- Active not recruitingPHASE2, PHASE3
A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)
This study looks at a new treatment called sepofarsen for a rare eye condition called Leber Congenital Amaurosis 10 (LCA10), which causes blindness. We want to see if it helps improve sight, how safe it is, and how well people tolerate it.
For: Leber Congenital Amaurosis 10 · Blindness · Leber Congenital AmaurosisUnited States · Belgium · Brazil - RecruitingPHASE2
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
This study is testing a new eye drop and an injection for a common cause of vision loss called Geographic Atrophy (GA), linked to Age-related Macular Degeneration (AMD). It aims to see how well these treatments work and if they are safe for people aged 55 and over.
For: Geographic Atrophy (GA) · Age - Related Macular Degeneration (AMD)United States · Austria · Canada - RecruitingNA
Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population
This study looks at using gentle electrical brain stimulation with brain exercises to help people with dementia. Researchers want to find the best way to do this to improve memory and thinking skills. They will also use special tests to see how the brain changes.
For: DementiaCanada - RecruitingPHASE4
Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization
This study looks at whether a blood-thinning medicine called heparin can help people who have had a finger or toe reattached after an injury. Researchers want to see if heparin makes the reattachment more successful and what side effects it might cause.
For: Amputation; Traumatic, HandCanada - RecruitingNA
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study looks at how anxiety and anhedonia (loss of pleasure) affect how people react to rewards and threats. It also checks if a gentle electrical stimulation (tVNS) to a nerve in your neck can help. It involves online tasks, brain scans, and virtual reality games.
For: Healthy Participants · Anxiety Disorders (With High Anxiety Symptoms) · Depressive Disorders (With High Anhedonia Symptoms)Germany - Active not recruitingNA
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women with Recurrent Urinary Tract Infections
This study looks into whether a special laser treatment inside the vagina can help women after menopause who keep getting urinary tract infections (UTIs). It compares the laser to a dummy treatment to see if it makes a difference and helps improve vaginal health.
For: Recurrent Urinary Tract Infection · Genitourinary Syndrome of MenopauseUnited Kingdom