations are for people who haven't had treatment for their advanced cancer.
For: Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal AdenocarcinomaUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
This study is for people with advanced kidney cancer (non-clear cell type) that hasn't spread too widely. It compares a new combination of drugs (XL092 + nivolumab) with a standard treatment (sunitinib) to see which works better. Participants haven't had prior cancer medicine for their advanced kidney cancer.
For: Non-Clear Cell Renal Cell CarcinomaUnited States · Argentina · Australia - RecruitingPHASE4
Cabozantinib and Nivolumab Among Older Patients With Renal Cell Carcinoma
This study looks at how well a treatment combining two drugs, nivolumab and cabozantinib, works for older patients (70 and over) with advanced kidney cancer. It aims to see how patients respond to this treatment in real-life use.
For: Kidney Cancer · Renal Cell CancerFrance - Active not recruitingPHASE1
A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.
This study looks at new drug combinations for advanced melanoma with a specific gene change (NRAS mutation). It tests the safety and effects of belvarafenib, alone or with other medicines, for people who have already tried other treatments.
For: MelanomaUnited States · Australia · Canada - RecruitingPHASE3
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
This study compares a new treatment called IMA203 with standard care for advanced skin melanoma that has already been treated. Its main goal is to see if IMA203 is more effective and safe for patients who have limited treatment options.
For: Melanoma, Cutaneous MalignantUnited States · Canada · France - RecruitingPHASE3
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations
This study is for adults with a certain type of lung cancer (Stage II-IIIB non-small cell lung cancer) that has a specific genetic change (HER2 mutation) and has been fully removed by surgery. It compares a new daily tablet called zongertinib with standard treatments to see if it can stop the cancer from coming back.
For: Non-small Cell Lung CancerUnited States · Argentina · Australia - Active not recruitingPHASE2, PHASE3
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
This study looks at new treatments for advanced eye melanoma that has spread. It compares a combination of two drugs (IDE196 and crizotinib) with standard treatments to see which works best and is safest for patients.
For: Metastatic Uveal MelanomaUnited States · Australia · Belgium - RecruitingPHASE3
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
This study is looking into a new treatment called brenetafusp, combined with nivolumab, for advanced melanoma. We're comparing it to current standard nivolumab treatments to see if it works better for people in the UK whose melanoma hasn't been treated before.
For: Advanced MelanomaUnited States · Argentina · Australia - Active not recruitingPHASE1, PHASE2
A(B)VD Followed by Nivolumab as Frontline Therapy for Higher Risk Patients With Classical Hodgkin Lymphoma (HL)
This study looks at a new drug, Nivolumab, combined with standard treatment (ABVD) for Hodgkin lymphoma. The goal is to improve the chances of a cure, especially for people with higher-risk forms of the disease. It checks if adding Nivolumab helps when initial treatment doesn't fully clear the cancer.
For: Hodgkin LymphomaUnited States · Canada - RecruitingPHASE3
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
This study is testing new combinations of medicines (sonesitatug vedotin, rilvegostomig, and capecitabine) for advanced stomach, gastroesophageal junction, or oesophageal cancers. It aims to see how well they work and if they are safe for people whose cancer has a specific marker called Claudin18.2.
For: Gastric Cancer · Gastroesophageal Junction Adenocarcinoma · Esophageal CancerUnited States · Australia · Austria - RecruitingPHASE1, PHASE2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This study is for children and young people with cancer that hasn't responded to usual treatments. It tests new medicines that target specific changes in cancer cells, aiming to find the right dose and see if they help. The goal is to find better ways to treat childhood cancer.
For: Pediatric CancerDenmark · France · Italy - Active not recruitingPHASE2
Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer
This study looks at new treatments for advanced endometrial cancer that has come back or spread. It tests if combining two drugs, cabozantinib and nivolumab, works better than nivolumab alone to shrink cancer and help people live longer. This could offer new hope for patients.
For: Advanced Endometrial Carcinoma · Metastatic Endometrial Carcinoma · Recurrent Endometrial CarcinomaUnited States · Canada - Active not recruitingPHASE3
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
This study compares a new treatment, Volrustomig combined with standard chemotherapy, against existing treatments for advanced mesothelioma. It aims to see if the new combination is safer and more effective for patients whose cancer can't be removed by surgery.
For: Unresectable Pleural MesotheliomaUnited States · Australia · Belgium - Active not recruitingPHASE3
A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma
This study is testing two new drugs, nivolumab and ipilimumab, together for advanced liver cancer (hepatocellular carcinoma). It compares this combination to standard treatments (sorafenib or lenvatinib) to see if it helps people live longer. Participants haven't had prior treatment.
For: Hepatocellular CarcinomaUnited States · Argentina · Australia - RecruitingPHASE3
Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)
This study looks at the long-term effects of a medicine called belzutifan for people with advanced cancers or cancers linked to Von Hippel-Lindau disease. It's for those already taking belzutifan in other trials. The aim is to see how long people live after starting this treatment.
For: Von Hippel-Lindau Disease · Malignant NeoplasmsUnited States · Australia · Belgium - Active not recruitingPHASE3
Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy
This study looks at a new drug, nivolumab, for kidney cancer that hasn't spread. It compares surgery alone to surgery plus nivolumab to see if the drug can stop the cancer from coming back. It's a phase 3 trial, meaning it's in its later stages of testing.
For: Metastatic Renal Cell Carcinoma · Sarcomatoid Renal Cell Carcinoma · Stage II Renal Cell Cancer AJCC v7United States · Canada · Israel - RecruitingPHASE1
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
This study is looking into a new treatment, BMS-986488, for advanced cancers. Researchers want to see if it's safe, tolerable, and effective, either on its own or with other medicines, for people whose cancer has spread or can't be removed with surgery.
For: Advanced Malignant TumorsUnited States · Australia · Canada - Active not recruitingPHASE3
A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC)
This study looks at new drug combinations for advanced bowel cancer that has spread. It compares nivolumab alone, nivolumab with ipilimumab, and standard chemotherapy to see which works best for patients whose cancer has specific features (dMMR/MSI-H).
For: Metastatic Colorectal CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
Neoadjuvant Nivolumab, or Nivolumab in Combination With Ipilimumab, in Resectable NSCLC
This study looks at new treatments (nivolumab, sometimes with ipilimumab, or nivolumab with chemotherapy) for people with a certain type of lung cancer before surgery. It aims to see if these treatments are safe and how well they work to fight the cancer earlier.
For: Non-Small Cell Lung CancerUnited States · Canada - Active not recruitingPHASE2
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
This study looks at new drug combinations to treat advanced lung cancer. It compares two different drug mixes, each including chemotherapy, to see which works best and is safest for people with Stage IV or recurrent non-small cell lung cancer.
For: Non-small Cell Lung Cancer · Recurrent Non-small Cell Lung Cancer · Metastatic Non-small Cell Lung CancerUnited States · Argentina · Australia - RecruitingPHASE3
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
This study aims to see if a special ultrasound device, Exablate, can help standard cancer medicines work better for people with lung cancer that has spread to the brain. Researchers will compare this new approach to standard care alone.
For: Brain Tumor · Non Small Cell Lung CancerUnited States · Canada · South Korea - RecruitingPHASE2
Nivolumab in Children and Adults With Nasopharyngeal Carcinoma
This study is looking at adding a new drug called Nivolumab to standard chemotherapy for nasopharyngeal cancer. It aims to see if this combination helps more patients achieve a complete response, meaning the cancer is no longer detectable, especially when seen on scans.
For: Nasopharyngeal Carcinoma · Nasopharyngeal Cancer · Nasopharyngeal NeoplasmsGermany - RecruitingPHASE3
The Sagittarius Trial
This study looks at new ways to treat colon cancer after surgery to stop it coming back. It uses advanced tests called 'liquid biopsies' to help doctors choose the best treatment for each person, aiming for better results and fewer side effects.
For: Colon Cancer Stage II · Colon Cancer Stage IIIGermany · Italy · Spain - RecruitingPHASE3
Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated
This study compares a new drug called tepotinib with standard treatments for advanced lung cancer. It's for people whose cancer has a specific change (MET Exon 14 mutation) and has already been treated. The aim is to see if tepotinib works better to stop the cancer from growing.
For: Advanced Non Small Cell Lung Cancer · MET Exon 14 MutationFrance - RecruitingPHASE2
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
This study looks at new ways to treat a rare type of skin cancer called mucosal melanoma, found inside the body. It tests if a drug called nivolumab, alone or with another drug called cabozantinib, can stop the cancer from coming back after surgery or help those where surgery wasn't enough.
For: Anal Melanoma · Bladder Melanoma · Cervical MelanomaUnited States · Canada - AuthorisedTherapeutic use (Phase IV)
Nivolumab dose optimization in patients with a complete, partial or stable response (NIVOPTIMIZE-trial)
This study looks at how different doses of nivolumab, a cancer medicine, work in people with melanoma or kidney cancer. It wants to find the best dose to keep the medicine effective while perhaps using less. This could make treatment easier and more affordable.
For: Melanoma, Renal cell carcinomaNetherlands - Active not recruitingPHASE3
An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
This study looks at a new immune-boosting medicine called Nivolumab for people who have had surgery for bladder or kidney drainage system cancer. It compares Nivolumab to a dummy drug to see if it's safe and helps stop the cancer from coming back.
For: Various Advanced CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
Study of Novel Treatment Combinations in Patients With Lung Cancer
This study looks at new drug combinations to treat lung cancer. It has three parts: for cancer that has spread, cancer that has grown despite previous treatment, and earlier-stage cancer that can be removed by surgery.
For: Lung Cancer · Advanced or Metastatic Non-Small-Cell Lung Cancer · Resectable Non-Small-Cell Lung CancerUnited States · Brazil · Hong Kong - Active not recruitingPHASE2, PHASE3
A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
This study is looking at a new combination of medicines, relatlimab and nivolumab, for advanced melanoma. It aims to see if this combination works better than nivolumab alone for melanoma that has spread or can't be removed by surgery.
For: MelanomaUnited States · Argentina · Australia - Active not recruitingPHASE1, PHASE2
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This study is testing a new drug, BT5528, for advanced cancers like ovarian, lung, and breast cancer. We want to find a safe dose, understand side effects, and see how well it works, sometimes given with another drug called nivolumab.
For: Advanced Solid Tumor Historically Known for High EphA2 Expression · Urothelial Cancer · Ovarian CancerUnited States · Belgium · South Korea - Active not recruitingPHASE3
Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
This study is looking at whether a drug called nivolumab can help prevent melanoma skin cancer from coming back in people who have had surgery to remove it. It compares nivolumab to a dummy treatment (placebo) in adults and children at high risk of their cancer returning.
For: MelanomaUnited States · Australia · Austria - Ongoing, recruitingTherapeutic confirmatory (Phase III)
MOIO_Randomized phase III trial of standard immunotherapy (IO) by checkpoint inhibitors, versus reduced dose intensity of IO in patients with locally advanced or metastatic cancer in response after 6 months of standard IO
This study compares standard immunotherapy with a reduced dose for people whose cancer responded well after 6 months. It looks at how long they stay well and their quality of life. The aim is to see if a lower dose can be just as effective.
For: Only patients with oncologic locally advanced or metastatic tumour (lung cancer · renal cell cancer (except IMDC favorable-risk treated Tyrosine Kinase Inhibitor [TKI] / immunotherapy [IO] combination) · head and neck cancerFrance - Active not recruitingPHASE1
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
This study is testing a new treatment called RP3, alone and with another drug called Nivolumab, for advanced cancers. It aims to find out if RP3 is safe and how much to give for future studies.
For: Advanced Solid TumorUnited States · France · Greece - RecruitingPHASE2, PHASE3
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
This study compares two drug combinations for advanced uveal melanoma. It looks at RP2 with nivolumab versus nivolumab with ipilimumab, for patients who haven't had these immune-boosting treatments before, to see which works better and is safer.
For: Metastatic Uveal MelanomaUnited States · Australia · United Kingdom - Active not recruitingPHASE1
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
This study is testing a new treatment called RP2, alone and with nivolumab, for adults with advanced cancers. It aims to find the safest dose and see how well it works. RP2 is a modified virus designed to fight cancer.
For: CancerSpain · United Kingdom - RecruitingPHASE1
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
This study is testing a new drug, zanzalintinib, alone and with other medicines, for people with advanced cancers like kidney, prostate, and lung cancer. It's looking at safety and if the treatment shrinks tumours.
For: Renal Cell Carcinoma (RCC) · Metastatic Castration-Resistant Prostate Cancer (mCRPC) · Urothelial Carcinoma (UC)United States · Australia · Austria - Active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
This study is looking at a new treatment for a type of bladder cancer called muscle-invasive urothelial carcinoma (MIUC). It combines an experimental medicine, autogene cevumeran, with an existing drug, nivolumab, to see if this combination works better and is safe compared to nivolumab alone.
For: Muscle-invasive Urothelial CarcinomaUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
This study looks at treating muscle-invasive bladder cancer. It compares standard chemotherapy with chemotherapy plus a new immunotherapy drug called nivolumab, given before and after surgery. The aim is to see if adding nivolumab helps more people.
For: Urinary Bladder Neoplasms · Muscle-Invasive Bladder CancerUnited States · Argentina · Australia - Active not recruitingPHASE1
Phase I Study of 131-I mIBG Followed by Nivolumab & Dinutuximab Beta Antibodies in Children With Relapsed/Refractory Neuroblastoma
This study is looking at new ways to treat neuroblastoma in children, a type of cancer. It combines standard treatment with new medicines (Nivolumab and Dinutuximab Beta) to see if they are safe and helpful. The goal is to find better treatments for children whose cancer has come back or is hard to treat.
For: NeuroblastomaUnited States · United Kingdom - RecruitingPHASE2
CD8 PET Imaging in Metastatic Solid Tumours
This study looks at a new type of specialised scan for people with advanced cancer. It uses a small amount of a special substance called 89Zr-Df-crefmirlimab to create detailed pictures. This helps doctors see how well a new cancer treatment, called PD-1 antibody therapy, is working.
For: Locally Advanced Solid TumorNetherlands · Spain · United Kingdom - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.
For: Lung Cancer · Breast CancerUnited States · Australia · Canada - AuthorisedTherapeutic exploratory (Phase II)
IMMUNOPEC: Combination of neo-adjuvant Checkpoint Inhibition and Dendritic Cell Therapy (MesoPher) with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in patients with Peritoneal Mesothelioma
This study is looking at a new combination treatment for peritoneal mesothelioma. It combines existing cancer drugs with a special vaccine, followed by surgery and chemotherapy. The main goal is to see how long patients live without their cancer growing.
For: Peritoneal MesotheliomaNetherlands - RecruitingPHASE1, PHASE2
Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
This study looks at a new drug, mRNA-4359, by itself and with other cancer drugs. It aims to see if it's safe and what side effects it might have in people with advanced solid tumours, which are cancers that have spread.
For: Advanced Solid TumorsUnited States · Australia · Germany - Active not recruitingPHASE3
A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
This study looks at a medicine called nivolumab for liver cancer. It's for people who've had surgery or other treatment to remove their cancer, but are at high risk of it coming back. We want to see if nivolumab can stop the cancer from returning.
For: Hepatocellular Carcinoma · Liver CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Nivolumab Combined With Cabozantinib Compared to Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
This study is testing new combinations of medicines (Nivolumab with Cabozantinib) against a standard treatment (Sunitinib) for kidney cancer that has spread. We want to see if the new combination is safer and works better for people who haven't had treatment before.
For: Renal Cell CarcinomaUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
This study compares new ways to treat advanced lung cancer. It looks at two drug combinations, Nivolumab and Relatlimab plus chemotherapy, versus Pembrolizumab plus chemotherapy. The goal is to find the best treatment for a specific type of lung cancer.
For: Non-small Cell Lung CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
iSCORE: Immunotherapy Sequencing in COlon and REctal Cancer
This study looks at a new combination of immunotherapy (Nivolumab and Relatlimab) for advanced bowel cancer that has spread. It focuses on patients whose cancer stopped responding to previous treatments, hoping to find new options.
For: Metastatic Colorectal CancerUnited Kingdom - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
This study is looking at new ways to treat advanced kidney cancer that hasn't been treated before. It combines three medicines to see if they work better together than two, aiming to help people live longer and keep their cancer from growing.
For: Renal Cell CarcinomaUnited States · Argentina · Australia