- Ongoing, recruitingTherapeutic exploratory (Phase II)
J1S-MC-JP04: A Randomized, Open-Label Phase 2 Study Evaluating Abemaciclib in Combination with Irinotecan and Temozolomide in Participants with Relapsed or Refractory Ewing’s Sarcoma
This study is looking at a new way to treat Ewing's sarcoma that has come back or hasn’t responded to previous treatments. It uses a tablet called Verzenios (abemaciclib) along with two chemotherapy drugs, irinotecan and temozolomide. Researchers want to see how well this combination stops the cancer from growing.
For: Ewings SarcomaItaly · Spain · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
PEMBROLIZUMAB IN MMR-PROFICIENT METASTATIC COLORECTAL CANCER PHARMACOLOGICALLY PRIMED TO TRIGGER DYNAMIC HYPERMUTATION STATUS - THE ARETHUSA TRIAL
This study looks at a new way to treat advanced bowel cancer that has spread. It combines existing chemotherapy with an immunotherapy drug, pembrolizumab, hoping to make the immunotherapy more effective for people whose cancer hasn't responded to previous treatments.
For: Metastatic colorectal cancerItaly - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I/II multicenter study to assess efficacy and safety of ribociclib (LEE011) in combination with topotecan and temozolomide (TOTEM) in pediatric patients with relapsed or refractory neuroblastoma and other solid tumors
This study is looking at a new combination of medicines for children and young people with certain types of cancer that have come back or not responded to previous treatments. It aims to find the right dose and see how well the medicines work and if they are safe.
For: Relapsed or refractory neuroblastoma and other solid tumors (including medulloblastoma · high grade glioma · malignant rhabdoid tumorsSpain · Germany · France - RecruitingPHASE2
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
This study is a research programme looking at new ways to treat cancer in children and young adults aged 1 to 39. It tests different medicines to find out how well they work and if they are safe.
For: Neoplasms · Child · AdolescentUnited States · Australia · Belgium - RecruitingPHASE1, PHASE2
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
This study is testing two new drugs, avutometinib and defactinib, alone and with temozolomide, for people with aggressive brain tumours like glioblastoma. It aims to see if they are safe and can shrink tumours, particularly in patients with specific genetic changes.
For: Glioblastoma Multiforme (GBM) · Glioblastoma Multiform (Grade IV Astrocytoma) · Diffuse Hemispheric Glioma, H3 G34-MutantUnited Kingdom - Active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
For: Glioblastoma · Melanoma Stage IV · Breast CancerUnited States · United Kingdom - Active not recruitingPHASE3
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme
This study is looking at a new way to treat a type of brain tumour called glioblastoma. It compares standard treatment with adding a special type of radiation given during surgery. The aim is to see if this new approach can help people live longer without their cancer growing back.
For: GlioblastomaUnited States · Brazil · Canada - RecruitingPHASE1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This early-stage study is testing a new drug, INBRX-109, for people with advanced solid tumours, including certain types of Ewing sarcoma and bowel cancer. Researchers want to see if it's safe and how well it works, both alone and with standard treatments. This is for patients who haven't responded to previous therapies.
For: Ewing Sarcoma · Colorectal AdenocarcinomaUnited States · France · Italy - Active not recruitingPHASE2
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
This study looks at a new drug, palbociclib, combined with standard chemotherapy for children, teenagers, and young adults with certain cancers that have come back or are hard to treat. It aims to find a safe dose and see how well it works.
For: Ewing Sarcoma · Solid Tumors · Rhabdoid TumorUnited States · Brazil · Canada - RecruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
For: CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - AuthorisedTherapeutic exploratory (Phase II)
Multisite open-label randomized phase II clinical trial in newly diagnosed glioblastoma treated by concurrent TemoRadiation and adjuvant temozolomide +/- ultrasound-induced blood brain barrier opening - SonoFIRST
This study looks at a new way to treat a serious type of brain cancer called glioblastoma. We're testing if sound waves can help medicines work better when given with standard treatments like chemotherapy and radiotherapy.
For: Newly diagnosed Glioblastoma (IDH wild-type) patients at initial radiological diagnosis eligible for tumor resectionFrance · Belgium - RecruitingPHASE2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
This study looks at adding a cannabis-based medicine (Nabiximols) to standard treatment (Temozolomide) for a type of brain tumour called glioblastoma that has come back. It aims to see if this combination works better than standard treatment alone.
For: Glioblastoma · Brain Tumor · CannabisUnited Kingdom - RecruitingPHASE3
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
This study looks at a new combination treatment for a type of brain cancer called glioblastoma. It combines a device called Optune, a chemotherapy drug called temozolomide, and a new drug called pembrolizumab, comparing it to Optune, temozolomide, and a dummy drug.
For: GlioblastomaUnited States · Canada · Czechia - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
I3Y-MC-JPCS: A Phase 1b/2 Study of Abemaciclib in Combination with Irinotecan and Temozolomide (Part A) and Abemaciclib in Combination with Temozolomide (Part B) in Pediatric and Young Adult Patients with Relapsed/Refractory Solid Tumors and Abemaciclib in Combination with Dinutuximab, GM-CSF, Irinotecan, and Temozolomide in Pediatric and Young Adult Patients with Relapsed/Refractory Neuroblastoma (Part C).
This study is testing a new medicine, abemaciclib, combined with other treatments for children and young adults with solid cancers that have come back or not responded to previous treatment. Researchers want to find the safest and most effective dose.
For: Relapsed/Refractory Solid TumorsSpain - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A5481092: PHASE 1/2 STUDY TO EVALUATE PALBOCICLIB (IBRANCE®) IN COMBINATION WITH IRINOTECAN AND TEMOZOLOMIDE OR IN COMBINATION WITH TOPOTECAN AND CYCLOPHOSPHAMIDE IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS
This study looks at new drug combinations for children with specific types of cancer (Ewing sarcoma or neuroblastoma) that have come back or not responded to previous treatment. It tests how safe and effective these combinations are.
For: recurrent/refractory Ewing sarcoma · recurrent or refractory neuroblastomaSweden · France · Czechia - AuthorisedTherapeutic exploratory (Phase II)
Quality of life and neurocognitive functioning in diffuse low-grade glioma patients treated with Temozolomide: feasibility study - TEMOIN
This study is looking at how a treatment called Temozolomide affects quality of life and brain function in people with a type of brain tumour called 'diffuse low-grade glioma'. It's a small, early-stage study to see if a larger study would be practical.
For: Diffuse low-grade gliomasFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
BEACON: A randomised phase IIb trial of BEvACizumab added to Temozolomide ± IrinOtecan for children with refractory/relapsed Neuroblastoma
This study looks at new ways to treat children with neuroblastoma that has come back or not responded to previous treatments. It combines standard chemotherapy drugs with a new medicine called bevacizumab to see if this helps shrink the cancer or stop it from growing.
For: NeuroblastomaBelgium · Spain · Netherlands - RecruitingPHASE3
SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma
This study compares a new treatment called IMA203 with standard care for advanced skin melanoma that has already been treated. Its main goal is to see if IMA203 is more effective and safe for patients who have limited treatment options.
For: Melanoma, Cutaneous MalignantUnited States · Canada · France - Active not recruitingPHASE3
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
This study is looking at a new combination of medicines, naporafenib and trametinib, for people with a specific type of advanced melanoma. It aims to see if this combination works better than standard treatments for patients whose melanoma has certain genetic changes and has progressed after other treatments.
For: Advanced or Metastatic NRAS-mutant MelanomaUnited States · Australia · Canada - RecruitingPHASE1, PHASE2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This study is for children and young people with cancer that hasn't responded to usual treatments. It tests new medicines that target specific changes in cancer cells, aiming to find the right dose and see if they help. The goal is to find better ways to treat childhood cancer.
For: Pediatric CancerDenmark · France · Italy - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
For: RhabdomyosarcomaAustralia · Austria · Belgium - AuthorisedPhase I and Phase II (Integrated)- Other
BEACON 2: A Multi-Arm, Multi-Stage Platform Trial For Relapsed Neuroblastoma
This study, BEACON 2, is looking for better ways to treat neuroblastoma, a type of cancer, in young people and adults when it has come back or not responded to previous treatments. It tests new combinations of existing medicines.
For: High risk relapsed neuroblastoma (relapsed or progressed after being defined as High Risk at any time following diagnosis or progressed/relapsed as high-risk neuroblastoma) · which is histologically proven as per International Neuroblastoma Staging System (INSS) definition.France · Austria · Germany - AuthorisedTherapeutic exploratory (Phase II)
Ipilimumab and nivolumab plus temozolomide and capecitabine for patients with chemo-refractory pMMR, MGMT silenced metastatic colorectal cancer: The MAYA2 trial
This study is looking at a new combination of existing cancer drugs for people with bowel cancer that has spread and hasn't responded to earlier chemotherapy. It aims to see how well these new drug combinations control the cancer when given together.
For: Colorectal cancerDenmark - AuthorisedTherapeutic exploratory (Phase II)
MATVAC-1 : EVALUATION OF UCPVAX VACCINE +/- PEMBROLIZUMAB COMBINED WITH STANDARD TREATMENT AS ADJUVANT THERAPY IN PATIENTS WITH UNMETHYLATED MGMT GLIOBLASTOMA
This study is looking at new treatments for a type of brain cancer called glioblastoma. It's testing a vaccine called UCPVAX, sometimes with another drug called pembrolizumab, alongside standard care, to see if it helps people live longer after treatment.
For: GlioblastomaFrance - RecruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
For: Glioblastoma · GBM · Brain Neoplasms, Adult, MalignantUnited States · Australia · Canada