solution injectable clinical trials

Effect of intravenous Lidocaine bolus on the median effective concentration (EC50) of Propofol during target controlled infusion (TCI : Schnider model) for gastroscopy in adult patients : a prospective, randomized, double-blinded study

This study looks at how a common painkiller called lidocaine, given through a drip, might help reduce the amount of a sleep-inducing medicine (propofol) needed for a gastroscopy. It aims to make the procedure smoother and more comfortable for adult patients.

Phase I/II randomized trial of LB-100 plus doxorubicin vs. doxorubicin alone in first line of advanced soft tissue sarcomas

This study is looking for adult patients with a certain type of advanced soft tissue sarcoma. It compares a new drug, LB-100, combined with standard doxorubicin treatment, against doxorubicin alone, to see how well it works and if it's safe.

Glenzocimab in Anterior stroke with Large Ischemic Core eligible for Endovascular therapy

This study looks at a new drug, Glenzocimab, for people who have had a severe stroke. It aims to see if the drug helps people recover better three months after their stroke, especially when combined with standard clot removal procedures.

Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis (JAKUVEITE)

This study is looking at a new tablet treatment called baricitinib (Olumiant) for a type of eye inflammation called uveitis. Researchers want to see if it can help improve symptoms and reduce the need for other medications over six months.

Efficacy of Intrathecal Morphine for Postoperative Analgesia with or without Suprainguinal Fascia Iliaca Block After Total Hip Arthroplasty: A Double-Blind Randomized Clinical Trial

This study looks at how well different pain relief methods work after hip replacement surgery, focusing on a strong painkiller given near the spine, sometimes with another pain relief injection. It aims to find the best way to manage pain and help people recover quickly.

Influencing Progression of Airway Disease in Primary Antibody Deficiency

This study looks at people with primary antibody deficiency to see if a higher dose of immunoglobulin (Ig) replacement therapy can slow down lung problems. We'll compare lung changes over two years using scans and other health measures. This could help improve treatment for these conditions.

(REGON) Repeated corticosteroid injections around the Greater Occipital Nerve (GON) as prophylactic treatment in chronic cluster headache

This study looks at whether regular injections around a nerve in the back of the head can help prevent severe "cluster headaches." It compares a pain-relieving medicine with a dummy injection to see how long people stay free from their usual headache patterns.

MIVAR - Milrinone Infusion for VAsospam treatment in subarachnoid hemoRrhage

This study looks at a new treatment called Milrinone for people who have had a bleeding stroke in their brain, called a subarachnoid haemorrhage. It aims to see if Milrinone can help improve recovery three months after the stroke by preventing a problem called vasospasm.

Interest of Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis: a randomized controlled study. "BIGG" : Bartonellosis and intra-nodal injection of gentamicin

This study looks at a new way to treat cat scratch disease, an infection that can cause swollen glands. Doctors are testing if injecting an antibiotic directly into the swollen gland works better than other treatments to reduce swelling and pain.

Does high-dose vitamin B3 supplementation prevent major adverse kidney events during septic shock? A multicenter randomized controlled study.

This study looks at whether a high dose of vitamin B3 can help prevent serious kidney problems in very sick patients called "septic shock." It compares vitamin B3 to a dummy treatment to see if it helps reduce deaths or the need for kidney dialysis.

Randomized Clinical Trial of Inhaled Sedation with Sevoflurane in Critically Ill Patients at Risk of Developing the Acute Respiratory Distress Syndrome

This study is looking at different ways to sedate (keep calm) very sick patients in intensive care (ICU) who are at risk of a serious lung condition called ARDS. It compares inhaled sedation with standard methods to see if it helps lung function and overall recovery.

Ketamine infusion for symptomatological improvement of severe borderline personality disorder: a pilot study

This study is looking at whether a specific dose of ketamine, delivered as an infusion, can help improve severe symptoms in adults with Borderline Personality Disorder (BPD). It's a small, early-stage study to see if this treatment might be helpful.

Patient reported efficacy of intranasal lysine-aspirin in controlling NSAID-exacerbated respiratory disease.

This study looks at a new way to treat breathing problems caused by pain medicines like ibuprofen or naproxen. It uses a nasal spray with a common painkiller, aspirin, to see if it can improve symptoms like stuffy nose and asthma, and reduce side effects.

Rituximab therapy in anti-MAG patients with characteristics of good responders: THERAMAG study

This study looks at whether a medicine called rituximab, given with salt water, can help people in the UK with a nerve condition called anti-MAG neuropathy. Researchers want to see if it improves their symptoms over 12 months.

A randomized non-comparative phase II study of Maintenance therapy with OSE2101 plus FOLFIRI, or FOLFIRI after induction therapy with FOLFIRINOX in patients with locally advanced or metastatic Pancreatic ductal adenocarcinoma.

This study looks at different treatment approaches for pancreatic cancer that has spread or is advanced. It combines standard chemotherapy with a new drug called OSE2101 or uses chemotherapy alone, after an initial treatment. The main goal is to see how long people live.

BALLAD Belgium - A trial to evaluate the potential benefit of adjuvant chemotherapy for small bowel adenocarcinoma. The Belgian component of the Global Ballad pooled data analysis.

This study, called BALLAD, is looking into whether extra chemotherapy after surgery can help people with a type of bowel cancer called small bowel adenocarcinoma. It's a big study involving different countries, and explores how long people live without the cancer coming back, and other important health measures.

KETALGIA : Evaluation of the effectiveness of a ketamine infusion combined with magnesium sulfate in the treatment of chronic refractory cluster headache

This study is looking into whether a special drip (infusion) containing ketamine and magnesium could help people in the UK who suffer from very severe, ongoing cluster headaches. Researchers want to see if this treatment can reduce how often these painful headaches occur.

EFFICACY OF USUAL MANAGEMENT BY LOCAL ANESTHETIC INFILTRATION IN THE TREATMENT OF CHRONIC IDIOPATHIC ANO-PERINEAL PAIN: A RANDOMIZED DOUBLE-BLIND -CONTROLLED TRIAL

This study is testing if injections of a local anaesthetic drug provide better pain relief for ongoing lower back and bottom pain compared to a salt water injection. We want to see if the anaesthetic can reduce pain significantly after one month.

Benefits on Post-operative Pain of Intravenous, Intraoperative, Tranexamic Acid Injection During Arthroscopic Shoulder Surgery.

This study is looking at whether a medicine called tranexamic acid can help reduce pain after shoulder surgery. Researchers will check if patients who receive it need less strong pain medication (morphine) in the first 24 hours after their operation.

Randomized controlled double-blind study ESKAPE : ESKetamine low-dose versus ketamine low-dose for Severe Acute Pain in Emergency Departments, comparison of PsychodyslEptic effects

This study is comparing two similar pain relief medicines, ketamine and esketamine, for severe sudden pain in accident and emergency. Researchers want to see if one causes fewer unusual side effects, like feeling strange or confused, while still being good at managing pain.

Echo-guided scalp blocks and incidence of postoperative pain in scheduled supratentorial intracranial surgery - ULTRASCALP

This study, called ULTRASCALP, is looking at how well a special type of pain relief, given before brain surgery, helps manage pain afterwards. It aims to see if blocking nerves with ultrasound guidance can reduce the need for strong painkillers and severe pain.

A phase III, randomized, double-blind study assessing the efficacy and safety of intravenous lidocaine versus placebo in patients receiving intrathecal morphine analgesia in major digestive or abdominal surgery by laparotomy

This study looks at whether a medicine called lidocaine, given through a drip, can reduce the amount of strong pain relief (morphine) needed after major tummy surgery. We're also checking how safe and effective it is.

Efficacy and safety of allogenic cultured Adipose-derived mesenchymal stromal cell injections on MoUth fibrosis and handicap in patients with Systemic sclEroderma

This study is looking at a new treatment for mouth problems caused by Systemic Sclerosis. It uses special cells injected to see if they can reduce mouth stiffness and improve daily activities. Researchers will check if patients feel better and if the treatment is safe.

Pharmacokinetic study of the use of Nefopam 30 mg tablet in patients suffering from acute pain in rheumatology - NEFOPAIN kinetics

This study looks at how a pain medication called Nefopam works in people with sudden joint and muscle pain in hospitals. Researchers are checking how the body handles the medicine, seeing if the tablet and injection versions are similar, and aiming to find the best dose.

Impact of low dose epinephrine in the management of out-of-hospital cardiac arrest on neurological outcome: A multicenter randomized and double-blind trial (Low-EPI Study)

This study, called Low-EPI, is looking at whether a lower dose of adrenaline (epinephrine) given to people who have a sudden cardiac arrest outside of a hospital can help them recover better, especially with their brain function, compared to the usual dose. We want to see if it improves their health after 28 days.

Preoperative use of Romiplostim in thrombocytopenic patients undergoing cardiac surgery. A Phase 3, multicenter randomized double-blinded controlled against placebo study

This study looks at a new medicine called Nplate for people with low platelet counts undergoing heart surgery. It aims to see if Nplate can help prevent bleeding and reduce the need for blood transfusions during and after operations.

Comparison of morphine and alfentanil in the emergency treatment of severe acute pain in the pre-hospital setting

This study compares two pain medications, morphine and alfentanil, given by paramedics for severe pain before reaching hospital. Researchers want to see which one works better at bringing pain down quickly and safely in an emergency.

International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 - A Randomized Phase III Study Conducted by the Resistant Disease Committee of the International BFM Study Group - IntReALL BCP 2020

This study looks at new ways to treat children with a type of blood cancer called B-cell acute lymphoblastic leukaemia, which has come back after earlier treatment. It compares different drug combinations to find the most effective and safest options for them.

Intermediate versus standard dose enoxaparin to prevent venous thromboembolism in severe trauma patients: a multicenter double blind randomised controlled trial (HEPTRAUMA)

This study looks at different doses of a blood-thinning medicine (Lovenox) in people with severe injuries. The aim is to find the best dose to prevent dangerous blood clots like DVT (deep vein thrombosis) and PE (pulmonary embolism) without causing too much bleeding.

Efficacy of intravenous dexamethasone in prolonging the duration of spinal anesthesia with chloroprocaine in knee arthroscopy.

This study looks at using a common medicine called dexamethasone with a spinal anaesthetic during knee surgery. The goal is to see if it makes the pain relief last longer, so patients stay comfortable for more of their recovery after a knee arthroscopy.

A Prospective, Multi-National, Randomized, Double-Blind, Crossover Study to Evaluate the Efficacy and Safety of Gadopiclenol-enhanced MRA Compared to Gadoterate Meglumine-enhanced MRA in the Assessment of Steno-occlusive Disease in Adult Patients with Suspected Vascular Disease

This study is comparing two dye injections used with MRI scans to help doctors see blood vessels better. It's for adults who might have problems with their blood vessels, like blockages. The aim is to see which dye works best and is safest for finding these problems.

KARMA - INtenSive care TreAtmeNT with adjuvant KetAmine and Recovery after Mechanical ventilAtion: a multicenter doubleblind randomized controlled trial

This study looks into using a drug called ketamine for very sick patients on breathing machines in intensive care. The aim is to see if it helps them recover better, spend more days at home, and live longer after leaving the hospital.

Dose Study of Tranexamic Acid in Total Hip Replacement to Reduce Postoperative Hemoglobin Loss. A Phase 2 Randomized Double-blind Monocentric Study. The PRADO study