- RecruitingPHASE2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
This study is testing a new medicine, Rhu-pGSN, for people with severe breathing problems (ARDS) caused by infections. It will compare the new medicine to a dummy treatment (placebo) to see if it's safe and helps people recover better.
For: Acute Respiratory Distress Syndrome · InfectionsUnited States · Belgium · Bulgaria - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
This study looks at a new treatment for a type of breast cancer that has come back or spread. It combines a drug called pembrolizumab with standard chemotherapy to see if it works better than chemotherapy alone for HR+/HER2- breast cancer.
For: Breast NeoplasmsUnited States · Argentina · Australia - RecruitingPHASE3
Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain
This study compares two pain medicines, ketorolac and morphine, for children aged 6-17 with belly pain from possible appendicitis. We want to see if ketorolac works just as well as morphine, but with fewer side effects. Both medicines are given through a drip in the arm.
For: Acute Pain · Abdomen, Acute · Abdominal PainCanada - Not yet recruitingPHASE1
A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial)
This study is testing a new vaccine to prevent Hepatitis C. We want to see if it's safe and if it helps your body make "germ fighters" against the virus. It's for healthy adults aged 18-45.
For: Hepatitis CCanada - RecruitingPHASE2
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Researchers are studying if high-dose vitamin C given into the veins, alongside standard chemotherapy for advanced lung cancer, can be helpful. This study will compare vitamin C to a dummy treatment in people with advanced non-small cell lung cancer.
For: Lung CancerCanada - RecruitingPHASE4
CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock
This study looks at whether common heart-boosting medicines, called inotropes (like Dobutamine or Milrinone), truly help very ill patients with a serious heart condition called cardiogenic shock. Researchers will compare these medicines against a dummy treatment (placebo) to see if they are beneficial or potentially harmful.
For: Shock, CardiogenicUnited States · Canada - RecruitingPHASE1
A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria
This study is looking at a new medicine called GTX-B001 for people with constant a particular type of hives called chronic inducible urticaria (like cold hives or hives from scratching). It aims to check if the medicine is safe and if it helps reduce symptoms.
For: Healthy Subjects · Cold Urticaria · Symptomatic DermographismGermany - Active not recruitingPHASE2
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
This study is testing two natural substances, Apelin and Relaxin, to see how they affect blood flow and body processes in people with heart conditions or type 2 diabetes. We want to find new ways to improve health for these conditions.
For: Cardiovascular Diseases · Type 2 Diabetes MellitusUnited Kingdom