solution clinical trials

A 12-week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma

This study is testing a new version of an asthma inhaler (CHF5993) to see if it's safe for people aged 18 and over with moderate to severe asthma. It compares the new version against an existing one over 12 weeks to ensure it works just as well and has similar side effects.

C5721002 _ A Randomized, Open-Label, Phase 3 Trial of Tisotumab Vedotin vs Investigator’s Choice Chemotherapy in Second- or Third-Line Recurrent or Metastatic Cervical Cancer

This study is testing a new drug (Tisotumab Vedotin) for cervical cancer that has come back or spread, and hasn't responded to previous treatments. It compares whether the new drug works better than standard chemotherapy to help people live longer.

RANDOMIZED, OPEN LABEL, PARALLEL-GROUP, TWO-ARM, MULTICENTER STUDY WITH CLINICAL ENDPOINT COMPARING PRESERVATIVE FREE BIMATOPROST OPHTHALMIC SOLUTION 0.1 MG/ML AND LUMIGAN® (BIMATOPROST OPHTHALMIC SOLUTION) 0.1 MG/ML IN PATIENTS WITH CHRONIC OPEN-ANGLE GLAUCOMA OR OCULAR HYPERTENSION IN ONE OR BOTH EYES.

This study compares two eye drops, one old and one new, for treating high eye pressure or glaucoma. We want to see if the new ‘preservative-free’ drops work as well and are as comfortable as the current ones. This could offer a gentler option for patients.

A prospective, randomized, double-blind placebo-controlled multicentre trial with mannan-conjugated birch pollen allergoids administered subcutaneously to adolescents and adults with birch pollen-induced allergic rhinitis or rhinoconjunctivitis.

This study is looking into a new treatment for birch pollen allergy. It compares a new vaccine-like medicine given by injection to a dummy treatment. The aim is to see if the new medicine can help reduce symptoms like sneezing and itchy eyes during pollen season.

TRAMORNOT: Tramadol versus morphine in postoperative analgesia after laparoscopic abdominal surgery: a randomized controlled trial

This study compares two pain medicines, tramadol and morphine, for pain after keyhole abdominal surgery. Researchers want to see which helps patients recover better and has fewer side effects. They are checking how well people feel 24 hours after their operation.

Phase 3, Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Recombinant Human Nerve Growth Factor Eye Drop Solution in Participants With Persistent Corneal Epithelial Defect (PCED)

This study looks at a new eye drop solution for people with persistent corneal epithelial defect (PCED), a long-lasting eye wound. It aims to see if the new drops can help the eye heal completely and safely within a few weeks.

A pragmatic, phase IV, randomized, open-label, multinational, multicentre, 2-arm parallel group, prospective study comparing efficacy and safety of Single Inhaler ICS/LABA/LAMA (beclometasone/formoterol fumarate/glycopyrronium bromide [87/5/9 pMDI {BD/FF/GB - 100/6/12.5 µg}]) vs Single Inhaler ICS/LABA (beclometasone dipropionate plus formoterol fumarate [200/6 pMDI {BD/FF - 200/6 µg}]) in asthma subjects.

This study compares two inhalers, Trimbow and Fostair, for adults with asthma. It looks at how well they control asthma symptoms and prevent flare-ups over a year, as well as their safety.

Symptoms control and adhErenCe assessment during treatment with mepolizUmab new pREfilled devices. SECURE

A randomized, double-blind, single-center, 2-period cross-over Phase I study to assess the tolerability, safety and pharmacokinetics of antidepressant doses of oral ketamine hydrochloride prolonged release tablets (KET01) compared to intranasal esketamine in healthy male subjects