Tacrolimus clinical trials

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

This study is testing a new medicine, povetacicept, for people with a kidney condition called primary membranous nephropathy (pMN). It aims to see how well it works, if it's safe, and if people can tolerate it compared to another treatment, tacrolimus.

A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications

This study compares two ways to help young people (12-17) after a kidney transplant. It looks at changing medicine from one type (calcineurin inhibitor) to another (belatacept-based) and how well patients stick to their treatment. It aims to see which approach works best.

A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation

This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.

A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy

This study is testing a new medicine called zanubrutinib for people with a kidney condition called primary membranous nephropathy. It compares zanubrutinib with a standard medicine, tacrolimus, to see how well it reduces protein in the urine and helps people get better.

Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipients

This study looks at the long-term safety and effectiveness of a new drug, tegoprubart (also called AT-1501), compared to a standard drug, tacrolimus. It's for people who have had a kidney transplant to help prevent their body from rejecting the new kidney.

Safety and efficacy of steering of immunosuppression based on BKPyV-specific T cells in case of BK Polyomavirus (BKPyV) DNAe- mia after kidney transplantation

This study looks at how well a new approach to adjusting medicines helps control a common virus called BK Polyomavirus (BKPyV) in people who have had a kidney transplant. The goal is to find the best way to keep the new kidney healthy.

A randomized controlled, two-arm (1:1 ratio) Phase IIa trial to assess the efficacy and safety of obinutuzumab in treating adults with de novo minimal change disease

This study is testing a new medicine called obinutuzumab for a kidney condition called minimal change disease. We want to see if it works as well as, or better than, current treatments, and if it's safe for adults.

A non-inferiority, randomised and controlled trial to compare the safety, tolerability and preliminary efficacy between standard and Torque Teno virus-guided immunosuppression in stable adult kidney transplant recipients with low immunological risk in the first year after transplantation

A Phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, multinational, multicenter study to evaluate the efficacy and safety of amlitelimab monotherapy by subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis.

A Phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, multinational, multicenter study to evaluate the efficacy and safety of amlitelimab monotherapy by subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis - EFC17559 / COAST1

Phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, multinational, multicenter study to evaluate the efficacy and safety of amlitelimab by subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis on background topical corticosteroids - EFC17561 - SHORE

Evaluation of the effect of tacrolimus on carbohydrate metabolism in pre-renal transplantation dialysis patients

Graft vs Host Disease Prophylaxis in unrelated donor transplantation: a randomized clinical trial comparing PTCY vs ATG