- RecruitingPHASE3
Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis
This study looks at a new way to treat bowel inflammation (colitis) caused by cancer medicines called immune checkpoint inhibitors. It compares standard steroids with steroids plus a drug called infliximab to see which works best and fastest.
For: ColitisDenmark · United Kingdom - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pressurised MDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (KALOS)
This study is testing a new inhaler for adults with asthma that isn't well controlled. It compares a new triple-medicine inhaler to existing ones to see if it works better at preventing asthma attacks and improving breathing over 24-52 weeks.
For: Severe and inadequately controlled asthmaSpain · Romania · Hungary - Ongoing, recruitingTherapeutic use (Phase IV)
Transfer of prednisolone into human breast milk and plasma of breastfeeding children - A low intervention cohort study with biobanking of breast milk and plasma
This study looks at how much prednisolone medication, taken by breastfeeding mums, passes into their breast milk and then into their baby's blood. We want to understand if babies are exposed to the medicine and how much.
For: Reumatoid Arthritis · SLE · myositisSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pMDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (LOGOS)
This study is looking at new inhalers for adults with asthma that isn't well-controlled. It aims to see if a new combination inhaler works better than current ones to improve breathing and reduce asthma attacks.
For: Severe and inadequately controlled asthmaPortugal · Greece · Germany - RecruitingPHASE2
A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome
This study is testing a new drug, acalabrutinib, alongside the usual treatment (CHOP-R) for Richter's Syndrome. It aims to see if this combination improves outcomes for people recently diagnosed with this aggressive blood cancer.
For: Richter SyndromeUnited Kingdom - RecruitingPHASE2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
This study compares two treatments for a fast-growing blood cancer called diffuse large B-cell lymphoma (DLBCL), specifically a type called GCB DLBCL. Researchers want to see if a new drug, zilovertamab vedotin, when combined with standard therapy, works better than another combination in shrinking the cancer.
For: Lymphoma, Large B-Cell, DiffuseUnited States · Belgium · Germany - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
This study is testing a new drug, Farletuzumab Ecteribulin, for certain advanced cancers like ovarian, endometrial, and some breast and lung cancers. Researchers want to see if it's safe, how well it works, and find the best dose.
For: Solid TumorUnited States · France · Japan - RecruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
For: Prostate Cancer · Metastatic Castration-Resistant Prostate Cancer · Metastatic Hormone Sensitive Prostate CancerUnited States · China · France - RecruitingPHASE3
High Dose Steroids in Children With Stroke
This study looks at whether strong anti-inflammatory medicines (steroids) can help children recover from a type of stroke called focal cerebral arteriopathy (FCA). Scientists want to see if steroids, given alongside standard care, lead to better and faster recovery.
For: Paediatric StrokeAustralia · Austria · Denmark - Ongoing, recruitingPhase II and Phase III (Integrated)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients with Bullous Pemphigoid
This study is testing a new medicine, Dupixent, for a skin condition called Bullous Pemphigoid. We want to see if it helps heal the skin and reduce itching better than current treatments, looking at how safe and effective it is for adults.
For: Bullous PemphigoidFrance · Poland · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Safety and Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy B – Relapsed/Refractory Richter Transformation (RT)
This study looks at a new cell therapy called Tecartus for adults with a type of blood cancer called Richter Transformation that has come back or not responded to previous treatments. It aims to see how well it works and if it's safe.
For: Relapsed/refractory Richter Transformation (RT)France · Germany · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Efficacy of Brexucabtagene Autoleucel in Adults with Rare B-cell Malignancies (ZUMA 25) – Substudy C – Relapsed/Refractory Burkitt Lymphoma (BL)
This study is looking at a new treatment called Tecartus for adults in the UK with a specific type of blood cancer called Burkitt Lymphoma. It's for patients whose cancer has come back or hasn't responded to previous treatments. Researchers want to see how well Tecartus works.
For: Relapsed/Refractory Burkitt Lymphoma (BL)Netherlands · France · Austria - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 open-label, controlled, randomised, multi-centre trial comparing imlifidase and standard-of-care with standard-of-care alone in the treatment of severe anti-GBM antibody disease (Goodpasture disease)
This study is testing a new medicine, Idefirix, for a rare kidney disease called Goodpasture disease. Researchers want to see if Idefirix, along with usual care, helps kidney function better than usual care alone over six months.
For: Anti-GBM antibody disease (Goodpasture disease)Spain · Czechia · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SPR001 (Tildacerfont) in Reducing Supraphysiologic Glucocorticoid Use in Adult Subjects with Classic Congenital Adrenal Hyperplasia
This study is looking into a new medication called Tildacerfont for adults with a condition called classic congenital adrenal hyperplasia. It aims to see if Tildacerfont can help reduce the amount of steroid medicine (like hydrocortisone or prednisolone) people need to take.
For: Classic Congenital Adrenal HyperplasiaSweden · Netherlands · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-Week, Phase 2 Open-Label, Sequential Dose Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 Treatment in Participants with Congenital Adrenal Hyperplasia
This study is looking at a new treatment called CRN04894 for people with Congenital Adrenal Hyperplasia (CAH). It will check if the treatment is safe, how well it works, and how the body handles it. This is an early-stage study.
For: CONGENITAL ADRENAL HYPERPLASIAGermany · Italy - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2a, Open-label, Dose Escalation Trial of GEN3017 with Expansion Cohorts in Relapsed or Refractory CD30+ Classical Hodgkin Lymphoma and CD30+ Non-Hodgkin Lymphoma
This study is testing a new medicine called GEN3017 for people with Hodgkin or non-Hodgkin lymphoma. It's an early-stage trial looking at safe doses and checking for side effects, as well as seeing how well the treatment shrinks the cancer.
For: Hodgkin lymphoma or non-Hodgkin lymphomaGermany · Denmark · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, ADAPTIVE PHASE III TRIAL TO INVESTIGATE EFFICACY AND SAFETY OF VILOBELIMAB IN THE TREATMENT OF ULCERATIVE PYODERMA GANGRENOSUM
This study is testing a new medicine called Gohibic for people with a skin condition called ulcerative pyoderma gangrenosum. It compares Gohibic to other treatments or a dummy medicine to see if it helps heal the ulcers and reduces pain, with the aim of finding better ways to treat this condition.
For: ulcerative pyoderma gangrenosumBelgium · Hungary · Poland - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase I/II, open-label, dose escalation study to evaluate the safety of 2 doses of intravenous ATA-200, an adeno-associated viral vector carrying the human gamma-sarcoglycan gene, in patients with gamma-sarcoglycanopathy (limb-girdle muscular dystrophy LGMDR5, formerly LGMD2C).
This study is testing a new gene therapy for a rare muscle condition called limb-girdle muscular dystrophy type R5 (LGMD-R5). It aims to see if the treatment is safe, what dose works best, and if it helps improve muscle function.
For: limb-girdle muscular dystrophy type R5 (previously named LGMD2C)France · Italy - AuthorisedTherapeutic confirmatory (Phase III)
High Dose Steroids in Children with Stroke and Unilateral Focal Arteriopathy: A Multicentre Randomized Controlled Trial
This study looks at using strong steroid medicines to treat a type of stroke in children called focal cerebral arteriopathy (FCA). Researchers want to see if these medicines can reduce the inflammation in blood vessels and improve children's recovery.
For: Focal cerebral arteriopathy and childhood stroke Focal cerebral arteriopathy (FCA) is an inflammatory vessel wall disease provoked by infection.France · Austria · Germany - Ongoing, recruitingTherapeutic use (Phase IV)
Pragmatic, randomized, multicentric, double-blind, controlled clinicial trial on the treatment of acute gout attacks with prednisolone versus colchicine in primary care (COPAGO)
This study compares two common treatments, prednisolone and colchicine, for sudden attacks of gout. It aims to find out which medicine works better for pain relief and other symptoms in people experiencing a gout flare-up, using a safe and unbiased approach.
For: gout · acute gout attackGermany - AuthorisedTherapeutic use (Phase IV)
A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis to compare active conventional therapy versus three biologic treatments, and two de-escalation strategies in patients who respond to treatment.
This study looks at different ways to treat early rheumatoid arthritis, comparing standard treatments with newer biologic medicines. It also explores if medicine doses can be lowered for people who are getting better, aiming to find the most effective and safe long-term approaches.
For: Rheumatoid ArthritisIceland · Denmark · Norway - Active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
For: Prostate CancerSwitzerland · United Kingdom - Active not recruitingPHASE3
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
This study is testing a new medicine, Belumosudil, alongside standard steroids for people aged 12 and over newly diagnosed with chronic Graft-versus-Host Disease (cGVHD). We want to see if this combination works better to manage the condition.
For: Chronic Graft Versus Host DiseaseUnited States · Argentina · Australia - AuthorisedTherapeutic use (Phase IV)
Safety and efficacy of steering of immunosuppression based on BKPyV-specific T cells in case of BK Polyomavirus (BKPyV) DNAe- mia after kidney transplantation
This study looks at how well a new approach to adjusting medicines helps control a common virus called BK Polyomavirus (BKPyV) in people who have had a kidney transplant. The goal is to find the best way to keep the new kidney healthy.
For: BK Polyomavirus DNAemia after kidney transplantationGermany - AuthorisedTherapeutic exploratory (Phase II)
BOSICART - Bosentan in the treatment of Giant Cell Arteritis
This study called BOSICART is looking at a new medicine, Bosentan, for Giant Cell Arteritis. It aims to see if Bosentan can help patients reduce their steroid dose without their condition coming back, improving their health and well-being.
For: Newly diagnosed or relapsing Giant-cell arteritisFrance - AuthorisedTherapeutic confirmatory (Phase III)
A prospective, open-label, randomized, multicenter phase-III trial to evaluate the efficacy of pirtobrutinib and epcoritamab compared with R-(mini)-CHOP for treatment of patients with Richter Transformation - CLLRT2
This study compares new drug combinations (pirtobrutinib and epcoritamab) with standard treatment for a type of lymphoma called Richter Transformation. It aims to see if the new treatments stop the cancer from growing for longer. Participants will get either the new drugs or standard chemotherapy.
For: previously untreated RT · irrespective of risk factors and disease stageAustria · Germany · Denmark