Tabletten clinical trials

Phase 1/2 Dose Finding, Safety and Efficacy Study of Ibrutinib in Pediatric Subjects with Chronic Graft Versus Host Disease (cGVHD)

This study is looking at a medicine called ibrutinib for children and young people with chronic Graft Versus Host Disease (cGVHD). It aims to find the right dose and check how safe and effective it is for those aged 1 to 22 years.

ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Mycobacterial (NTM) Lung Infection Caused by Mycobacterium avium Complex (MAC)

This study is testing a new inhaled medicine for people with a lung infection called MAC. It wants to see if the new medicine, given with other standard treatments, makes breathing symptoms better and helps clear the infection compared to standard treatments alone.

A stratification trial to determine key immunological factors predicting Tofacitinib efficacy in Psoriatic Arthritis (PsA); TOFA-PREDICT

This study, called TOFA-PREDICT, looks at how a medicine called Tofacitinib works for people with Psoriatic Arthritis. Researchers want to understand why it helps some people more than others by looking at their body's chemistry before and during treatment.

HepBTer: From fungus to virus, a phase 2a clinical trial investigating the safety and efficacy of terbinafine in chronic hepatitis B patients

This study, called HepBTer, is testing a medicine called terbinafine to see if it can help people with long-lasting hepatitis B. Researchers are looking at how safe the medicine is and if it reduces the amount of virus in the body over 10 weeks. This is an early-stage study.

Clemastine fumarate as remyelinating treatment in internuclear ophthalmoparesis and multiple sclerosis (RESTORE)

This study looks at a medicine called clemastine to see if it can help people with multiple sclerosis (MS) or a related eye problem called internuclear ophthalmoparesis. It's a late-stage trial, aiming to confirm if the treatment works by improving eye movement over 6 months and beyond.

Anticoagulant medicines for Balloon Pulmonary Angioplasty

This study looks at how safe different blood-thinning medicines are during a procedure called Balloon Pulmonary Angioplasty (BPA). It focuses on patients with specific lung conditions to see if these medicines cause issues like bleeding or lung problems.

Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.

This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.

TRAMORNOT: Tramadol versus morphine in postoperative analgesia after laparoscopic abdominal surgery: a randomized controlled trial

This study compares two pain medicines, tramadol and morphine, for pain after keyhole abdominal surgery. Researchers want to see which helps patients recover better and has fewer side effects. They are checking how well people feel 24 hours after their operation.

The efficacy of pipamperone and aripiprazole on behaviors that challenge in people with intellectual disabilities: A series of N-of-1 cross-over trials

This study looks at how well two medicines, pipamperone and aripiprazole, help people with learning disabilities manage challenging behaviours. It compares how people are doing with and without these medicines to see if they make a positive difference.

SHIELD – Swift Hydrocortisone Intervention after trauma exposure

This study, called SHIELD, is looking at whether a low dose of a medicine called hydrocortisone can help people who have recently experienced a traumatic event. It aims to see if starting this medicine quickly can lower the chances of developing PTSD symptoms or make them less severe.

Methotrexate in paediatric and adolescent Crohn’s disease: an observational study

This study looks at how well a medicine called methotrexate works for young people with Crohn's disease over a year. It checks how much of the medicine stays in the body and if patients need to stop using it due to side effects or if it's not helping enough.

A randomized, placebo-controlled trial to assess the efficacy, tolerability, and pharmacokinetics of clemastine in children and adults with Pitt-Hopkins syndrome

This study is testing a medicine called clemastine for people with Pitt-Hopkins syndrome. It's in an early stage (Phase II) to see if it helps with symptoms and is safe to use. Researchers want to know how patients feel and how their bodies handle the medicine.

MERCURE study: MEthotrexate in ReCurrent dVIN

This study looks at whether a medicine called methotrexate can help women with a skin condition called dVIN, linked to lichen sclerosus, stop it from coming back. It compares if dVIN returns less often when women take methotrexate versus when they don't.

HO183 CAR T: A phase III randomized trial comparing academically produced BCMA-directed CAR T-cells (ARI0002h) with standard of care regimen in patients with relapsed/refractory multiple myeloma

This study compares a new cell therapy (CAR T-cells) with standard treatments for multiple myeloma that has come back or not responded to previous treatments. It aims to see if the new therapy helps people live longer without their cancer getting worse.

The effect of oral folinic acid rescue therapy on pemetrexed induced neutropenia and other toxicity: A randomized open-label trial.

A Randomized, Double-blind, Double Placebo-controlled, 4-Period Crossover Study to Evaluate the Central Nervous System Pharmacodynamic Activity of Brexanolone Using Transcranial Magnetic Stimulation in Healthy Male Participants