- Active not recruitingPHASE3
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
This study is looking at a new combination of medicines for men with advanced prostate cancer that has stopped responding to standard hormone therapy. It aims to see if adding a drug called apalutamide to current treatment helps men live longer without their cancer getting worse.
For: Prostatic NeoplasmsUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
This study looks at a new drug, pasritamig, with docetaxel to see if it helps men with advanced prostate cancer live longer without their cancer growing. It compares this combination to docetaxel alone.
For: Prostatic Neoplasms, Castration-ResistantUnited States · Australia · Belgium - RecruitingPHASE2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
This study compares two treatments for a fast-growing blood cancer called diffuse large B-cell lymphoma (DLBCL), specifically a type called GCB DLBCL. Researchers want to see if a new drug, zilovertamab vedotin, when combined with standard therapy, works better than another combination in shrinking the cancer.
For: Lymphoma, Large B-Cell, DiffuseUnited States · Belgium · Germany - RecruitingPHASE3
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This study is testing a new medicine, Opevesostat, for men with prostate cancer that has spread and is resistant to hormone treatment. We want to see if Opevesostat helps men live longer compared to standard hormone therapies, especially after they've had other treatments.
For: Prostate Cancer MetastaticUnited States · Argentina · Australia - Active not recruitingPHASE3
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
This study compares a new treatment, axicabtagene ciloleucel, with standard care for adults recently diagnosed with high-risk large B-cell lymphoma. It aims to see if the new treatment works better as a first treatment option.
For: High-risk Large B-cell Lymphoma (LBCL)United States · Australia · Austria - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
This study is testing a new treatment, LY3884961, for babies with a serious inherited condition called Type 2 Gaucher disease. Researchers want to see if it's safe and effective. It's a long-term study, following babies for up to 5 years.
For: Gaucher Disease, Type 2United States · United Kingdom - Active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
This study looks at a new drug, golcadomide, combined with standard treatment for follicular lymphoma that's been recently diagnosed and is advanced. We want to see how well this new combination works and if it's safe for patients.
For: Lymphoma, FollicularUnited States · Australia · Brazil - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
This study is testing a new drug, Farletuzumab Ecteribulin, for certain advanced cancers like ovarian, endometrial, and some breast and lung cancers. Researchers want to see if it's safe, how well it works, and find the best dose.
For: Solid TumorUnited States · France · Japan - Active not recruitingPHASE1
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This study is testing new ways to give medicines called niraparib and abiraterone acetate for men with advanced prostate cancer. Researchers want to see how well different forms of these drugs are absorbed by the body to help patients get the best treatment.
For: Prostatic NeoplasmsUnited States · Belgium · France - RecruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
For: Prostate Cancer · Metastatic Castration-Resistant Prostate Cancer · Metastatic Hormone Sensitive Prostate CancerUnited States · China · France - Active not recruitingPHASE3
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
This study is looking at a new treatment combination for a type of blood cancer called Diffuse Large B-cell Lymphoma (DLBCL). It combines a new drug, tafasitamab, and another drug, lenalidomide, with standard chemotherapy to see if it works better than chemotherapy alone.
For: Diffuse Large B-cell LymphomaUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
This study is looking at a new treatment called axicabtagene ciloleucel for follicular lymphoma that has come back or hasn't responded to other treatments. It compares this new treatment to standard care to see how well it works.
For: Relapsed/Refractory Follicular LymphomaUnited States · France · Germany - Active not recruitingPHASE1
A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer
This study is looking at a new prostate cancer drug, JNJ-56021927, alongside existing treatments like abiraterone acetate and prednisone. Researchers want to see if these drugs work well together, check for side effects, and find the best doses for future studies in men with advanced prostate cancer.
For: Prostatic Neoplasms · Metastatic Castration-Resistant Prostate CancerUnited States · Canada · Netherlands - RecruitingPHASE1, PHASE2
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
This study is testing new treatments for advanced prostate cancer that has spread and no longer responds to hormone therapy. It aims to see how safe and effective a new drug, Opevesostat, is when given alone or with other medicines to men with this condition.
For: Prostatic Neoplasms, Castration-ResistantUnited States · Australia · Canada - Active not recruitingPHASE3
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
This study is looking at a new treatment called glofitamab for a type of cancer called large B-cell lymphoma. It compares this new treatment, along with other medicines, against a standard treatment for people who haven't had treatment before.
For: Large B-Cell LymphomaUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.
For: Kidney Transplant RejectionAustralia · Chile · China - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, parallel-group, double-blind, placebo-controlled, multicenter Phase III trial to evaluate efficacy and safety of secukinumab administered subcutaneously versus placebo, in combination with a glucocorticoid taper regimen, in patients with polymyalgia rheumatica (PMR)
This study is testing a new medicine, secukinumab, for polymyalgia rheumatica (PMR). It compares secukinumab with a dummy treatment (placebo) alongside a common steroid medicine to see if it helps reduce symptoms and allows people to use less steroid medicine.
For: Polymyalgia RheumaticaDenmark · Italy · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Trial of Nivolumab Plus Ipilimumab, Ipilimumab Alone, or Cabazitaxel in Men with Metastatic Castration-Resistant Prostate Cancer
This study looks at new drug combinations for men with advanced prostate cancer that has stopped responding to hormone therapy. It compares different treatments to see which works best at shrinking tumours and slowing cancer growth.
For: Metastatic Castration-Resistant Prostate CancerGermany - Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2 Study of Pembrolizumab and Chemotherapy in Patients With Newly Diagnosed Classical Hodgkin Lymphoma (KEYNOTE-C11)
This study looks at a new treatment called pembrolizumab, combined with standard chemotherapy, for adults recently diagnosed with classical Hodgkin lymphoma. Researchers want to see how many patients go into complete remission at the end of the treatment plan.
For: Classical Hodgkin LymphomaFrance · Poland · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER, ADAPTIVE PHASE III TRIAL TO INVESTIGATE EFFICACY AND SAFETY OF VILOBELIMAB IN THE TREATMENT OF ULCERATIVE PYODERMA GANGRENOSUM
This study is testing a new medicine called Gohibic for people with a skin condition called ulcerative pyoderma gangrenosum. It compares Gohibic to other treatments or a dummy medicine to see if it helps heal the ulcers and reduces pain, with the aim of finding better ways to treat this condition.
For: ulcerative pyoderma gangrenosumBelgium · Hungary · Poland - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study is looking into a new medicine, efgartigimod, for people with bullous pemphigoid (BP). It compares efgartigimod to a dummy drug (placebo) to see if it can help patients achieve clear skin without needing steroid tablets for a long time.
For: Bullous Pemphigoid (BP)Czechia · Italy · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy
This study looks at a medicine called Entyvio for children and teenagers with moderate to severe ulcerative colitis. It aims to see if Entyvio helps them stay in remission (when symptoms improve or disappear) and if it's safe to use over time.
For: Moderately to severely active Ulcerative Colitis (UC)Greece · Croatia · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, parallel-group, double-blind, placebo-controlled, multicenter Phase III trial to investigate the efficacy and safety of secukinumab 300 mg and 150 mg administered subcutaneously versus placebo, in combination with a glucocorticoid taper regimen, in patients with giant cell arteritis (GCA) (GCAptAIN)
This study is testing a new medicine, secukinumab, for giant cell arteritis (GCA). It compares different doses of secukinumab with a dummy medicine (placebo), alongside a common steroid treatment. The aim is to see if secukinumab can help people with GCA stay well for longer.
For: Giant cell arteritis (GCA)Estonia · Sweden · Hungary - AuthorisedTherapeutic exploratory (Phase II)
A Phase II Open Label Study of Brentuximab Vedotin in Combination with CHEP in Patients with Previously Untreated CD30-expressing Peripheral T-cell Lymphomas (PTCL)
This study is looking at a new combination of medicines, including Brentuximab Vedotin (Adcetris), for adults with a type of cancer called CD30-expressing Peripheral T-cell Lymphoma (PTCL) that hasn't been treated before. We want to see how well this new treatment shrinks the cancer.
For: CancerCzechia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A prospective multicenter phase 2 study of copanlisib in combination with rituximab and CHOP chemotherapy (COPA-R-CHOP) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL)
This study looks at a new drug, BAY 80-6946, with standard chemotherapy for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It's in an early stage (Phase 2), focusing on finding the best dose and checking if the treatment is safe and effective.
For: Diffuse large B-cell lymphoma (DLBCL)Germany - AuthorisedTherapeutic confirmatory (Phase III)
Early start corticosteroids versus standard care (RASBs followed by corticosteroids) for proteinuria in Immunoglobulin A Nephropathy (IgAN) patients with active renal lesions identified by kidney biopsy and RASBs combined with corticosteroids versus sodium-glucose cotransporter2 inhibitor combined with RASBs for proteinuria and renal function in IgAN patients with chronic renal lesions identified by kidney biopsy. A PROJECT FOR TWO MULTICENTRE, PROSPECTIVE OPEN LABEL RANDOMIZED CLINICAL STUDIES TO EVALUATE THE EFFECT OF TARGETED THERAPY BASED ON KIDNEY BIOPSY FINDINGS IN IgAN PATIENTS (CLIgAN)
This study is looking at new ways to treat IgA nephropathy (IgAN), a kidney disease. It compares different medications like steroids and dapagliflozin to see how well they reduce protein in the urine and protect kidney function in people with IgAN, depending on their kidney biopsy results.
For: Idiopathic IgA nephropathy (IgAN)Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
HD21 for advanced stages - Treatment optimization trial in the first-line treatment of advanced stage Hodgkin lymphoma; comparison of 4-6 cycles of escalated BEACOPP with 4-6 cycles of BrECADD
This study compares two common treatments for advanced Hodgkin lymphoma (a type of cancer). It looks at how well they work, their side effects, and their impact on quality of life, especially for older patients.
For: Advanced Stage of Hodgkin LymphomaNorway · Austria · Netherlands - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
This study is looking at a new treatment for men with prostate cancer that has spread and is responding to hormone therapy. It combines a drug called niraparib with standard treatments (abiraterone acetate and prednisone) to see if it works better for those with specific genetic changes.
For: Metastatic Castration-sensitive Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - RecruitingPHASE3
A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
This study is looking at new ways to prevent a serious bleeding condition in babies called FNAIT. It compares a new medicine, nipocalimab, with standard treatments like IVIG, in pregnant women who have had FNAIT before. The aim is to find safer, more effective ways to protect newborns.
For: Thrombocytopenia, Neonatal AlloimmuneUnited States · Austria · Germany - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
This study looks at a new combination of drugs, cabozantinib and atezolizumab, for men with prostate cancer that has spread and is no longer responding to hormone therapy. It compares this new combination with standard hormone treatments to see if it works better.
For: Metastatic Prostate Cancer · Prostate AdenocarcinomaUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
This study is testing a new combination of medicines, niraparib and abiraterone, with prednisone, for men with advanced prostate cancer that has spread and is resistant to hormone therapy. It compares this new combination against the standard treatment of abiraterone and prednisone to see if it works better.
For: Castration-Resistant Prostatic CancerUnited States · Argentina · Australia - RecruitingPHASE3
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
This study is looking at a new drug, epcoritamab, combined with standard treatments for follicular lymphoma, a type of blood cancer. We want to see if this combination is safe and effective in people who haven't been treated for this condition before.
For: Follicular Lymphoma (FL)United States · Australia · Belgium - Active not recruitingPHASE3
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
This study is testing a new medicine, Belumosudil, alongside standard steroids for people aged 12 and over newly diagnosed with chronic Graft-versus-Host Disease (cGVHD). We want to see if this combination works better to manage the condition.
For: Chronic Graft Versus Host DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
This study is looking into a new drug, epcoritamab, for people with a type of blood cancer called Diffuse Large B-cell Lymphoma (DLBCL). It compares epcoritamab combined with standard treatment (R-CHOP) to R-CHOP alone, to see if the new combination works better.
For: Diffuse Large B-Cell LymphomaUnited States · Australia · Austria - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
For: Lupus NephritisUnited States · Argentina · Brazil - AuthorisedTherapeutic exploratory (Phase II)
BOSICART - Bosentan in the treatment of Giant Cell Arteritis
This study called BOSICART is looking at a new medicine, Bosentan, for Giant Cell Arteritis. It aims to see if Bosentan can help patients reduce their steroid dose without their condition coming back, improving their health and well-being.
For: Newly diagnosed or relapsing Giant-cell arteritisFrance - RecruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
For: Prostate Cancer · Prostatic NeoplasmsUnited States · Argentina · Australia - RecruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
For: Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE2
Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy
The REFRACT trial explores new treatments for follicular lymphoma that has come back or not responded to previous therapy. It compares new drugs with standard care to see if they offer better results for patients.
For: Relapsed Follicular Lymphoma · Refractory Follicular LymphomaUnited Kingdom