- Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
This study looks at a new treatment for a type of breast cancer that has come back or spread. It combines a drug called pembrolizumab with standard chemotherapy to see if it works better than chemotherapy alone for HR+/HER2- breast cancer.
For: Breast NeoplasmsUnited States · Argentina · Australia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Adaptive, Randomized, Controlled Trial Platform to Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections: Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) - Immune Modulation Strategy Trial
This study is looking at new ways to treat adults in hospital with COVID-19. We're testing a medicine called Orencia against a dummy treatment to see if it helps people recover faster and has fewer side effects. It's a big study to find the best care.
For: COVID-19Denmark · France · Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adenoassociated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia.
This study looks at a new gene therapy called Pariglasgene brecaparvovec for people with a rare liver condition called GSDIa. It aims to see if this new treatment can help reduce the amount of cornstarch they need to eat daily to keep their blood sugar stable.
For: Glycogen Storage Disease Type Ia (GSDIa)Denmark · Netherlands · Spain - RecruitingPHASE2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
This study is testing a new medicine, Rhu-pGSN, for people with severe breathing problems (ARDS) caused by infections. It will compare the new medicine to a dummy treatment (placebo) to see if it's safe and helps people recover better.
For: Acute Respiratory Distress Syndrome · InfectionsUnited States · Belgium · Bulgaria