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Methotrexate treatment in hand osteoarthritis refractory to usual treatments: A randomised, double-blind, placebo-controlled trial, ADEM2 study

This study looks at whether a medicine called methotrexate can help people with severe hand osteoarthritis that hasn't improved with other treatments. It specifically focuses on an aggressive type of hand osteoarthritis where joints get damaged. Researchers want to see if methotrexate can slow down this damage.