- RecruitingNA
Reproductive Hormones During Sustained Administration of Kisspeptin
This study looks at how a hormone called kisspeptin affects other hormones (LH, FSH, testosterone, oestradiol) linked to fertility. We test different doses of kisspeptin or a dummy treatment over 8 days each month, for four months, to understand its effects.
For: Fertility Disorders · Hypothalamic DysfunctionUnited Kingdom - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
This study is looking at a new treatment for a type of bladder cancer called muscle-invasive urothelial carcinoma (MIUC). It combines an experimental medicine, autogene cevumeran, with an existing drug, nivolumab, to see if this combination works better and is safe compared to nivolumab alone.
For: Muscle-invasive Urothelial CarcinomaUnited States · Argentina · Australia - RecruitingNA
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
This study looks at how people's lungs respond to a harmless mist that acts like a virus. It aims to understand lung inflammation better, especially in people with asthma, to help develop new treatments for respiratory infections without causing actual illness.
For: Innate Immunity · Mucosal Immunity · AsthmaUnited Kingdom - Ongoing, recruitingTherapeutic exploratory (Phase II)
Does the Glucagon-like Peptide 1 (GLP-1) receptor agonist semaglutide reduce alcohol intake in patients with Alcohol Use Disorder and comorbid obesity?
This study is looking into whether a medicine called semaglutide, which is usually for diabetes and weight loss, can help people with alcohol use disorder who also have obesity to drink less alcohol. It's an early-stage study to see if it works.
For: Alcohol Use DisorderDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Pilot study RCT anti-NGF Adalimumab versus placebo in fasciotomy Dupuytren contracture
This study is testing a new medicine called Adalimumab for Dupuytren's disease, a hand condition. Researchers want to see if this medicine can help straighten fingers better than a dummy treatment after surgery. The main goal is to improve finger movement by at least 10 degrees.
For: Dupuytren DiseaseBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
For: Rheumatoid ArthritisGermany · Poland · Hungary - Ongoing, recruitingTherapeutic exploratory (Phase II)
Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)
This study, called COPD-LIVE, is looking at whether common vaccines might help the body's natural defense system in people with long-term lung disease (COPD). It aims to see if specific vaccines can reduce inflammation and improve health over time.
For: Chronic obstructive pulmonary diseaseDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
NAPO - Novel Approach for Oligospermia
This study, called NAPO, is looking into how a new medicine called Prolia might help men with male infertility, specifically those with a low sperm count. Researchers will compare Prolia to a dummy treatment to see if it improves sperm concentration.
For: Male infertilityDenmark - AuthorisedTherapeutic exploratory (Phase II)
Local Antibiotic Delivery for Community Acquired Pneumonia (LANDCAP 2)
This study is looking at new ways to treat pneumonia, a serious chest infection. We want to see if delivering antibiotics directly to the lungs, or using different antibiotics, helps people recover faster and spend less time in hospital. It's a key step in finding better treatments.
For: Community-acquired pneumoniaDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-blind, Placebo-Controlled, Phase 2 Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous TAK-341 in Subjects With Multiple System Atrophy
This study is testing a new medicine, TAK-341, for Multiple System Atrophy (MSA). Researchers want to see if it's safe, and if it can help improve symptoms of MSA over 52 weeks, compared to a dummy treatment.
For: Multiple System AtrophyDenmark · Italy · Portugal - AuthorisedTherapeutic confirmatory (Phase III)
Phase III Randomized, Double-Blind Clinical Trial to Determine the Role of Magnesium Sulfate in Adductor Canal Block in Total Knee Arthroplasty
This study looks at whether adding a special salt called magnesium sulfate to a pain-blocking injection (adductor canal block) helps people having knee replacement surgery. The aim is to see if it makes the pain relief last longer, meaning fewer strong painkillers are needed.
For: Total knee arthroplastySpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Effects of a single denosumab injection on reduction of total contact cast treatment and consolidation of bone fractures caused by acute Charcot foot in patients with diabetes mellitus (CHARCOT study)
This study looks at how a single injection of a medicine called denosumab might help people with diabetes who have a foot condition called Charcot foot. It wants to see if this injection can help broken bones in the foot heal faster and reduce the time someone needs to wear a special boot.
For: Charcot · diabetesNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
A blinded randomized study of ephedrine 0.15 mg/kg for reducing onset time of rocuronium 0.6 mg/kg in elderly patients (≥ 80 years)
This study is looking at whether a medicine called ephedrine can help a muscle relaxant called rocuronium work faster in elderly patients (80 years or older) undergoing planned surgery. We want to see if ephedrine helps patients get ready for surgery more quickly.
For: Elective surgeryDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Given Concurrently with Platinum-based Chemoradiation Therapy in Patients with Locally Advanced, Unresectable Non-small Cell Lung Cancer (Stage III) (PACIFIC2)
This study looks at a new drug called Imfinzi for people with a type of lung cancer that has spread nearby but can't be removed by surgery. It aims to see if Imfinzi, along with standard treatments like chemotherapy and radiation, helps people live longer and keeps the cancer from growing.
For: Patients with Locally Advanced · Unresectable Non-small Cell Lung Cancer (Stage III)Poland · Hungary - Not yet recruitingNA
Nebulised Hypertonic Saline to Decrease Respiratory Exacerbations in Neuromuscular Disease or Neurodisability
This study looks at whether breathing in salty water (hypertonic saline) can help people with certain muscle or brain conditions avoid frequent chest infections. Participants will use a nebuliser twice a day for a year to see if this treatment reduces the need for antibiotics.
For: Neuromuscular Diseases · Neurodevelopmental Disorders · Cerebral PalsyUnited Kingdom - AuthorisedTherapeutic exploratory (Phase II)
Autologous Bone Marrow derived cells for the treatment of chronic arterial Limb Ischemia in patients with high risk of amputation
This study looks at using a person's own bone marrow cells to help people with severe leg circulation problems. The aim is to see if these cells can help improve blood flow, reduce pain, heal wounds, and potentially save a leg from amputation.
For: advanced chronic ischemia (fontaine III-IV class and Rutherford IV-V) · with risk of amputation of at least one limbSpain - AuthorisedTherapeutic use (Phase IV)
COPD-2VAX: Enhancing Protection Against Respiratory Infections Through AS01-Mediated Innate Immune Activation in High-Risk Patients
This study looks at how new vaccines for lung conditions and common infections work in people with COPD. It aims to see if these vaccines can help their body's defenses (immune system) fight off respiratory illnesses better.
For: Chronic Obstructive Pulmonary Disease (COPD)Denmark