- Ongoing, recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
For: CancerSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase I/II Open-label, Multi-center Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD7789, an anti-PD-1 and anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma
This study is looking at a new medicine for people in the UK with Hodgkin Lymphoma that has come back or hasn't responded to other treatments. It aims to check if the new medicine, AZD7789, is safe, what effects it has, and if it helps in treating the cancer.
For: Relapsed/Refractory Classical Hodgkin LymphomaItaly · Denmark · Spain - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
An open-label, first-in-human, dose-escalation/expansion study of SAR443579 administered as single agent by intravenous infusion in adult and pediatric participants with relapsed or refractory acute myeloid leukemia (R/R AML), B-cell acute lymphoblastic leukemia (B-ALL), high risk-myelodysplasia (HR-MDS), or blastic plasmacytoid dendritic cell neoplasm (BPDCN)
This study is testing a new medicine called SAR443579 for adults and children with certain types of blood cancers that haven't responded to other treatments. It aims to find the right dose and see how well it works and if it's safe.
For: Acute lymphocytic leukaemia- Acute myeloid leukaemia refractory - Myelodysplastic syndrome - Blastic plasmacytoid dendritic cell neoplasiaFrance · Netherlands - Active not recruitingPHASE1, PHASE2
Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants
This study is testing a new vaccine to protect children, toddlers, and babies against meningococcal disease. Researchers want to see if the new vaccine is safe and works well compared to existing vaccines, sometimes given alongside other routine childhood shots.
For: Meningococcal Immunization · Healthy VolunteersBrazil · Czechia · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, two-arm, placebo-controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritis
This study is looking into a new medicine, DFV890, for people with knee osteoarthritis. It compares DFV890 to a dummy treatment (placebo) to see if it helps with pain and is safe to use.
For: Knee OsteoarthritisGermany · Spain · Hungary - Ongoing, recruitingTherapeutic exploratory (Phase II)
Multicenter, double-blind, randomized, placebo-controlled, dose-response trial with the full-spectrum Cannabis Extract VER-01 in patients with chronic non-specific low back pain
This study is testing a new cannabis-based medicine, VER-01, for people with ongoing lower back pain. It will compare VER-01 to a dummy pill (placebo) to see if it helps reduce pain when other pain medicines haven't worked or can't be used. We want to know if it's safe and effective.
Germany · Czechia · Spain - Ongoing, recruitingPhase III and phase IV (Integrated)
A study in healthy volunteers to improve methods for detection of GHB in drug rape victims
This study looks for better ways to detect the drug GHB in people, especially if it's used to harm someone. Researchers want to find new clues in blood, pee, and hair to show when someone has taken GHB, even days later. This could help victims and investigations.
For: IntoxicationDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Randomized trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on recovery after total hip, total knee, and unicompartmental knee arthroplasty
This study compares two types of anaesthesia—spinal and general—for hip and knee replacement surgeries. It aims to see which one helps patients get back on their feet faster, specifically if they can walk 5 metres within 6 hours after surgery.
For: Osteoarthritis of the hip and kneeDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Exploratory study evaluating the relevance of [68Ga]Ga-PentixaFor for initial staging and detection of minimal residual disease in multiple myeloma patients eligible for autologous stem cell transplantation less than 66 years included in the prospective IFM 2020-02.
This study looks at a new type of scan, called [68Ga]Ga-PentixaFor, for people under 66 with multiple myeloma. It checks how well this scan finds the cancer when first diagnosed and helps track if any cancer cells remain after treatment.
For: Multiple MyelomaFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic pain due to central Neuropathy of any Genesis
This study is looking into a new spray (AP707) for people with long-term pain caused by nerve damage. It compares the spray to a dummy spray to see if it helps reduce pain over time. We want to know if it's safe and effective.
For: Chronic pain due to central Neuropathy of any GenesisAustria · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with Chronic Back Pain
This study is looking at a new cannabis-based medicine called AP707 for people with ongoing back pain. Researchers want to see if it helps reduce pain better than a dummy treatment and how well people tolerate it.
For: Chronic back painGermany · Austria - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic Pain due to traumatic or post-operative peripheral Neuropathy
This study is looking at a new spray (AP707) for chronic pain caused by nerve damage after an injury or surgery. It aims to see how well it works and if it has side effects, compared to a dummy spray, for adults aged 18 and over.
For: Chronic Pain due to traumatic or post-operative peripheral NeuropathyGermany · Austria - Ongoing, recruitingTherapeutic exploratory (Phase II)
A parallel-group treatment, proof-of-concept Phase 2, multicenter, double-blind, randomized 2 arm clinical trial to investigate the efficacy and safety of subcutaneous NT 201 injections compared with placebo injections in decreasing pain intensity in male and female participants aged 18 years and older with moderate or severe chronic neuropathic pain due to postherpetic neuralgia or peripheral nerve injury.
This study is looking into a new injection treatment for adults with ongoing nerve pain caused by shingles or nerve damage. It wants to see if the injection, called NT 201, can make the pain less severe and if it's safe to use compared to a dummy injection.
For: Moderate to severe chronic peripheral neuropathic pain (PNP) due to postherpetic neuralgia (PHN) or peripheral nerve injury.Germany · Bulgaria · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic Pain due to Diabetic Polyneuropathy
This study is looking for new ways to help people with ongoing pain caused by diabetes affecting their nerves. It's testing a new spray treatment to see if it reduces pain and if it's safe compared to a dummy spray.
For: Chronic pain due to diabetic polyneuropathyAustria · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A PHASE 2 MULTICENTER STUDY OF AXICABTAGENE CILOLEUCEL IN SUBJECTS WITH RELAPSED/REFRACTORY INDOLENT NON-HODGKIN LYMPHOMA (INHL)
This study looks at a new type of cell therapy, Yescarta, for people with certain types of slow-growing non-Hodgkin lymphoma that has come back or hasn't responded to other treatments. Researchers are checking how well it works and if it's safe over many years.
For: Follicular Lymphoma · Marginal Zone Lymphoma · Indolent Non-Hodgkin LymphomaFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
For: Rheumatoid ArthritisGermany · Poland · Hungary - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2a, Open-label, Dose Escalation Trial of GEN3017 with Expansion Cohorts in Relapsed or Refractory CD30+ Classical Hodgkin Lymphoma and CD30+ Non-Hodgkin Lymphoma
This study is testing a new medicine called GEN3017 for people with Hodgkin or non-Hodgkin lymphoma. It's an early-stage trial looking at safe doses and checking for side effects, as well as seeing how well the treatment shrinks the cancer.
For: Hodgkin lymphoma or non-Hodgkin lymphomaGermany · Denmark · Italy - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First in-Human, Consecutive-Cohort, Clinical Trial of BI 1910, a Monoclonal Antibody to Tumor Necrosis Factor Receptor 2 (TNFR2), as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors
This study is testing a new drug, BI 1910, for people with advanced cancers. It will check how safe the drug is, what side effects it causes, and how much of it the body can handle, both on its own and when given with another cancer drug.
For: Advanced solid tumorsDenmark · Poland · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, two-arm, placebo-controlled, participant, investigator and sponsor-blinded, proof-of-concept study investigating the efficacy, safety and tolerability of QUC398 in patients with symptomatic knee osteoarthritis
This study is testing a new medicine, QUC398, for people with knee osteoarthritis. We want to see if it helps reduce pain and is safe to use. Patients will receive either QUC398 or a dummy treatment, along with standard pain relief.
For: Knee osteoarthritisDenmark · Spain · France - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, adaptive, open-label, single ascending dose to multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-3745 in participants with glycogen storage disease type 1a (GSD1a), followed by an open-label extension
This study is testing a new medicine, mRNA-3745, for Glycogen Storage Disease Type 1a (GSD1a). It's looking at how safe it is, how well people tolerate it, and how it works in the body, starting with low doses and gradually increasing them.
For: Glycogen storage disease type 1a (GSD1a)Spain · Poland · Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Perioperative oral analgesia versus intravenous analgesia for knee arthroscopy, a randomized, double-blinded, non-inferiority trial. OVIKA-trial - S68618
This study, called OVIKA, is looking at the best way to manage pain after a common knee operation. Researchers are comparing pain relief given through an IV drip with pain relief given as tablets to see if tablets work just as well for knee pain.
For: Postoperative pain relief after knee arthroscopyBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase I-II, First-in-Human Study of SKB264 in Patients with Locally Advanced Unresectable /Metastatic Solid Tumors Who are Refractory to Available Standard Therapies
This study is testing a new medicine called SKB264 for people with advanced solid tumours that haven't responded to other treatments. It's a first step to see how safe and effective SKB264 is, and to understand its effects on the body.
For: Metastatic or locally advanced unresectable solid tumors progressing after available standard therapiesSpain · Italy - AuthorisedTherapeutic exploratory (Phase II)
A multi-center single arm Phase II study to evaluate the safety and efficacy of genetically engineered autologous cells expressing anti-CD20 and anti-CD19 specific chimeric antigen receptor in subjects with relapsed and/or refractory diffuse large B cell lymphoma
This study looks at a new type of cell therapy, called MB-CART2019.1, for people with a specific type of lymphoma that has come back or hasn't responded to other treatments. It checks how safe and effective it is.
For: Relapsed/refractory diffuse large B cell lymphoma (R-R DLBCL)Hungary · Croatia - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of mRNA 3210 in Participants with Phenylketonuria
This study is testing a new messenger RNA (mRNA) medicine called mRNA-3210 for people with Phenylketonuria (PKU). Researchers want to see if it's safe, how much of it stays in the body, and how it affects PKU. It's an early-stage study, meaning it's one of the first times it's being given to humans.
For: Participants with PhenylketonuriaFrance · Spain · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An open label, multi-centric trial to assess the safety and efficacy of an Esflurbiprofen Topical System (EFTS) in the local symptomatic and short-term treatment of pain in contusions.
This study is testing a new sticky patch (Esflurbiprofen Topical System) for treating pain from bruises. Researchers want to see how safe and effective it is compared to paracetamol for short-term pain relief in adults.
For: acute contusion of the upper or lower limbsGermany - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Nitrous oxide detection - A study in healthy volunteers to help victims of nitrous oxide related crimes
This study looks at how long 'laughing gas' (nitrous oxide) stays in the body after someone has breathed it in. It's done with healthy volunteers to help identify its use in crimes by improving detection methods.
For: Nitrous oxide intoxicationDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of an Esflurbiprofen Topical System (EFTS) vs. placebo in the local symptomatic and short-term treatment of pain in ankle sprains.
This study is testing a patch for ankle sprains to see if it reduces pain better than a dummy patch or paracetamol. It's for adults with mild sprains, and we'll compare pain levels and safety.
For: Acute ankle sprains grade IGermany - Ongoing, recruitingTherapeutic exploratory (Phase II)
Randomized, multi-center, double-blind, two-armed, parallel active groups, prospective trial, to evaluate, in pediatric population undergoing 'Calcaneo stop' surgery or Inguinal hernia repair, the efficacy and safety of chloroprocaine 1% and 2% for peripheral nerve block based on concentration-response relationships.
This study is looking at how well two different strengths of a medicine called chloroprocaine work to numb pain during common childhood surgeries, like `Calcaneo stop` or hernia repair. We want to find the best and safest dose for children.
For: Calcagno stop and inguinal hernia repairItaly - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
For: Rheumatoid arthritisPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-Finding Study to Evaluate the Safety, Tolerability, Preliminary Efficacy and Pharmacokinetics of iN1011-N17-02 in Patients with Post herpetic Neuralgia (PHN)
This study is testing a new medicine, iN1011-N17-02, for nerve pain after shingles. It aims to see if it's safe, how well it works, and what dose is best, compared to a dummy pill or other pain relief.
For: Post herpetic NeuralgiaPoland · Bulgaria - AuthorisedTherapeutic exploratory (Phase II)
The HIt HArd and hiT early in multiple sclerosis trial – HiHat trial
This study, called HiHat, is looking into new treatments for relapsing-remitting multiple sclerosis (MS) in people who have had the condition for less than 10 years. It's investigating if certain medicines can stop MS from getting worse, while making sure they are safe.
For: Patients with relapsing-remitting multiple sclerosis with less than 10 years disease duration.Sweden - AuthorisedTherapeutic use (Phase IV)
Erector Spinae Plane Block for acute low back pain: a prospective double-blind randomized multicenter study. ESP-BACK
Researchers are looking into whether a new injection called an Erector Spinae Plane Block can help people with sudden, severe lower back pain feel better quickly. They want to see if it reduces pain and helps people move easier soon after the injection, compared to usual treatments.
For: Acute low back painFrance