- Active not recruitingPHASE3
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
This study is testing a new tablet medicine called etavopivat for people aged 12 to 65 with sickle cell disease. It aims to see if the medicine can improve a patient's red blood cells and reduce painful sickle cell crises. Half the group will receive the new treatment, the other a placebo.
For: Sickle Cell DiseaseUnited States · Canada · Egypt - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of the NOX1/4 Inhibitor Setanaxib in Patients with Alport Syndrome
This study is testing a new medicine, Setanaxib, for Alport syndrome. We want to see if it's safe, how it works in the body, and if it helps reduce kidney damage and other symptoms. Half the participants will get the new medicine, and half will get a dummy pill.
For: Alport syndromeSpain · Czechia · France - AuthorisedTherapeutic use (Phase IV)
Antibiotic treatment following surgical drainage of perianal abscess: a double-blind, placebo-controlled, randomized trial
This study looks at whether antibiotics after surgery for a perianal abscess can stop a new problem called a fistula forming within a year. Participants will receive either different antibiotics or a dummy pill (placebo) to see which, if any, helps. It's for adults with a perianal abscess.
For: Perianal abscessNetherlands - Active not recruitingPHASE2
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
This study is testing a new medicine, bezuclastinib, for people with certain types of mastocytosis (a rare blood disorder). It compares bezuclastinib with a dummy pill (placebo) to see if it safely helps reduce symptoms that aren't well controlled by current treatments.
For: SSM · Mastocytosis, Indolent · Mastocytosis, SystemicUnited States · Australia · Belgium