- Ongoing, recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
For: CancerSpain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Open-label, multicenter study to evaluate efficacy and safety of ZN-c3 in Adult Women with Recurrent or Persistent Uterine Serous Carcinoma
This study is testing a new medicine, ZN-c3, for women with a type of womb cancer called uterine serous carcinoma that has come back or is still present. It aims to see how well the medicine works and if it has any side effects.
For: recurrent or persistent uterine serous carcinomaSpain · Italy · France - Ongoing, recruitingTherapeutic use (Phase IV)
Randomized trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on recovery after total hip, total knee, and unicompartmental knee arthroplasty
This study compares two types of anaesthesia—spinal and general—for hip and knee replacement surgeries. It aims to see which one helps patients get back on their feet faster, specifically if they can walk 5 metres within 6 hours after surgery.
For: Osteoarthritis of the hip and kneeDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
For: Type 2 DiabetesRomania · Germany · Belgium - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3 Study of Navtemadlin as Maintenance Therapy in Subjects with TP53WT Advanced or Recurrent Endometrial Cancer Who Responded to Chemotherapy
This study looks at a new drug, Navtemadlin, for women with advanced endometrial cancer. It's for those who responded well to previous chemotherapy. The aim is to see if Navtemadlin can help keep the cancer from coming back for longer.
For: Advanced or Recurrent Endometrial CancerLithuania · Estonia · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Experimental hypothermia using cold ambient temperature and drug-induced inhibition of shivering in awake, healthy volunteers: a crossover, double blinded trial
This study looks at how your body responds to cold and how certain medicines might stop you from shivering. Healthy volunteers will have their body temperature carefully lowered and monitored. Researchers want to understand better ways to manage extreme cold, like in emergencies.
For: HypothermiaNorway - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Double-blind, Placebo-controlled, Randomized Withdrawal Study to Evaluate the Efficacy and Safety of SYNB1934 in Patients with PKU (SYNPHENY-3)
This study is testing a new medicine, SYNB1934, for people with Phenylketonuria (PKU). We want to see how well it lowers a substance called phenylalanine (Phe) in the blood and if it's safe to use. It's a key step to potentially making this new treatment available.
For: PhenylketonuriaDenmark - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, adaptive, open-label, single ascending dose to multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-3745 in participants with glycogen storage disease type 1a (GSD1a), followed by an open-label extension
This study is testing a new medicine, mRNA-3745, for Glycogen Storage Disease Type 1a (GSD1a). It's looking at how safe it is, how well people tolerate it, and how it works in the body, starting with low doses and gradually increasing them.
For: Glycogen storage disease type 1a (GSD1a)Spain · Poland · Netherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized, double-blind, Phase 2/3 study of IV amisulpride as prevention of post-operative nausea and vomiting in pediatric patients
This study looks at a new medicine, amisulpride, to see if it can stop children from feeling sick or being sick after an operation. It compares it with other common medicines to see how well it works and if it's safe.
For: post-operative nausea and vomiting in pediatric patientsFrance · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of Co-administration of AZD9550 and AZD6234 in Participants Living With Obesity or Overweight with Comorbidity
This study is looking at a new combination of medicines (AZD9550 and AZD6234) for people who are overweight or have obesity and other health problems. Researchers want to see if these medicines help with weight loss and if they are safe to use.
For: Investigating obesity or overweight condition correlated to many co-morbiditiesGermany - AuthorisedTherapeutic confirmatory (Phase III)
Postoperative recovery with the addition of long-acting NK1- and 5-HT3 receptor antagonists as prophylaxis for post-operative nausea and vomiting. A prospective, double-blind, randomized trial in laparoscopic surgery.
This study is looking at new ways to prevent sickness and vomiting after stomach surgery. It tests different medicines to see which ones help patients recover better and feel less sick after their operation. The goal is to make recovery an easier experience for people.
For: Post-operative nausea and vomiting (PONV)Sweden - AuthorisedTherapeutic exploratory (Phase II)
J2R-MC-YAAD: A Phase 2, Double-blind, Placebo-Controlled Study to Evaluate LY3537021 for the Treatment of Chemotherapy-Induced Nausea and Vomiting in Adult Participants With Malignant Disease
This study is looking into a new medicine called LY3537021 (also known as Lagipra) to help prevent sickness and vomiting caused by chemotherapy. It compares the new medicine to a dummy pill (placebo) and other common anti-sickness treatments in adults having cancer treatment.
For: Drug-Related Side Effects and Adverse Reactions · Nausea · NeoplasmsRomania · Spain · France