- Ongoing, recruitingTherapeutic exploratory (Phase II)
A 4-Week, Phase II, Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel Group Study With 2 Weeks of Follow-Up to Evaluate Safety and Efficacy of Two Different Dosages of Isocyclosporin A Eye Drop Solution Versus Vehicle in Adult Patients with Atopic Keratoconjunctivitis (AKC).
This study is testing a new eye drop called Isocyclosporin A for adults with a severe allergic eye condition called Atopic Keratoconjunctivitis (AKC). It aims to see if the drops can reduce itchy eyes and are safe to use.
For: Atopic keratoconjunctivitis (AKC)Italy - Ongoing, recruitingTherapeutic exploratory (Phase II)
KAN-101-03: A Phase 2a Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of KAN-101 In Participants With Celiac Disease
This study is testing a new medicine, KAN-101, for people with coeliac disease. It wants to see if the medicine can help the gut lining heal and reduce symptoms, and if it's safe to use. Patients will receive either the medicine or a dummy treatment.
For: celiac diseaseFinland · Ireland · Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 4-Week, Phase II, Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel Group Study With 4 Weeks of Follow-Up to Evaluate Safety and Efficacy of a new formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution at two different Concentrations in patients with Dry Eye Disease (REDUCO study)
This study is testing a new eye drop for dry eye disease. It uses a man-made version of a natural body substance to see if it improves dry eye symptoms and overall eye health over 8 weeks, with a follow-up period.
For: Dry EyeItaly - Ongoing, recruitingTherapeutic use (Phase IV)
Treatment of vascular stiffness in patients with autosomal dominant polycystic kidney disease
This study is looking at ways to improve blood vessel health in people with Polycystic Kidney Disease (ADPKD). It compares a high-salt diet to a potato starch placebo and tests a common medication called amiloride to see how it affects blood vessel stiffness.
For: Autosomal Dominant Polycystic Kidney DiseaseNetherlands - Not yet recruitingPHASE2
Prevent Cognitive Decline in GBA-associated Parkinson's Disease
This study is testing a new medicine called prasinezumab to see if it can slow down memory and thinking problems in people with Parkinson's disease who have a specific genetic change. It involves monthly infusions over two years.
For: Parkinson's DiseaseFrance · Germany · Italy - RecruitingPHASE3
Personalized Long-term Human Albumin Treatment in Patients With Decompensated Cirrhosis and Ascites
This study looks at a new way to treat liver scarring (cirrhosis) and fluid build-up (ascites). It tests if a special blood test can predict who will benefit most from regular albumin infusions, aiming to give effective treatment to the right patients.
For: Decompensated Cirrhosis and AscitesBelgium · Denmark · Germany - Ongoing, recruitingPhase III and phase IV (Integrated)
A study in healthy volunteers to improve methods for detection of GHB in drug rape victims
This study looks for better ways to detect the drug GHB in people, especially if it's used to harm someone. Researchers want to find new clues in blood, pee, and hair to show when someone has taken GHB, even days later. This could help victims and investigations.
For: IntoxicationDenmark - Ongoing, recruitingTherapeutic use (Phase IV)
Randomized trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on recovery after total hip, total knee, and unicompartmental knee arthroplasty
This study compares two types of anaesthesia—spinal and general—for hip and knee replacement surgeries. It aims to see which one helps patients get back on their feet faster, specifically if they can walk 5 metres within 6 hours after surgery.
For: Osteoarthritis of the hip and kneeDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
J1A-MC-KDAF: A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, peresolimab, for adults with moderate to severe rheumatoid arthritis. It aims to see if the medicine can reduce arthritis symptoms, like joint pain and swelling, better than a dummy treatment.
For: Rheumatoid Arthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Connective Tissue Diseases Autoimmune Diseases Immune System DiseasesHungary · Spain · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I5T-MC-AACQ: Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults with Early Symptomatic Alzheimer’s Disease
This study is looking at how different amounts of the drug donanemab affect swelling in the brain (ARIA-E) and reduce amyloid — a protein linked to Alzheimer's disease. It's for adults in the early stages of Alzheimer's.
For: Neurocognitive Disorders · Central Nervous System Diseases · Neurodegenerative DiseasesItaly - Ongoing, recruitingTherapeutic exploratory (Phase II)
Experimental hypothermia using cold ambient temperature and drug-induced inhibition of shivering in awake, healthy volunteers: a crossover, double blinded trial
This study looks at how your body responds to cold and how certain medicines might stop you from shivering. Healthy volunteers will have their body temperature carefully lowered and monitored. Researchers want to understand better ways to manage extreme cold, like in emergencies.
For: HypothermiaNorway - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Hypercholesterolemia
This study is looking at a new medicine, MK-0616, for adults with high cholesterol. It compares the new medicine to a dummy pill to see if it lowers 'bad' cholesterol and how safe it is over 24 weeks. This helps us understand if MK-0616 could be a new treatment option.
For: HypercholesterolemiaItaly · Spain · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess the Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects with Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) Allergy
This study is testing a new injection called PURETHAL Mites to see if it can help adults with hay fever-like symptoms or asthma caused by house dust mites. It compares the injection to a dummy treatment (placebo) to see if it reduces their allergy symptoms.
For: Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis with or without Asthma Induced by House Dust Mite (HDM) AllergyLithuania · Germany · Latvia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase 2, randomised, double-blind, placebo-controlled trial to evaluate safety and local tolerability of four weekly administrations of A24110He in subjects with elevated triglyceride plasma concentrations
This study is testing a new medicine called A24110He for people with very high levels of a type of fat (triglycerides) in their blood. We want to see if it's safe and how the body handles it. Participants will receive either the new medicine or a dummy treatment (placebo).
For: Moderate to severe hypertriglyceridemiaSweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, double-dummy, multicenter, multinational study to assess the efficacy and safety of orally administered tebipenem pivoxil hydrobromide (TBP-PI-HBr) compared to intravenously (IV) administered imipenem-cilastatin in patients with complicated urinary tract infection (cUTI) or acute pyelonephritis (AP)
This study is looking at a new tablet treatment for serious urinary tract infections (UTIs) and kidney infections. It compares this new tablet with a standard IV (into the vein) treatment to see if it's safe and works well.
For: complicated urinary tract infection (cUTI) or acute pyelonephritis (AP)Latvia · Poland · Estonia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-masked, placebo-controlled safety, tolerability, and efficacy study of VRDN-001, a humanized monoclonal antibody directed against the IGF-1 receptor, in participants with chronic thyroid eye disease (TED)
This study is testing a new medicine, VRDN-001, for people with an eye condition called Thyroid Eye Disease (TED). Researchers want to see if it's safe, if it helps improve eye bulging and other symptoms, and how well people tolerate it.
For: Thyroid eye diseaseSpain · Hungary · Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS) KEYNOTE-091
This study looks at a drug called Keytruda after surgery for a type of lung cancer. It aims to see if Keytruda can stop the cancer from coming back for longer than a dummy treatment in patients with non-small cell lung cancer, especially those with certain cancer markers.
For: Stage IB (T ≥ 4 cm) · II and IIIA NSCLCSpain · Denmark · Czechia - AuthorisedTherapeutic exploratory (Phase II)
Local Antibiotic Delivery for Community Acquired Pneumonia (LANDCAP 2)
This study is looking at new ways to treat pneumonia, a serious chest infection. We want to see if delivering antibiotics directly to the lungs, or using different antibiotics, helps people recover faster and spend less time in hospital. It's a key step in finding better treatments.
For: Community-acquired pneumoniaDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase I/III Randomized, Double-blind Study to Evaluate the Safety, Efficacy, and Neutralizing Activity of AZD5156/AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants with Conditions Causing Immune Impairment
This study is testing a new medicine, Sipavibart (also called AZD5156/AZD3152), to see if it can prevent COVID-19 in people with weaker immune systems. It compares the new medicine to an existing one called Evusheld or a dummy treatment, focusing on how safe and effective it is.
For: COVID-19Spain · France · Germany - AuthorisedTherapeutic confirmatory (Phase III)
Glutamate infusion for prevention of Acute Kidney Injury in surgery for ischemic heart disease: (GLUTAMICS III = GLUTAmate for Metabolic Intervention in Coronary Surgery III)
This study is looking at whether a special drip fluid, called L-glutamic acid, can help prevent kidney problems after heart bypass surgery. It focuses on adults having this surgery who don't have diabetes and are at risk of kidney injury.
For: Acute kidney injury and heart failure after coronary artery bypass surgery in patients without diabetesSweden - Ongoing, recruitingPhase II and Phase III (Integrated)
Intravenous lidocaine and post operative recovery after liver surgery – a randomized double blinded study
This study is looking at whether a pain medicine called lidocaine, given through a drip, can help reduce the amount of strong pain relief needed after liver surgery for tumours. Researchers want to see if it makes recovery smoother.
For: Patients with liver tumours that have liver surgery performedSweden - Ongoing, recruitingPhase II and Phase III (Integrated)
A multiple ascending dose (MAD) safety, tolerability and efficacy study of VRDN-001, a humanized monoclonal antibody directed against the IGF-1 receptor, in normal healthy volunteers (NHVs) and subjects with thyroid eye disease (TED)
This study is testing a new medicine, VRDN-001, for Thyroid Eye Disease (TED). It looks at how safe the medicine is, how well people tolerate it, and if it helps reduce eye bulging (proptosis) and other symptoms caused by TED. The study includes healthy volunteers and people with TED.
For: Thyroid eye disease (TED)Spain · Germany · France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
E-merge - Evaluation of MEpolizumab-based regimen Compared to Conventional Therapeutic Strategy For Remission Induction In Patients With Eosinophilic Granulomatosis With Polyangiitis. Prospective, randomized, controlled, double-blind study
This study is testing a new way to treat EGPA, a rare condition causing inflammation. It compares a new drug called mepolizumab to standard treatments to see if it can help patients reduce their steroid dose and avoid flare-ups.
For: Eosinophilic granulomatosis with polyangiitis (EGPA) · formerly called Churg-Strauss syndromeFrance - AuthorisedTherapeutic use (Phase IV)
EFFECT OF DEXAMETASONE ON LOWER LIMB EDEMA IN PATIENTS UNDERTAKEN FOR TOTAL HIP ARTHROPLASTY
This study is looking at whether a medicine called dexamethasone can help reduce swelling in the leg after a hip replacement operation. Researchers will compare it to a dummy treatment to see if it makes a difference.
For: POST -OPERATIVE LOWER LIMB EDEMASpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis
This study is looking into a new treatment called birtamimab for people with a serious heart condition called AL amyloidosis. Researchers want to see if birtamimab, given with standard care, can help people live longer compared to standard care alone.
For: Light Chain (AL) AmyloidosisBelgium · Denmark · Austria - AuthorisedTherapeutic confirmatory (Phase III)
Efficacy of certolizumab in women with unexplained recurrent implantation failure: a double-blind randomized controlled trial (CERTIFY)
This study looks into whether a medicine called Cimzia can help women who have had several failed attempts to get pregnant through IVF or similar treatments. It aims to see if it increases the chance of a successful pregnancy and birth.
For: Adult women with recurrent implantation failures (RIF)France - Ongoing, recruitingPhase II and Phase III (Integrated)
A Randomized, Double-Blind, Placebo-Controlled Study of Nab-Paclitaxel and Gemcitabine With Or Without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma
This study is testing a new drug, SBP-101, alongside standard treatments (Nab-paclitaxel and Gemcitabine) for advanced pancreatic cancer that hasn't been treated before. Researchers want to see if adding SBP-101 helps people live longer.
For: Metastatic Pancreatic Ductal AdenocarcinomaItaly · Belgium · Germany - AuthorisedTherapeutic confirmatory (Phase III)
The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis (other than for generalized peritonitis): a prospective, randomized, open-label, non-inferiority Phase III study.
This study is looking at whether giving antibiotics after surgery for a complicated appendix reduces new infections. It compares common antibiotics to see which works best for patients aged 18 and over, after keyhole surgery.
For: complicated acute appendicitisFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
CONDYVAC. Efficacy study of the quadrivalent Human Papilloma Virus (HPV) vaccine to prevent recurrence of External Genital Warts (EGW) in patients who were cured in the first place
This study looks at whether the HPV vaccine, Gardasil, can stop genital warts from coming back in people who have been successfully treated for them. It aims to see if the vaccine helps people stay wart-free after treatment.
For: External Genital Warts (EGW)France - AuthorisedTherapeutic confirmatory (Phase III)
Efficacy and safety of early intramuscular botulinum toxin injections in the prevention of shoulder deformity in infants with obstetric brachial plexus palsy: a randomized double-blind multicenter controlled trial.
This study looks at whether early injections of a medicine called botulinum toxin (Botox) can help prevent shoulder problems in babies with a condition called obstetric brachial plexus palsy. We want to see if it stops the shoulder joint from developing abnormally.
For: Obstetrical Brachial Plexus PalsyFrance - AuthorisedTherapeutic use (Phase IV)
Hip Infiltration in Hip Arthroplasty (HiHa) study – a randomized controlled trial
This study looks at different ways to manage pain after hip replacement surgery. Researchers want to see if a special injection into the hip joint can help reduce the need for extra pain relief in the first few hours after the operation.
For: Total Hip Arthroplasty / THANetherlands - AuthorisedTherapeutic confirmatory (Phase III)
Prolonged corticosteroid therapy in scheduled cardiac surgery in intermediate/high-risk patients: a prospective multicenter randomized controlled double-blind placebo-controlled study
This study is looking at whether giving certain steroid medicines before and after heart surgery in people with higher risks helps prevent problems like kidney failure or lung issues. It aims to see if these medicines are safe and effective.
For: high /medium risk cardiac surgery · acute renal failureFrance - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Pharmacodynamics of IMP 08P2002F0 (Fixed dose combination of 0.34% tropicamide and 2.5% phenylephrine hydrochloride, eye drop, Solution) a new ophthalmic mydriatic solution in healthy volunteers.
This study is testing new eye drops designed to make your pupils bigger. We want to see how quickly they work and how long they last. It's for people needing their pupils enlarged for eye exams or surgery.
For: to obtain pre-operative mydriasis or for diagnostic purposesGreece - AuthorisedPhase III and phase IV (Integrated)
LIDOCRIT : Effect of continuous intravenous LIDOCaine on discomfort in postoperative CRITical care inpatients
This study looks at whether a pain relief drug called lidocaine, given continuously into a vein, can help reduce discomfort for patients in critical care after an operation. It aims to see if it makes their recovery more comfortable.
For: Postoperative critical careFrance - AuthorisedTherapeutic confirmatory (Phase III)
A phase III, randomized, double-blind study assessing the efficacy and safety of intravenous lidocaine versus placebo in patients receiving intrathecal morphine analgesia in major digestive or abdominal surgery by laparotomy
This study looks at whether a medicine called lidocaine, given through a drip, can reduce the amount of strong pain relief (morphine) needed after major tummy surgery. We're also checking how safe and effective it is.
For: Major patients receiving morphine spinal anaesthesia for major gastrointestinal or abdominal surgery by scheduled laparotomy.France - AuthorisedTherapeutic confirmatory (Phase III)
TociCCAre - Randomized, double-blind, multicenter trial of tocilizumab versus placebo in chronic polyarticular inflammatory of calcium pyrophosphate deposition disease refractory to standard treatments
This study is testing a new treatment called tocilizumab for a type of arthritis called chondrocalcinosis, specifically when other treatments haven't worked well. It aims to see if this medicine can reduce pain.
For: ChondrocalcinosisFrance - AuthorisedTherapeutic confirmatory (Phase III)
Use of Isoprenaline with Epinephrine During Out-of-Hospital Cardiac Arrest with Non-Shockable Rhytm (EPISO)
This study looks at using isoprenaline with epinephrine for adults experiencing a cardiac arrest outside of a hospital, when their heart rhythm can't be corrected with an electric shock. It aims to see if this combination of medicines helps get the heart beating again and improves survival.
For: Cardiac arrestDenmark - AuthorisedTherapeutic confirmatory (Phase III)
ANAKINRA IN THE TREATMENT OF PEDIATRIC ACUTE MYOCARDITIS. ANAPEM
This study is looking at a new treatment called Kineret for children with a serious heart condition called myocarditis. It wants to see if Kineret helps their heart recover faster than a dummy treatment, by checking how well the heart pumps blood after 3 days.
For: PEDIATRIC ACUTE MYOCARDITISFrance - AuthorisedTherapeutic exploratory (Phase II)
Effect of perioperative intravenous infusion of lidocaine on the postoperative course and the immune response in patients undergoing surgery for colon cancer - the PILDI study
This study is looking at whether giving a common pain medication called lidocaine through a drip during colon cancer surgery can help reduce strong painkiller use afterwards. Researchers want to see if lidocaine can help patients recover better and need less opioid medication.
For: Colon cancerSlovenia - AuthorisedTherapeutic confirmatory (Phase III)
Lidocaine for opioid sparing in vaso-occlusive crisis of Sickle Cell Disease
This study looks at whether a medicine called lidocaine can help reduce the amount of strong pain relief needed for sickle cell pain crises in adults. It compares lidocaine plus usual care to usual care alone.
For: Sickle cell diseaseFrance - AuthorisedTherapeutic use (Phase IV)
Erector Spinae Plane Block for acute low back pain: a prospective double-blind randomized multicenter study. ESP-BACK
Researchers are looking into whether a new injection called an Erector Spinae Plane Block can help people with sudden, severe lower back pain feel better quickly. They want to see if it reduces pain and helps people move easier soon after the injection, compared to usual treatments.
For: Acute low back painFrance - AuthorisedTherapeutic use (Phase IV)
The effect of early Landiolol in patients with ST-elevation acute coronary syndrome undergoing primary percutaneous coronary intervention – A prospective, randomized, double- blinded, placebo controlled, phase IV pilot trial (STEMILAND-1)
This study is looking at whether a medicine called Landiolol can help people who have had a severe type of heart attack. Researchers want to see if giving this medicine early helps reduce further heart problems after emergency treatment.
For: ST-elevation acute coronary syndromeAustria - AuthorisedTherapeutic confirmatory (Phase III)
Postoperative recovery with the addition of long-acting NK1- and 5-HT3 receptor antagonists as prophylaxis for post-operative nausea and vomiting. A prospective, double-blind, randomized trial in laparoscopic surgery.
This study is looking at new ways to prevent sickness and vomiting after stomach surgery. It tests different medicines to see which ones help patients recover better and feel less sick after their operation. The goal is to make recovery an easier experience for people.
For: Post-operative nausea and vomiting (PONV)Sweden - AuthorisedTherapeutic use (Phase IV)
ILHEP : Effect of perioperative Intravenous Lidocaine on postoperative opioid related-side effects after open HEPatectomy: a multicentre prospective randomized controlled study
This study looks at whether a painkiller called lidocaine, given during and after liver surgery, can reduce side effects like sickness or breathing problems caused by other strong painkillers. It compares lidocaine to a salt solution to see if it helps patients recover better.
For: Postanesthetic complications in patients undergoing open hepatectomyFrance