- RecruitingPHASE1
A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants
This study looks at how a new medicine, pelabresib, interacts with two common drugs, phenytoin and itraconazole, in healthy people. We want to understand how these drugs affect pelabresib's levels in the body and check for safety.
For: Healthy ParticipantsUnited Kingdom - RecruitingPHASE1
Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment
This study looks at a new drug, pelabresib, for people with advanced cancers and liver problems. We want to see how the drug works in the body and if it's safe for those with different levels of liver health.
For: Advanced Malignancies and Hepatic ImpairmentFrance · Italy · Spain - Active not recruitingPHASE3
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
This study is testing a new medicine called pelabresib alongside an existing treatment (ruxolitinib) for adults with myelofibrosis who haven't tried similar drugs before. It aims to see if this combination works better than ruxolitinib alone to help manage symptoms and spleen size.
For: Myelofibrosis · Primary Myelofibrosis · Post-polycythemia Vera MyelofibrosisUnited States · Australia · Austria - RecruitingPHASE3
An Extension Study for Patients Previously Enrolled in Studies With Pelabresib
This study looks at the continued safety and benefit of a medicine called pelabresib for people with blood or solid cancers. It's for those who have used pelabresib before in other studies.
For: Hematologic Malignancy · Solid Tumor · Advanced MalignanciesUnited States · Belgium · Italy