Questionnaire Administration clinical trials
21 indexed studies · 9 currently recruiting
- RecruitingPHASE3
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
This study looks at how best to treat a type of cancer called germ cell tumours in children and adults. It compares simply watching the tumour after surgery with different chemotherapy treatments to see which works best and causes fewer side effects.
For: Childhood Extracranial Germ Cell Tumor · Extragonadal Embryonal Carcinoma · Germ Cell TumorUnited States · Australia · Canada - RecruitingPHASE2
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This study looks at combining nivolumab, an immunotherapy drug, with chemotherapy and then radiation for young people with nasopharyngeal cancer. Researchers want to see if this new treatment can fight the cancer effectively, understand its side effects, and potentially reduce radiation for children.
For: Stage II Nasopharyngeal Carcinoma AJCC v8 · Stage III Nasopharyngeal Carcinoma AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Canada · New Zealand - RecruitingPHASE3
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
This study compares keyhole surgery (minimally invasive surgery) with traditional open surgery (laparotomy) for advanced ovarian cancer. It's for women who've already had chemotherapy. The aim is to see if keyhole surgery is as good or better for recovery and quality of life.
For: Advanced Ovarian Carcinoma · Fallopian Tube Clear Cell Adenocarcinoma · Fallopian Tube Endometrioid TumorUnited States · Canada · Italy - Active not recruitingPHASE3
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
This study compares two immunotherapy drugs (nivolumab or brentuximab vedotin) when used with chemotherapy for newly diagnosed, advanced Hodgkin lymphoma. It aims to see which combination works best at shrinking the cancer and keeping it away.
For: Ann Arbor Stage III Hodgkin Lymphoma · Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma · Ann Arbor Stage III Mixed Cellularity Classic Hodgkin LymphomaUnited States · Canada · Puerto Rico - Active not recruitingPHASE2
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This study looks at whether a daily low-dose aspirin can stop Barrett's oesophagus from coming back after successful treatment. We're also checking how safe aspirin is and tracking specific body markers that might show if the condition is returning.
For: Barrett Esophagus · Esophageal AdenocarcinomaUnited States · Canada - Active not recruitingPHASE3
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
This study looks at new ways to treat a type of cancer called rhabdomyosarcoma. It compares standard chemotherapy with chemotherapy plus a drug called temsirolimus, for patients whose cancer has an average chance of coming back. Researchers want to see if adding temsirolimus helps more.
For: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE3
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
This study looks at two medicines, T-DM1 and tucatinib, to see if combining them is better than T-DM1 alone at stopping high-risk HER2-positive breast cancer from coming back. It focuses on people who still have some cancer cells after their first treatment.
For: Anatomic Stage IA Breast Cancer AJCC v8 · Anatomic Stage II Breast Cancer AJCC v8 · Anatomic Stage IIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - Active not recruitingPHASE3
Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
This study compares two ways of giving radiation after brain cancer surgery. It's for people whose cancer has spread to the brain from elsewhere. We want to see if giving radiation in several small doses is better than one large dose for preventing cancer from coming back and improving quality of life.
For: Metastatic Malignant Neoplasm in the BrainUnited States · Canada - Active not recruitingPHASE3
Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia
This study is for young people with a type of leukaemia called APL. It tests if a treatment combining two drugs, tretinoin and arsenic trioxide, can work as well as standard chemotherapy, but with fewer long-term side effects, especially for the heart.
For: Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARAUnited States · Australia · Canada - Recruiting
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This study looks at the long-term health of children and young people who have had retinoblastoma, a type of eye cancer. By collecting information, samples, and doing eye tests, doctors hope to better understand the cancer, its treatments, and how it affects patients over time.
For: Retinoblastoma · Cancer Survivor · Biological SiblingUnited States · Canada - RecruitingPHASE2
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
This study looks at treating children and young adults with a type of brain tumour called germinoma. Researchers want to see if using a lower dose of radiation therapy after chemotherapy can work just as well, but with fewer long-term side effects.
For: Basal Ganglia Germinoma · Diabetes Insipidus · GerminomaUnited States · Australia · Canada - RecruitingPHASE3
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
This study looks at whether some people with early triple-negative breast cancer who had a good response to initial treatment can skip further immunotherapy after surgery. It compares continuing pembrolizumab with just being watched closely to see if both approaches are equally good at preventing cancer from coming back.
For: Anatomic Stage II Breast Cancer AJCC v8 · Early Stage Triple-Negative Breast Carcinoma · Anatomic Stage IIIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - RecruitingPHASE3
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
This study compares two ways to give radiation therapy for high-risk prostate cancer. One uses fewer, stronger treatments (SBRT), and the other is the usual longer course. We want to see if the shorter treatment works just as well to stop the cancer from coming back.
For: Prostate Adenocarcinoma · Stage III Prostate Cancer AJCC v8 · Stage IVA Prostate Cancer AJCC v8United States · Canada · Hong Kong - Active not recruitingPHASE3
Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer
This study compares two types of radiation treatment, SBRT and IMRT, for men with early-stage prostate cancer. It looks at which treatment causes fewer side effects and is better at keeping the cancer away. Your quality of life is a key focus.
For: Stage II Prostate Adenocarcinoma AJCC v7United States · Canada · Hong Kong - Active not recruitingPHASE3
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
This study compares a new drug, selumetinib, with a standard treatment (carboplatin/vincristine) for children and young people aged 2-21 with a type of brain tumour called low-grade glioma, linked to Neurofibromatosis Type 1. It aims to see if the new drug is as effective and especially if it improves vision.
For: Low Grade Glioma · Neurofibromatosis Type 1 · Visual Pathway GliomaUnited States · Canada · Puerto Rico - RecruitingPHASE3
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
This study compares two types of lung surgery for osteosarcoma that has spread to the lungs. It aims to see if traditional open surgery is better than a keyhole approach for removing cancerous spots. This is a Phase 3 trial, meaning it's a key step in finding the best treatment.
For: Metastatic Malignant Neoplasm in the Lung · Metastatic Osteosarcoma · OsteosarcomaUnited States · Australia · Canada - Active not recruitingPHASE3
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
This study compares two ways of giving radiation therapy after breast cancer surgery. It's for women with certain types of stage 2 or 3 breast cancer who have had a mastectomy. The aim is to see if a shorter, stronger radiation treatment is as good, or better, at stopping cancer from coming back.
For: Ductal Breast Carcinoma · Invasive Breast Carcinoma · Lobular Breast CarcinomaUnited States · Canada - Active not recruitingPHASE3
Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy
This study looks at a new drug, nivolumab, for kidney cancer that hasn't spread. It compares surgery alone to surgery plus nivolumab to see if the drug can stop the cancer from coming back. It's a phase 3 trial, meaning it's in its later stages of testing.
For: Metastatic Renal Cell Carcinoma · Sarcomatoid Renal Cell Carcinoma · Stage II Renal Cell Cancer AJCC v7United States · Canada · Israel - Active not recruitingPHASE3
Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial
This study compares adding radiation to usual care for cancer patients with high-risk bone growths that aren't painful. It aims to see if this helps prevent problems like bone breaks better than usual care alone.
For: Metastatic Malignant Neoplasm in the Bone · Metastatic Malignant Solid NeoplasmUnited States · Canada - Active not recruitingPHASE3
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
This study is testing if adding an immunotherapy drug called pembrolizumab to standard chemotherapy (paclitaxel and carboplatin) works better for advanced or returning womb cancer. It aims to see if this new combination helps patients more than chemotherapy alone.
For: Endometrial Clear Cell Adenocarcinoma · Endometrial Dedifferentiated Carcinoma · Endometrial Endometrioid AdenocarcinomaUnited States · Canada · Japan - RecruitingNA
Focal Therapy for Prostate Cancer Using HIFU
This study is looking at an advanced treatment called 'focal therapy' using HIFU for prostate cancer. It aims to see how well it controls cancer while reducing side effects like erection problems and bladder issues, which are common with other treatments.
For: Male Erectile Disorder · Prostate Cancer · Therapy-related ToxicityUnited Kingdom