Quality-of-Life Assessment clinical trials
21 indexed studies · 7 currently recruiting
- Active not recruitingPHASE3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This study looks at the best treatment for women with a common type of early breast cancer. It compares hormone therapy alone against hormone therapy plus chemotherapy, using a special test to help decide which is best for each woman.
For: Breast Adenocarcinoma · Hormone Receptor Positive · Stage IA Breast Cancer AJCC v7United States · Australia · Canada - RecruitingPHASE2
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This study looks at combining nivolumab, an immunotherapy drug, with chemotherapy and then radiation for young people with nasopharyngeal cancer. Researchers want to see if this new treatment can fight the cancer effectively, understand its side effects, and potentially reduce radiation for children.
For: Stage II Nasopharyngeal Carcinoma AJCC v8 · Stage III Nasopharyngeal Carcinoma AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Canada · New Zealand - RecruitingPHASE3
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
This study compares keyhole surgery (minimally invasive surgery) with traditional open surgery (laparotomy) for advanced ovarian cancer. It's for women who've already had chemotherapy. The aim is to see if keyhole surgery is as good or better for recovery and quality of life.
For: Advanced Ovarian Carcinoma · Fallopian Tube Clear Cell Adenocarcinoma · Fallopian Tube Endometrioid TumorUnited States · Canada · Italy - Active not recruitingPHASE3
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
This study compares two immunotherapy drugs (nivolumab or brentuximab vedotin) when used with chemotherapy for newly diagnosed, advanced Hodgkin lymphoma. It aims to see which combination works best at shrinking the cancer and keeping it away.
For: Ann Arbor Stage III Hodgkin Lymphoma · Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma · Ann Arbor Stage III Mixed Cellularity Classic Hodgkin LymphomaUnited States · Canada · Puerto Rico - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - Active not recruitingPHASE3
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
This study looks at two medicines, T-DM1 and tucatinib, to see if combining them is better than T-DM1 alone at stopping high-risk HER2-positive breast cancer from coming back. It focuses on people who still have some cancer cells after their first treatment.
For: Anatomic Stage IA Breast Cancer AJCC v8 · Anatomic Stage II Breast Cancer AJCC v8 · Anatomic Stage IIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - Active not recruitingPHASE3
Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
This study compares two ways of giving radiation after brain cancer surgery. It's for people whose cancer has spread to the brain from elsewhere. We want to see if giving radiation in several small doses is better than one large dose for preventing cancer from coming back and improving quality of life.
For: Metastatic Malignant Neoplasm in the BrainUnited States · Canada - Active not recruitingPHASE3
Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia
This study is for young people with a type of leukaemia called APL. It tests if a treatment combining two drugs, tretinoin and arsenic trioxide, can work as well as standard chemotherapy, but with fewer long-term side effects, especially for the heart.
For: Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARAUnited States · Australia · Canada - Active not recruiting
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma
This study looks at how neuroblastoma treatment affects children and young adults years later. We want to understand these long-term effects to help improve future treatments and quality of life for survivors.
For: Recurrent Neuroblastoma · Stage 2A Neuroblastoma · Stage 2B NeuroblastomaUnited States · Australia · Canada - Active not recruitingPHASE2, PHASE3
Individualized Treatment Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
This study looks at new ways to treat nasopharyngeal cancer, a type of head and neck cancer. It focuses on using a blood test for the Epstein-Barr virus (EBV) to decide the best treatment after initial therapy. We want to see if different drug combinations improve outcomes.
For: Epstein-Barr Virus Infection · Stage II Nasopharyngeal Carcinoma · Stage III Nasopharyngeal CarcinomaUnited States · Australia · Canada - Recruiting
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This study looks at the long-term health of children and young people who have had retinoblastoma, a type of eye cancer. By collecting information, samples, and doing eye tests, doctors hope to better understand the cancer, its treatments, and how it affects patients over time.
For: Retinoblastoma · Cancer Survivor · Biological SiblingUnited States · Canada - RecruitingPHASE3
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
This study looks at whether some people with early triple-negative breast cancer who had a good response to initial treatment can skip further immunotherapy after surgery. It compares continuing pembrolizumab with just being watched closely to see if both approaches are equally good at preventing cancer from coming back.
For: Anatomic Stage II Breast Cancer AJCC v8 · Early Stage Triple-Negative Breast Carcinoma · Anatomic Stage IIIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - RecruitingPHASE3
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
This study compares two ways to give radiation therapy for high-risk prostate cancer. One uses fewer, stronger treatments (SBRT), and the other is the usual longer course. We want to see if the shorter treatment works just as well to stop the cancer from coming back.
For: Prostate Adenocarcinoma · Stage III Prostate Cancer AJCC v8 · Stage IVA Prostate Cancer AJCC v8United States · Canada · Hong Kong - Active not recruitingPHASE3
Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer
This study compares two types of radiation treatment, SBRT and IMRT, for men with early-stage prostate cancer. It looks at which treatment causes fewer side effects and is better at keeping the cancer away. Your quality of life is a key focus.
For: Stage II Prostate Adenocarcinoma AJCC v7United States · Canada · Hong Kong - Active not recruitingPHASE3
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
This study compares a new drug, selumetinib, with a standard treatment (carboplatin/vincristine) for children and young people aged 2-21 with a type of brain tumour called low-grade glioma, linked to Neurofibromatosis Type 1. It aims to see if the new drug is as effective and especially if it improves vision.
For: Low Grade Glioma · Neurofibromatosis Type 1 · Visual Pathway GliomaUnited States · Canada · Puerto Rico - RecruitingPHASE3
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
This study compares watchful waiting with radiation therapy for people who have had a common type of brain tumour called grade 2 meningioma completely removed. It aims to see if radiation after surgery helps prevent the tumour from returning.
For: Grade 2 Meningioma · Intracranial MeningiomaUnited States · Canada · India - Active not recruitingPHASE3
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
This study compares two ways of giving radiation therapy after breast cancer surgery. It's for women with certain types of stage 2 or 3 breast cancer who have had a mastectomy. The aim is to see if a shorter, stronger radiation treatment is as good, or better, at stopping cancer from coming back.
For: Ductal Breast Carcinoma · Invasive Breast Carcinoma · Lobular Breast CarcinomaUnited States · Canada - Active not recruitingPHASE3
Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy
This study looks at a new drug, nivolumab, for kidney cancer that hasn't spread. It compares surgery alone to surgery plus nivolumab to see if the drug can stop the cancer from coming back. It's a phase 3 trial, meaning it's in its later stages of testing.
For: Metastatic Renal Cell Carcinoma · Sarcomatoid Renal Cell Carcinoma · Stage II Renal Cell Cancer AJCC v7United States · Canada · Israel - Active not recruitingPHASE3
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
This study is testing if adding an immunotherapy drug called pembrolizumab to standard chemotherapy (paclitaxel and carboplatin) works better for advanced or returning womb cancer. It aims to see if this new combination helps patients more than chemotherapy alone.
For: Endometrial Clear Cell Adenocarcinoma · Endometrial Dedifferentiated Carcinoma · Endometrial Endometrioid AdenocarcinomaUnited States · Canada · Japan - Active not recruiting
Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy
This study looks at how young children with a type of brain tumour called ependymoma respond to standard chemotherapy. It also checks for long-term side effects to help doctors improve treatment for them in the future.
For: Brain and Central Nervous System Tumors · Cognitive/Functional Effects · Long-term Effects Secondary to Cancer Therapy in ChildrenUnited Kingdom - RecruitingNA
Focal Therapy for Prostate Cancer Using HIFU
This study is looking at an advanced treatment called 'focal therapy' using HIFU for prostate cancer. It aims to see how well it controls cancer while reducing side effects like erection problems and bladder issues, which are common with other treatments.
For: Male Erectile Disorder · Prostate Cancer · Therapy-related ToxicityUnited Kingdom