- RecruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
For: CancerUnited States · Argentina · Australia - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
For: RhabdomyosarcomaAustralia · Austria · Belgium - Active not recruitingPHASE2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
This study looks at adding a cannabis-based medicine (Nabiximols) to standard treatment (Temozolomide) for a type of brain tumour called glioblastoma that has come back. It aims to see if this combination works better than standard treatment alone.
For: Glioblastoma · Brain Tumor · CannabisUnited Kingdom - RecruitingPHASE3
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
This study is looking at a new way to treat glioblastoma brain tumours that have come back. It combines a special ultrasound device called SonoCloud-9 with an anti-cancer drug, carboplatin, to see if it works better than standard treatments.
For: Glioblastoma · Recurrent Glioblastoma · GBMUnited States · Austria · Belgium - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - RecruitingPHASE2, PHASE3
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
This study is testing different treatments for a type of brain cancer called glioblastoma. It's for people who have been recently diagnosed or whose cancer has come back. The aim is to find better ways to treat this cancer.
For: GlioblastomaUnited States · Australia · Canada - Active not recruitingPHASE2
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
This study looks at a new drug, palbociclib, combined with standard chemotherapy for children, teenagers, and young adults with certain cancers that have come back or are hard to treat. It aims to find a safe dose and see how well it works.
For: Ewing Sarcoma · Solid Tumors · Rhabdoid TumorUnited States · Brazil · Canada - RecruitingPHASE3
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
This study compares a new treatment called IMA203 with standard care for advanced skin melanoma that has already been treated. Its main goal is to see if IMA203 is more effective and safe for patients who have limited treatment options.
For: Melanoma, Cutaneous MalignantUnited States · Canada · France - RecruitingPHASE2
A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma
This study is looking at a new type of treatment called liso-cel for adults with a brain lymphoma that can't have a stem cell transplant. It aims to see how safe and effective this new treatment is as the first treatment they receive.
For: LymphomaUnited States · France · Germany - RecruitingPHASE3
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
This study looks at a new combination treatment for a type of brain cancer called glioblastoma. It combines a device called Optune, a chemotherapy drug called temozolomide, and a new drug called pembrolizumab, comparing it to Optune, temozolomide, and a dummy drug.
For: GlioblastomaUnited States · Canada · Czechia - RecruitingPHASE1, PHASE2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This study is for children and young people with cancer that hasn't responded to usual treatments. It tests new medicines that target specific changes in cancer cells, aiming to find the right dose and see if they help. The goal is to find better ways to treat childhood cancer.
For: Pediatric CancerDenmark · France · Italy - Active not recruitingPHASE1
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.
This study looks at a new treatment called [177Lu]Lu-DOTA-TATE for glioblastoma, a type of brain tumour. It's testing different doses and how well it works, both on its own and with usual treatments, in people recently diagnosed or whose cancer has come back.
For: GlioblastomaUnited States · France · Portugal - RecruitingPHASE1, PHASE2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
This study looks at new drug combinations (Onivyde with talazoparib or temozolomide) for children and young adults with solid cancers that have come back or not responded to previous treatment, especially Ewing sarcoma. The aim is to find the safest, most effective dose.
For: Recurrent Solid Tumor · Recurrent Ewing Sarcoma · Recurrent HepatoblastomaUnited States · Canada - Active not recruitingPHASE2
Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)
This study looks at combining existing treatments for high-risk neuroblastoma to see if it works better. It's for children and young people who have already had intensive therapy, to help prevent the cancer from coming back.
For: Ganglioneuroblastoma, Nodular · NeuroblastomaUnited States · Australia · Canada - RecruitingPHASE3
The Sagittarius Trial
This study looks at new ways to treat colon cancer after surgery to stop it coming back. It uses advanced tests called 'liquid biopsies' to help doctors choose the best treatment for each person, aiming for better results and fewer side effects.
For: Colon Cancer Stage II · Colon Cancer Stage IIIGermany · Italy · Spain - Not yet recruitingPHASE2
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
This study is for people with advanced solid tumours that have a specific genetic change called an MTAP deletion. It's testing a new medicine, BMS-986504, alone and with other cancer treatments, to see how safe and effective they are.
For: Solid TumorsUnited States · Belgium · Canada - Active not recruitingPHASE1, PHASE2
AGuIX Nanoparticles With Radiotherapy Plus Concomitant Temozolomide in the Treatment of Newly Diagnosed Glioblastoma
This study looks at a new treatment for a type of brain cancer called glioblastoma. It combines standard treatments (radiotherapy and other medicine) with special ‘nanoparticles’ called AGuIX. The aim is to see if this new combination is safe and effective.
For: GlioblastomaFrance - Active not recruitingPHASE1
Dose Finding Study of [177Lu]Lu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma
This study is looking for better ways to treat glioblastoma, a type of brain tumour. It tests a new treatment, [177Lu]Lu-NeoB, both with standard care for newly diagnosed patients and by itself for those whose cancer has returned. The main goal is to find a safe and effective dose.
For: Newly Diagnosed and Recurrent GlioblastomaUnited States · France · Germany - Active not recruitingPHASE2
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma
This study looks at new ways to treat neuroblastoma that has come back or isn't responding to usual treatments. It tests if adding a drug called eflornithine to other medicines helps children with this type of cancer.
For: High Risk Neuroblastoma · Recurrent Neuroblastoma · Refractory NeuroblastomaUnited States · Australia · Canada - RecruitingPHASE1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This early-stage study is testing a new drug, INBRX-109, for people with advanced solid tumours, including certain types of Ewing sarcoma and bowel cancer. Researchers want to see if it's safe and how well it works, both alone and with standard treatments. This is for patients who haven't responded to previous therapies.
For: Ewing Sarcoma · Colorectal AdenocarcinomaUnited States · France · Italy - Active not recruitingPHASE3
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
This study is looking at a new combination of medicines, naporafenib and trametinib, for people with a specific type of advanced melanoma. It aims to see if this combination works better than standard treatments for patients whose melanoma has certain genetic changes and has progressed after other treatments.
For: Advanced or Metastatic NRAS-mutant MelanomaUnited States · Australia · Canada - Active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
For: Glioblastoma · Melanoma Stage IV · Breast CancerUnited States · United Kingdom - AuthorisedTherapeutic exploratory (Phase II)
Quality of life and neurocognitive functioning in diffuse low-grade glioma patients treated with Temozolomide: feasibility study - TEMOIN
This study is looking at how a treatment called Temozolomide affects quality of life and brain function in people with a type of brain tumour called 'diffuse low-grade glioma'. It's a small, early-stage study to see if a larger study would be practical.
For: Diffuse low-grade gliomasFrance - Active not recruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
For: Glioblastoma · GBM · Brain Neoplasms, Adult, MalignantUnited States · Australia · Canada - RecruitingPHASE2
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
This study is a research programme looking at new ways to treat cancer in children and young adults aged 1 to 39. It tests different medicines to find out how well they work and if they are safe.
For: Neoplasms · Child · AdolescentUnited States · Australia · Belgium - Active not recruitingPHASE3
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme
This study is looking at a new way to treat a type of brain tumour called glioblastoma. It compares standard treatment with adding a special type of radiation given during surgery. The aim is to see if this new approach can help people live longer without their cancer growing back.
For: GlioblastomaUnited States · Brazil · Canada - RecruitingPHASE1, PHASE2
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
This study is testing two new drugs, avutometinib and defactinib, alone and with temozolomide, for people with aggressive brain tumours like glioblastoma. It aims to see if they are safe and can shrink tumours, particularly in patients with specific genetic changes.
For: Glioblastoma Multiforme (GBM) · Glioblastoma Multiform (Grade IV Astrocytoma) · Diffuse Hemispheric Glioma, H3 G34-MutantUnited Kingdom