- Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus–Pancreatic Cancer)
This study is testing different combinations of new drug treatments for people with advanced pancreatic cancer. Doctors want to see how well these combinations shrink tumours and if they are safe to use.
For: Pancreatic ductal adenocarcinoma (PDAC)Spain - Active not recruitingPHASE3
A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)
This study is looking at new ways to treat advanced liver cancer that can't be removed by surgery. It combines existing medications with a new one to see if this mix works better and is safe. The aim is to find improved first-line treatments for this type of cancer.
For: Hepatocellular CarcinomaUnited States · Belgium · Brazil - Active not recruitingPHASE3
A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy
This study looks at new treatments for a type of oesophageal cancer that hasn't spread after initial therapy. It tests two new medicines, tiragolumab and atezolizumab, to see if they can help stop the cancer from coming back or getting worse.
For: Esophageal Squamous Cell CarcinomaUnited States · Argentina · Australia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A PHASE II, OPEN LABEL, RANDOMIZED, NON-COMPARATIVE COHORTS STUDY OF ADJUVANT ATEZOLIZUMAB OR ATEZOLIZUMAB PLUS TIRAGOLUMAB IN SOLID TUMORS WITH RESECTABLE DISEASE WITH INTERMEDIATE-HIGH RISK OF RECURRENCE AND HIGH TUMOR MUTATIONAL BURDEN (TMB-H) OR MICROSATELLITE INSTABILITY (MSI-H) (IMperator)
This study looks at new treatments (atezolizumab and tiragolumab) for people with certain solid cancers that have been removed by surgery. It aims to see if these treatments can help stop the cancer from coming back.
For: Solid tumorsSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Open-Label, Randomized Study of Atezolizumab and Tiragolumab Compared with Durvalumab in Patients with Locally Advanced, Unresectable Stage III Non-Small Cell Lung Cancer who have not Progressed after Concurrent Platinum-Based Chemoradiation (SKYSCRAPER-03)
This study looks at new treatments for a type of lung cancer that has not spread widely. It compares two drug combinations to see which is better at stopping the cancer from growing after initial treatment.
For: Non−small cell lung cancer (NSCLC)Poland · Spain · Portugal - Active not recruitingPHASE2
A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma
This study looks at new drug combinations for kidney cancer that has spread or can't be removed. It compares different immune-boosting medicines with a drug called axitinib to see how safe and effective they are.
For: Renal Cell CarcinomaUnited States · Australia · China - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients with Urothelial Carcinoma (MORPHEUS-UC)
This study, called MORPHEUS-UC, is testing new combinations of medicines for bladder cancer. It looks at how well these treatments shrink tumours or make them disappear, and also checks for any side effects. It's an early-stage study involving people with this type of cancer.
For: Urothelial carcinoma (UC)France · Greece · Spain - RecruitingPHASE3
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
This study offers continued treatment to cancer patients already in certain Genentech/Roche studies. It's for those still benefiting from their current treatment and who can't get it elsewhere. The aim is to bridge care for these patients.
For: CancerBelgium · Canada · China - Active not recruitingPHASE2
A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer
This study is testing new immune-based treatments for a type of bladder cancer that has spread. Researchers want to see if combinations of medicines like tobemstomig and tiragolumab are safe and work better than atezolizumab for people who can't have standard chemotherapy.
For: Urothelial CancerUnited States · Australia · Brazil - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A PHASE IB/II, OPEN-LABEL, MULTICENTER, RANDOMIZED PLATFORM STUDY EVALUATING THE EFFICACY AND SAFETY OF NEOADJUVANT IMMUNOTHERAPY COMBINATIONS IN PATIENTS WITH SURGICALLY RESECTABLE HEPATOCEULLULAR CARCINOMA (MORPHEUS-NEO HCC)
This study is looking into new combinations of medicines for people with a type of liver cancer that can be removed with surgery. It aims to see how well these new treatments work before surgery and if they are safe.
For: Hepatocellular Carcinoma (Morpheus-Neo HCC)Austria · Spain · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Randomized, Blinded, Placebo-Controlled Study of Tiragolumab, an Anti- TIGIT Antibody, in Combination with Atezolizumab in Chemotherapy-Naive Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study looks at a new drug, tiragolumab, combined with an existing cancer drug, atezolizumab (Tecentriq), for people with a type of lung cancer called non-small cell lung cancer that hasn't been treated with chemotherapy yet. It aims to see how well this combination works.
For: Non-small cell lung cancer (NSCLC)Spain · France - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase II/III, Randomized, Double-Blind, Placebo-Controlled Study of Tiragolumab in combination with Atezolizumab plus Pemetrexed and Carboplatin/Cisplatin versus Pembrolizumab plus Pemetrexed and Carboplatin/Cisplatin in Patients with previously Untreated Advanced Non-Squamous Non-Small-Cell Lung Cancer
This study looks at new drug combinations for advanced non-small cell lung cancer. It compares two treatments, one with a new drug called tiragolumab, to see which works best at shrinking tumours, stopping cancer growth, and helping people live longer and have a better quality of life.
For: Non-squamous non-small cell lung cancer (NSCLC)Spain · France · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Randomized, Double-Blind Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Patients with Recurrent/Metastatic PD-L1-Positive Squamous Cell Carcinoma of the Head and Neck
This study looks at new treatments for a type of head and neck cancer. It compares two drug combinations to see if they help shrink tumors and improve how long people live, while also checking for side effects.
For: Squamous cell carcinoma of the head and neck (SCCHN)Greece · France · Poland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blinded, Placebo-Controlled Study of Tiragolumab, an Anti-Tigit Antibody, in Combination with Atezolizumab Compared with Placebo in Combination with Atezolizumab in Patients With Previously Untreated Locally Advanced Unresectable or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer
This study is for people with a certain type of advanced lung cancer that hasn't been treated before. It tests a new drug, tiragolumab, combined with an existing drug, atezolizumab, to see if this combination works better than atezolizumab alone. The aim is to find ways to help people live longer and with better quality of life.
For: Non-small cell lung cancer (NSCLC)Germany · Hungary · Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab Plus Carboplatin and Etoposide with or Without Tiragolumab (Anti-Tigit Antibody) in Patients with Untreated Extensive-Stage Small Cell Lung Cancer
This study is looking into new ways to treat a serious type of lung cancer called small cell lung cancer. It combines standard chemotherapy with a new drug, tiragolumab, and an existing cancer drug, Tecentriq, to see if this mix works better than current treatments.
For: Small cell lung cancer (SCLC)Greece · Italy · Poland - RecruitingPHASE1
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
This study looks at new treatments for bowel cancer that has spread. We want to see if these targeted medicines or immunotherapy are safe and work well for people whose cancer has specific genetic features, which we call biomarkers.
For: Metastatic Colorectal CancerUnited States · Australia · Canada